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Chapter 27
Pharmacology of the Thyroid Gland
8
Pharmacology
Professional
05/19/2012

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Term
Levothyroxine
Definition
L-isomer of T4
Tx: Hypothyroidism and Myexdema coma
AE: Acute myocardial infarction
Term
Liothyronine
Definition
T3
Tx: Myexdema coma and Hypothyroidism
AE: Acute myocardial infarction
Term
Perchlorate
Thyocyanate
Pertechnetate
Definition
Anions with the approximate atomic radius of iodide that compete for Iodide binding
Tx: Hyperthyroidism
Term
131 Iodine
Definition
Radiation treament for Hyperthyroidism
May worsen opthalmopathy in Grave's disease
DO NOT USE IN PREGNANCY
Term
Propylthiouracil
Methimazole
Definition
Thioamines
Compete with thyroglobulin for oxidized iodide
Causes a decrease in organification and coupling of MIT and BIT
Term
Propylthiouracil
Methimazole
Definition
Inhibits thyroid peroxidase as well as peripheral T4 to T3 conversion
Tx: Hyperthyroidism (Storm?)
Term
Propylthiouracil
Methimazole
Definition
AE: Hypoprothrombinemia
CI: PREGNANCY AND BREAST FEEDING (bottom drug)
Term
Ipodate
Definition
5'-deiodinase, inhibiting peripheral T4 to T3 conversion
NO LONGER AVAILABLE
AE: Urticaria, serum sickness, hyperthyroid symptoms
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