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Chapter 16
micro chapter 16
58
Microbiology
Undergraduate 1
04/03/2011

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Term
immunity
Definition
the ability to ward off disease through body defenses
Term
susceptibility
Definition
lack of immunity
Term
innate immunity
Definition
all body defenses that protect the body against any kind of pathogen
Term
adaptive immunity
Definition
defenses (antobodies) against specific microrganisms
Term
first line of defense
Definition
physical barrier and the nonspecific chemicals of the skin and mucous membranes as well as normal microbiota
Term
keratin
Definition
waterproof protein
Term
ciliary escalator
Definition
moves mucous up and out
Term
sebum
Definition
contains unsaturated fatty acids which inhibit the growth of pathogenic bacteria
Term
fungistatic
Definition
inhibits growth of fungi
Term
lysozyme
Definition
found in tears, saliva, nasal secretions, and perspiration
Term
gastric juice pH
Definition
the high acidity (1.2-3.0) prevents microbial growth in the stomach
Term
skin pH
Definition
3-5
Term
vaginal secretion pH
Definition
3-5
Term
plasma
Definition
fluid component in the blood
Term
formed elements
Definition
the cells and cell fragments in the blood
Term
granulocytes
Definition
neutrophils, basophils, eosinophils
Term
neutrophils
Definition
phagocytic and they travel to the site of infection. 60-70%
Term
basophils
Definition
produce histamine, inflammation and allergic response. .5-1%
Term
eosinophils
Definition
toxic to parasites, some phagocytic activity. 2-4%
Term
agranulocytes
Definition
monocytes, dendritic cells, lymphocytes.
Term
monocytes
Definition
mature into macrophages, fixed in lung, liver and bronchi, wander in tissues. 3-8%
Term
dendritic cells
Definition
phagocytic, initiate adaptive immune response
Term
lymphocytes
Definition
induce T cells, B cells and NK cells, involved in specific immunity. 20-25%
Term
T cells
Definition
cell mediated immunity
Term
B cells
Definition
produce antibodies
Term
platelets
Definition
blood clotting
Term
chemotaxis
Definition
process by which phagocytes are attracted to microorganisms
Term
TLRs
Definition
Toll Like Receptors on a phagocyte adhere to the microbial cells
Term
opsonization
Definition
coating the microbe with serum proteins
Term
PAMPs
Definition
Pathogen Associated Molecular Pattern that is recognized by the TLRs on the pathogen
Term
phagolysosome
Definition
cell fusion involved in phagocytosis
Term
antigen processing
Definition
proteins delivered to the surface and displayed and remaining debris is eliminated through exocytosis
Term
inhibit adherence
Definition
M protein, capsules- so compliment proteins cant bind
Term
leukocidins
Definition
kill phagocytes (part of evasion of phagocytosis)
Term
membrane attack complexes
Definition
lyse phagocytes
Term
TNF
Definition
Tumor Necrosis Factor stimulates the production of acute phase proteins
Term
acute phase proteins
Definition
complement, cytokine and kinins
Term
vasodilation
Definition
caused by the release of histamine, kinins, prostoglandins and leukotrienes.
Term
margination
Definition
ability of phagocytes to stick to the lining of blood vessels
Term
diapedesis/emigration
Definition
ability of phagocytes to squeeze through blood vessels
Term
IL-1
Definition
Interleukin-1, released when phagocytes engulf endotoxins. causes fever
Term
protoglandins
Definition
released by the hypothalamus to reset the body to a higher temperature. causes fever
Term
fever
Definition
chill indicates a rising body temperature; crisis (sweating) indicates a falling body temperature (when IL-1 is eliminated)
Term
advantages to fever
Definition
increases transferrins, increases IL-1 activity and produces interferons
Term
disadvantages to fever
Definition
tachycardia, acidosis, dehaydration, 44-66 C is fatal
Term
complement system
Definition
group of serum proteins that activate one another to destroy invading microorganisms
Term
C5b, C6, C7, C8, and C9
Definition
mostly C9, make a pore in the cell membrane to allow cell lysis
Term
C3a and C5a
Definition
bind to mast cells to release histamine
Term
C5a
Definition
attracts phagocytes
Term
C3b
Definition
coats pathogens
Term
classical pathway
Definition
microbe has antibodies attach and these tag the microbe, C1 binds to the stem of the antibodies and then the cascade of activation takes place
Term
capsules
Definition
precent complement activation
Term
surface lipid-carbohydrate complexes
Definition
prevent membrane attack complex formation
Term
interferons
Definition
antiviral proteins produced in response to viral infection
Term
IFN alpha and beta
Definition
induce uninfected cells to produce AVPs that prevent viral replication. Interferons released are produced by virus infected cells to protect neighboring cells by being released, going into the neighboring cell, and inducing the production of AVPs
Term
gamma interferon
Definition
activated neutrophils and macrophages to kill bacteria
Term
transferrins
Definition
iron binding proteins- transport and store iron and deprive most pathogens of available iron
Term
antimicrobial peptides
Definition
AMPs- lyse bacterial cells
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