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Chapter 26
Pharmocology of the Hypothalamus and Pituitary Gland
30
Pharmacology
Professional
05/19/2012

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Term
Tesamorelin
Definition
Used to help determine the etiology of GH abnormalities
Synthetic GHRH
Term
Somatropin
Definition
Used in high schools to bulk up
Term
Somatropin
Definition
Daily subcutaneous or intramuscular injections
Used for GH deficiency or panhypopituitarism
Recombinant GH
Term
Somatropin (2)
Definition
Used in Prader-Willi Syndrome, Turner's Syndrome, chronic kidney disease, and short stature
Term
Mecasermin
Definition
Recombinant IGF-1
Term
Mecasermin
Definition
Laron dwarfism (GH insensitivity)
Term
Octreotide
Definition
Synthetic, long lasting, Somatostatin
Tx: Acromegaly and Cushings, Esophageal varices and paraneoplastic tumors
Term
Bromocriptine
Cabergoline
Definition
Dopamine analogs
Adjunctive treatment of Acromegaly
Term
Pegvisomat
Definition
GH analog with higher affinity, but without additional binding domain. This prevents receptor dimerization.
Tx: ACROMEGALY
Term
Pegvisomat (AE)
Definition
High cost
Increased liver panel
Term
Bromocriptine
Definition
Synthetic dopamine receptor agonist
TX: Lactinomas
Used in pregnancy
Term
Cabergoline
Definition
Dopamine receptor agonists
Tx: Prolactinomas (low doses) and Parkinsons disease (high doses)
Weekly or bi-weekly administration
Not used in pregnancy
Term
Cabergoline (AE)
Definition
Valvular heart disease
Term
Thyrotropin
Definition
Synthetic TSH
Tx: Used to maximize uptake of radioactive Iodine
Term
Cosyntropin
Definition
Synthetic ACTH
Tx: Used to determine primary or secondary adrenal dysfunction
Term
CRH
Definition
Used to diagnose a pituitary tumor or ectopic tumor for Cushing Syndrome following use of Cosyntropin
Term
Metyrapone
Ketoconazole
Mitotane
Definition
Used to block adrenal steroidal genesis; Especially due to tumors
Term
Mifepristone
Definition
Antagonizes peripheral cortisol receptors
Term
Inhibin
Definition
Produced in the gonads and blocks/decreases levels of FSH but not LH
Term
Activin
Definition
Causes increased production of FSH
Term
Leuprolide
Definition
GnRH agonist
Used in high, constant doses it decreases gonadotropin release
Daily and monthly injections available
Can have a pump installed
Term
Leuprolide (Tx)
Definition
Androgen-dependent prostate cancer
Precocious puberty dependent prostate cancer
Uterine Fibroids
Endometriosis
Term
Urofollitropin
Definition
Purified FSH isolated from the urine of women
Tx: Stimulate ovulation and male hypogonadotropic hypogonadism
Causes ovarian hyperstimulation sundrome
Term
Follitropin
Definition
Synthetic FSH
Tx: Stimulate ovulation and male hypogonadotropic hypogonadism
Causes ovarian hyperstimulation sundrome
Term
Cetrorelix
Definition
GnRH antagonists
Suppress premature surges in LH
Assisted reproduction
Palliation of metastatic prostate cancer
Term
Conivaptan
Definition
Vasopression receptor antagonists (V1 + V2)
Tx: SIADH and hypovolemic and euvolemic hyponatremia
Term
Tolvaptan
Definition
Vasopression receptor antagonists (V2)
Tx: SIADH and heart failure
Term
Demeclocycline
Lithium
Definition
Antibiotic and mineral
Used as secondary for SIADH
Term
Desmopressin
Definition
ADH analogue
Stimulation of V2 receptors
Concentrates urine and decreases thirst
Tx: Diabetes insipidis
Term
Amiloride
Hypochlorothiazide
Definition
Diuretics
Tx: Nephrogenic diabetes insipidis
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