Term
|
Definition
Metastasize widely and early
Glandular differentiation or mucin producing (worse type)
Most common in women and non-smokers
PERIPHERAL LOCATION |
|
|
Term
| Lung Adenocarcinoma mutations |
|
Definition
KRAS
Amplification of EGFR (Asians, women, non-smokers) |
|
|
Term
| Bronchioalveolar carcinoma |
|
Definition
MULTIPLE TUMOR THAT CAN COALESCE IN THE PERIPHERY
Lepidic growth (grow along pre-existing structures |
|
|
Term
| Nonmucinous bronchioalveolar carcinoma |
|
Definition
| Columnar, peg-shaped, or cuboidal cells |
|
|
Term
|
Definition
Tall columnar cells with cytoplasmic and intra-alveolar mucin
Spread aerogenously, forming satellite tumors |
|
|
Term
|
Definition
Men; MOST CLOSELY RELATED TO SMOKING
Keritinized or intercellular bridges
SQUAMOUS PEARLS |
|
|
Term
| Squamous cell carcinoma mutations |
|
Definition
p53 mutations
Loss of RB1
p16/INK4 is inactivated
High incidence of HER2/NEU expression |
|
|
Term
|
Definition
Scant cytoplasm, ill defined cell borders, absent nuclei
SALT AND PEPPER PATTERN
Neuroendocrine tumor with ectopic secretion
BOTH CENTRAL AND PERIPHERAL
MOST AGGRESSIVE |
|
|
Term
| Small cell carcinoma genetics |
|
Definition
p53 and RB1 mutations
High levels of Bcl2, w/ low BAX |
|
|
Term
|
Definition
Undifferentiated malignant epithelial tumor
Large nuclei, prominent nucleoli, moderate cyotplasm |
|
|
Term
| Squamous cell carcinoma (Secretion products) |
|
Definition
Parathyroid hormone-related peptide (etc.)
Hypercalcemia |
|
|
Term
| Small cell carcinoma (secretion) |
|
Definition
|
|
Term
| Neuroendocrine proliferations |
|
Definition
Carcinoids
Tumorlets
Small-cell carcinoma |
|
|
Term
|
Definition
| Small, inconsequential, hyperplastic, nest of neuroendocrine cells seen in scarring or chronic inflammation |
|
|
Term
|
Definition
Typical- no p53 or Bcl2 or BAX abnormalities
Atypical- Has those mutations; more likely to spread to lymph nodes on resection |
|
|
Term
|
Definition
Finger like or spherical masses
<3-4cm
Most main stem bronchi
COLLAR BUTTON LESION |
|
|
Term
|
Definition
| Intermittent attacks of diarrhea, flushing, and cyanosis |
|
|
Term
|
Definition
Peripheral
Solitary and well-circumscribed |
|
|
Term
|
Definition
| "CANNONBALL LESIONS" are scattered through all lobes: more in the periphery |
|
|
Term
|
Definition
Mainly restricted to the surface of the lung
NOT ASSOCIATED WITH MESOTHELIOMA
Whorls of reticulin and collagen fibers |
|
|
Term
|
Definition
STRONGLY TIRED TO ASBESTOS, WITHOUT INCREASED RISK AMONG ASBESTOS AND SMOKING
Spreads to the Hilar lymph nodes, then the liver |
|
|
Term
| Malignant mesothelioma (Genetics) |
|
Definition
Deletions of chromosomes 1p, 3p, 6q, 9p, or 22q
p16 mutations
SV40 DNA has been found |
|
|
Term
|
Definition
Diffuse, wide spreading lesion
Extensive pleural effusion and direct invasion of thoracic structures
Grayish-pink tissue surrounding the lungs
NUMEROUS, LONG, AND SLENDER MICROVILLI |
|
|
Term
| Lung adenocarcinoma (Morph) |
|
Definition
|
|
