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Chapter 23
Wiring the Brain
27
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Undergraduate 4
11/30/2010

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Term
subplate
Definition
a layer of cortical neurons lying below the cortical plate early in development; when the cortical plate has differentiated into the six layers of the neocortex, the subplate disappears
Term
radial glial cell
Definition
a glial cell in the emryonic brain extending a process from the ventricular zone to the surface of the brain; immature neurons and glia migrate along this process
Term
neuroblast
Definition
an immature neuron before cell differentiation
Term
cortical plate
Definition
a cell layer of the immature cerebral cortex containing undifferentiated neurons
Term
growth cone
Definition
the specialized tip of a growing neurite
Term
extracellular matrix
Definition
the network of fibrous proteins deposited in the space between cells
Term
fasciculation
Definition
a process in which axons growing together stick to one another
Term
cell-adhesion molecule (CAM)
Definition
a molecule on the cell surface that causes cells to adhere to one another
Term
chemoattractant
Definition
a diffusible molecule that acts over a distance to attract growing axons
Term
netrin
Definition
an axonal guidance module; a protein secreted by cells in specific locations in the developing CNS that can act as either an axonal attractant or a repellent, depending on the type of netrin receptor expressed on the growing axon
Term
chemorepellent
Definition
a diffusible molecule that acts over a distance to repel growing axons
Term
chemoaffinity hypothesis
Definition
the hypothesis that chemical markers on growing axons are matched with complementary chemical markers on their targets
Term
ephrin
Definition
a protein secreted by neurons in many parts of the developing nervous system that helps establish topographic axonal connections
Term
trophic factor
Definition
Term
nerve growth factor (NGF)
Definition
Term
neurotrophin
Definition
Term
apoptosis
Definition
Term
Hebb synapse
Definition
Term
Hebbian modification
Definition
Term
monocular deprivation
Definition
Term
critical period
Definition
Term
ocular dominance shift
Definition
Term
binocular competition
Definition
Term
strabismus
Definition
Term
long-term potentiation (LTP)
Definition
Term
long-term depression (LTD)
Definition
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