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Chapter 24
Parathyroid
13
Pathology
Professional
05/16/2012

Additional Pathology Flashcards

 


 

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Term
Primary Hyperplasia
Definition
Classically all 4 glands are involved
Frequent asymmetry
Chief cell hyperplasia "water -clear hyperplasia"
Stromal fat is inconspicuous
Term
Parathyroid carcinoma
Definition
Dense, fibrous capsule enclosing the mass
Nearly impossible to diagnose from adenoma without cytologic examination
"Brown tumors"
Term
Hyperthyroidism S/S
Bone
Definition
Osteoporosis
Osteitis fibrosa cystica
Term
Hyperthyroidism S/S
Kidneys
Definition
Renal stones
Polyuria
Secondary polydipsia
Term
Hyperthyroidism S/S
GI
Definition
Constipation
Nausea
Peptic ulcers
Pacreatitis and gall stones
Term
Hyperthyroidism S/S
CNS
Definition
Lethargy
Depression
Seizures
Term
Hyperthyroidism S/S
Cardiac
Definition
Aortic or mitral valve calcification
Term
Secondary hyperparathyroidism
Morphology
Definition
Parathyroid glands are HYPERPLASTIC
Increased numbers of chief cells
Term
Calciphylaxis
Definition
Vascular calcification, resulting in significant ischemic damage to skin and other organs
Term
Familial isolated hypoparathyroidism
Definition
Dominant:
Mutation in PTH precursor protein

Recessive:
Loss-of-function in GCM2, essential for parathyroid development
Term
Chovstek Sign
Definition
Tapping on the facial nerve causes muscle of the eye, mouth, or nose to contract
Term
Trousseau sign
Definition
Carpal spasms produced when circulation to the hand is occluded (blood pressure cuff)
Term
Hypoparathyroidism
Definition
Prolongation of the QT interval and conduction defects
Trousseau and Chovstek signs
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