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Chapter 16
DNA
24
Biology
12th Grade
08/13/2008

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Term
transformation
Definition
the conversion of a normal animal cell to a cancerous cell; a change in genotype and phenotype due to assimilation of external DNA by a cell
Term
bacteriophage
Definition
a virus that infects bacteria, also called a phage
Term
double helix
Definition
the form of native DNA, referring to its two adjacent polynucleotide strands wound into a spiral shape
Term
semiconservative model
Definition
type of DNA replication in which the replicated double helix consists of one old strand, derived from the old molecule, and one newly made strand
Term
replication fork
Definition
a Y-shaped region on a replicating DNA molecule where new strands are growing
Term
helicase
Definition
an enzyme that untwists the double helix of DNA at the replication fork
Term
topoisomerase
Definition
isomerase enzymes that act on the topology of DNA
Term
primer
Definition
an already existing RNA chain bound to template DNA to which DNA nucleotides are added during DNA synthesis
Term
primase
Definition
an enzyme that joins RNA nucleotides to make the primer
Term
DNA polymerase
Definition
an enzyme that catalyzes the elongation of new DNA at a replication fork by the addition of nucleotides to the existing chain
Term
leading strand
Definition
the new continuous complementary DNA strand synthesized along the template strand in the mandatory 5' --> 3' direction
Term
lagging strand
Definition
a discontinuously synthesized DNA strand that elongates in a direction away from the replication fork
Term
sense strand (coding strand)
Definition
the DNA strand with the same sequence as the transcribed mRNA and containing the linear array of codons which interact with anticodons of the tRNA during translation to give the primary sequence of a protein
Term
nonsense strand (non-coding strand)
Definition
the strand that is not translated into mRNA
Term
Okazaki fragments
Definition
DNA sequences, 100 to 200 nucleotides long, synthesized on the lagging strand of DNA in DNA replication, form a continuous strand
Term
DNA ligase
Definition
a linking enzyme essential for DNA replication; catalyzes the covalent bonding of the 3' end of a new DNA fragment to the 5' end of a growing chain
Term
mismatch repair
Definition
the cellular process that uses special enyzmes to fix incorrectly paired nucleotides
Term
nuclease
Definition
a team of enzymes that hydrolyze DNA and RNA into the component nucleotides
Term
nucleotide excision repair
Definition
the process of removing and then correctly replacing a damaged segment of DNA using the undamaged strand as a guide
Term
telomeres
Definition
the protective structures at each end of eukaryotic chromosomes. Specifically, the tandemly repetitive DNA at the end of the chromosomes DNA molecule
Term
telomerase
Definition
an enzyme that catalyzes the lengthening of telomeres. The enzyme includes a molecule of RNA that serves as a template for a new telomere segment
Term
nucleoid
Definition
a dense region of DNA in a prokaryotic cell
Term
nucleosome
Definition
the basic, beadlike unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound around a protein core composed of two copies of each four types of histones
Term
chromatin
Definition
the complex of DNA and proteins that makes up a eukaryotic chromosome
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