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Differentiation of reproductive and CNS in fetus Stimulation of growth and development Coordination of the male and female reproductive system Maintenance of internal environment Adaptation to emergency demands of body |
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Operate within feedback systems Affect only target cells with appropriate receptors The liver inactivates hormones, rendering the hormones more water soluble for renal excretion |
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first messengers) bind to receptors on the target cell membrane, triggering second messengers to affect the cell’s activities |
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bind to receptors within the target cell nucleus and influence cell activity by acting on DNA |
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accelerates water reabsorption from urine in the kidney tubules into the blood, thereby decreasing urine secretion. Controls plasma osmolality |
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stimulates the pregnant uterus to contract; may initiate labor; milk ejection in lactating wome |
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stimulates growth of the thyroid gland; also stimulates it to secrete thyroid hormone |
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stimulates growth of the adrenal cortex and stimulates it to secrete glucocorticoids (mainly cortisol) |
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initiates growth of ovarian follicles each month in the ovary and stimulates one or more follicles to develop to the stage of maturity and ovulation; FSH also stimulates estrogen secretion by developing follicles; stimulates sperm production in the male |
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acts with FSH to stimulate estrogen secretion and follicle growth to maturity; causes ovulation; causes luteinization of the ruptured follicle and stimulates progesterone secretion by corpus luteum; causes interstitial cells in the testes to secrete testosterone in the male |
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stimulates growth by accelerating protein anabolism; also accelerates fat catabolism and slows glucose catabolism; by slowing glucose catabolism, tends to increase blood glucose to higher than normal level (hyperglycemia) |
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stimulates breast development during pregnancy and secretion of milk after the delivery of the baby |
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Prolactin, or lactogenic hormone |
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accelerate catabolism (increase the body’s metabolic rate) |
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decreases the blood calcium concentration by inhibiting breakdown of bone, which would release calcium into the blood |
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Thyroid and Parathyroid Glands |
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Affect growth and maturation of tissues, cell metabolism, heat production, and oxygen consumption
90% T4 and 10% T3
Bound to thyroxine-binding globulin, thyroxine-binding prealbumin, or albumin |
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increases blood calcium concentration by increasing the breakdown of bone with the release of calcium into the blood |
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parathyroid hormone (PTH) |
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increases the blood glucose level by accelerating liver glycogenolysis (conversion of glycogen to glucose) |
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decreases the blood glucose by accelerating the movement of glucose out of the blood into cells, which increases glucose metabolism by cells |
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Insulin synthesized from Secretion promoted by |
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Definition
Proinsulin Secretion is promoted by increased blood gucose level |
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Synthesis of proteins, lipids, and nucleic acids |
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Peptide hormone co-secreted with insulin |
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Glucagon secretion promoted by Glucagon stimulates |
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decreased blood glucose levels glycogenolysis, gluconeogenesis, and lipolysis |
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Possible involvement in regulating alpha- and beta-cell secretions |
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80% of an adrenal gland’s total weight Zona glomerulosa Zona fasciculata Zona reticularis |
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Innervated by the sympathetic and parasympathetic nervous systems |
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Names of hormones (corticoids) |
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Glucocorticoids (GCs) Mineralocorticoids (MCs) Sex hormones |
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chiefly cortisol (hydrocortisone) |
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small amounts of male hormones (androgens) secreted by adrenal cortex of both sexes |
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increase blood sodium and decrease body potassium concentrations by accelerating kidney tubule reabsorption of sodium and excretion of potassium |
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Three cell layers (zones) - Secretion |
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Outer layer, secretes mineralocorticoids Middle layer, secretes glucocorticoids Inner layer, secretes sex hormones |
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Direct effects on carbohydrate metabolism Anti-inflammatory and growth-suppressing effects Influence awareness and sleep habits Most potent naturally occurring glucocorticoid is cortisol |
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Adrenal cortex stimuated by |
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adrenocorticotropic hormone (ACTH) |
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plays an important role in the development and function of the body’s immune system |
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chorionic PLACENTA gonadotropins, estrogens, and progesterone |
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maintain the corpus luteum during pregnancy |
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Tests of Endocrine Function |
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Radioimmunoassay (RIA) Enzyme-linked immunosorbent assay (ELISA) Bioassay |
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Pituitary gland Adrenal glands Thyroid gland and parathyroid glands Pancreas Gonads Pineal gland Thymus Local hormones |
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Hormone Release Controlled by |
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Negative feedback mechanism |
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Blood tests Check serum hormone levels Radioimmunoassay Immunochemical methods Urine tests Stimulation or suppression tests Scans, ultrasounds, magnetic resonance imaging (MRI) Biopsy |
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basic problem is inadequate insulin effects in receptor tissues Deficit of insulin secretion Production of insulin antagonists |
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Autoimmune destruction of beta cells in pancreas Insulin replacement required Acute onset in children and adolescents Not linked to obesity Genetic factors may play a role. |
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Non–insulin-dependent Oral hypoglycemic medications may be used. Caused by decreased production of insulin and/or increased resistance by body cells to insulin Onset is slow and insidious and usually in 50+ age Associated with obesity Component of metabolic syndrome Increasing incidence in teens and young adults |
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Blood glucose levels rise |
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Diabetes Diagnostic Tests |
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Fasting blood glucose level Glucose tolerance test Glycosylated hemoglobin test |
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reduces blood glucose as skeletal muscle uses glucose. |
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Increase insulin secretion Reduce blood glucose levels |
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