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-present at birth -acts against all microbes in the same way -No specific recognition |
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(Immunity) is the ability to ward off diseases caused by microbes and their products |
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lack of resistance or immunity |
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Physical Defenses (1st line) |
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1.Intact skin 2.Lacrimal apparatus 3. Mucous Membranes and Cilia 4. Saliva 5. Urine 6. Defecation and Vomiting |
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Chemical Factors (1st line) |
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Sebum-protective acidic film over skin Lysozyme-antimicrobial in tears, perspiration, saliva, and tissue fluid Gastric Juice- destroy bacteria and most toxins in stomach |
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-antagonize and compete with microbes |
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1.Phagocytosis 2.Inflammation 3.Fever 4.Antimicrobial Substances |
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certain white blood cells are stimulated by chemical signals to ingest microbes or particles |
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1. Neutrophils 2.Eosinophils 3.Monocytes 4.Histiocytes |
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-active during initial infection -mobile (leave blood and enter infected tissue) -60-70% of leukocytes |
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-some are phagocytic -produce toxic proteins against parasites |
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mature into macrophages that roam tissue |
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fixed in certain organs -protect the lungs, liver, bronchial tubes, and spleen |
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redness, pain, heat and swelling -confines and destroys microbes then repairs the tissue by.... 1.Vasodialtion 2. Enhances phagocytosis 3. Tissue repair |
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(caused by histamine, kinins, and prostaglandins) -damaged cells release chemical signals that increase the permeability of blood vessels |
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-repair of stromal (supporting and parenchymal (functioning tissues) -forms scar |
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speed up body reactions that aid repair |
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(cytokine) signals the hypothalamus to reset body temp -stimulates T-cells -Intensifies Interferon (2nd line causes fever) |
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1.Interferon (IFNs) 2.Complement System |
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is an antiviral protein released lymphocytes (macrophages) to inhibit viral replication and protect nearby cells against viral infection
(Antimicrobial Substance) |
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-serum proteins activated in a cascade -protective outcome 1.Opsoniztion 2. Inflammation 3. Cytolysis
(Antimicrobial Substances) |
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-attract phagocytes by serum proteins coating bacterial cells for detection
(Complement System) |
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Serum proteins attack and lyse microbial membrane
(complement System) |
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