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CHAPTER 15 - INTRO 2 MICROBIO
microbial mechanisms of pathogenicity
30
Biology
Undergraduate 2
06/22/2008

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Term
The ability to cause disease
Definition
Pathogenicity
Term
The extent of pathogenicty
Definition
Virulence
Term
What are portals of entry for pathogens?
Definition

Mucous Membranes

Skin

Panteral routes

Term
ID50
Definition
Infectious dose for 50% of the test population
Term
LD50
Definition
Lethal dose (of a toxin) for 50% of the test population
Term
The ID50 of Bacillus Anthracis (Anthrax)
Definition
  • Skin - 10 - 50 endospores
  • Inhalation - 10,000-20,000 endospores
  • Ingestion - 250,000-1,000,000 endospores
Term
What are some ways that pathogens bind to receptors on host cell?
Definition
  • Gylocalyx:
  • Capsules
  • Fimbriae
  • M protein
  • Opa protein
  • Tapered end
Term
Pathogens can release ______ ?
Definition
Enzymes
Term

How can bacterial pathogens damage host cells?

Definition
  • Using the host's nutrients
  • Direct Damage
  • Making Toxins
  • Plasmids and Lysogeny
Term
Substance that contribute to pathogenicity
Definition
Toxin
Term
Toxigenicity
Definition

Ability to produce a toxin

Term
Toxemia
Definition
Toxin in the blood
Term
Taxoid
Definition
Inactivated toxin used in a vaccine
Term
Antioxin
Definition
Antibodies against a specific toxin
Term
Endotoxin
Definition
  • Source: gram -
  • Relation to microbe: Present in LPS of outer membrane
  • Chemistry: Lipid
  • Fever?: yes
  • Neutralized by antitoxin?: No
  • LD50: Relatively large
Term
Exotoxin
Definition
  • Source: mostly gram +
  • Relation to microbe: By products of growing cell
  • Chemistry: protein
  • Fever?: No
  • Neutralized by antitoxin?: Yes
  • LD50: Small
Term
Membrane disrupting toxins
Definition
Exotoxins
Term
What are superantigens?
Definition

Cause an intense immune response due to release of cytokines from host cells.

Term

What does the B component of a exotoxin do to the host cell?

Definition
The B component of the exotoxin allows it to bind to the receptor of the host and let exotoxin inside the cell.
Term
What does the A component of an exotoxin do to the host cell?
Definition
It alters cell function by inhibiting protein synthesis. Then the B component is released from the cell
Term
How does Exotoxins lyse host cell?
Definition
  • Making protein channels in the plasma membrane
  • Disrupting phospholipid bilayer
Term
What kind of symptoms does a superantigen cause?
Definition
  • Vomiting
  • Fever
  • nausea
  • shock
  • death
Term
Properties of fungi
Definition
  • Fungal waste may cause symptoms
  • chronic infections cause allergic response
  • Tichothecene toxins inhibit protein synthesis
  • Proteases
  • Capsule prevents phagocytosis
  • ergot toxin
Term

An example of aflatoxin

Definition
aspergillus
Term
An example of mycotoxin
Definition
Neurotoxin: Phalloidin
Term
Pathogenic Properties of Protozoa
Definition
  • Presence of protozoa
  • Protozoan waste products may cause symptoms
  • Avoid host defenses by Growing in phagocytes and antigenic variation
Term
Pathogenic Properties of Helminths
Definition
  • Use host tissue
  • Presence of parasite interferes with host function
  • Parasite's metabolic waste can cause symptoms
Term
Pathogenic Properties of Algae
Definition
  • Paralytic shellfish poisining (dinoflagellates)
  • Demoic acid intoxication
Term
What are portals of exit for pathogens?
Definition
  • Respiratory tract (coughing & sneezing)
  • Gastrointestinal tract (feces & saliva)
  • Genitourinary tract (urine & vagina secretion)
  • Skin
  • Blood (biting arthropods, needles, syringes)
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