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Chapter 14
Sodium, Potassium, & Water
14
Physiology
Undergraduate 2
04/07/2011

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Term
What are the three routes by which sodium is lost?
Definition
Sweat, feces, and urine.
Term
Which of those three routes is employed to regulated the body's sodium content?
Definition
Urine.
Term
How does the kidney handle sodium ion?
Definition
66% reabsorption in proximal tubule
26% in loop of Henle
0.6% excreted
Term
How does the kidney handle potassium ion?
Definition
80% reabsorption in proximal tube
Some reabsorbed in Loop of Henle
15% excreted
Term
How does the kidney handle water?
Definition
65% is reabsorbed in proximal tubule
10% in loop of Henle
0.6% is excreted
Term
How does the kidney handle glucose?
Definition
All is reabsorbed in proximal tubule.
Term
Renin
Definition
An enzyme secreted by the juxtaglomerular cells of the juxtaglomerular apparatus in the kidneys. Also turns angiotensinogen into Angiotensin I.
Term
What are the three major controls on its secretion?
Definition
1. Sympathetic nervous system 2. Decreased intra-renal blood pressure 3. Decreased Sodium/chloride concentrations in distal tubules.
Term
How does the autonomic nervous system influence renin secretion from the kidney?
Definition
Sympathetic via beta-one receptor
Term
What are the two hormones controlling the body's sodium levels?
Definition
Aldosterone and ANP/ANH
Term
How can the body control water loss without also controlling sodium loss?
Definition
ADH opens aquaporins allow water through but not sodium via the countercurrent multiplier.
Term
What are the major consequences of hypokalemia?
Definition
Decreased extracellular potassium content
Term
What are the major consequences of hyperkalemia?
Definition
Increased extracellular potassium content.
Term
What is the mechanism by which the body regulates its potassium levels?
Definition
Coritcal collecting ducts can secrete potassium when there is a high potassium diet: Plasma potassium concentration increases and this drives the enhanced basolateral uptake via the Sodium/Potassium ATPase pumps. ALDOSTERONE.
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