Term
Anticholinergic Drugs
What do they do?
What types of receptors can Anticholinergic Drugs act on? |
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Definition
-Block action of acetylcholine on parasympathetic nervous system
-Can act on cholinergic muscarinic or nicotinic receptors |
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Term
Anticholinergic Drugs:
Muscarinic Receptors
where are they found? |
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Definition
| found in brain, secretory glands, heart and smooth muscle |
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Term
Anticholinergic Drugs:
NICOTINIC RECEPTORS
where are they found?
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Definition
| found in autonomic ganglia and skeletal muscles |
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Term
Anticholinergic Drugs
Mechanism of Action/Effects |
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Definition
B/c cholinergic muscarinic receptors are found throughout the body anticholinergic drugs have wide range of effects:
CNS stimulation followed by depressions
Decreased CV response to parasympathetic stimulation
Bronchodilation & decreased respiratory secretions
Antispasmodic effects in GI tract
Mydriasis and cycloplegia of eye
Decreased secretions from salivary glands & sweat glands
Relaxation of uterus,bladder,smooth muscle in gallbladder & bile ducts |
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Term
Anticholinergic Drugs:
INDICATIONS FOR USE |
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Definition
GI & GU disorders
Preoperative
Ophthalmology
Respiratory Disorders
Cardiac Disorders
Parkinson's Disease
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Term
Anticholinergic Drugs:
Individual Drugs:Belladona Alkaloids & Derivatives
ATROPINE |
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Definition
PROTOTYPE for this drug
Drug of choice to treat symptomatic sinus bradycardia, must be moderate to large dose to promote stimulant affect (can cross Blood/Brain barrier), small doses may cause decrease in HR |
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Term
Anticholinergic Drugs:
Individual Drugs:Belladona Alkaloids & Derivatives
HYOSCYAMINE (ANASPAZ) |
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Definition
| Used to treat GI and GU disorders than are characterized by spasms (bladder, stomach,intestinal spasms), increased secretion, and increased motility |
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Term
Anticholinergic Drugs:
Individual Drugs:Belladona Alkaloids & Derivatives
SCOPOLAMINE |
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Definition
Depresses CNS: Causes amnesia, drowsiness, euphoria, relaxation, and sleep
Scopolamine patch (cotton mouth, motion sickness) |
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Term
Urinary Antispasmodics (slows you down from urinating)
OXYBUTYNIN (DITROPAN, DITROPAN XL) |
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Definition
^ bladder capacity, decrease frequency of voiding
ALSO used to treat bladder spasms |
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Term
Urinary Antispasmodics (slows you down from urinating)
TOLTERODINE (DETROL, DETROL LA) |
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Definition
| Inhibits bladder contraction, decrease detrusor muscle pressure and delays urge to void |
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Term
Antisecretory/Antispasmodic
GLYCOPYRROLATE (ROBINUL) |
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Definition
| Antisecretory/Antispasmodic: used to help dry oral/tracheal secretions |
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