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Chapter 13
Drugs Affecting the Autonomic Nervous System
24
Pharmacology
Undergraduate 2
03/16/2013

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Term
Cholinergic-blocking agents CBA
atropine (Atropair)
Definition
inhibits the parasympathetic nervous system by competing with acetylcholine for binding muscarinic receptors.
Term
Cholinergic-blocking agents CBA
atropine (Atropair)
adverse effects
Definition
tachycardia
CNS stimulation
urinary retention in men with prostrate disorders
dry mouth, dry eyes, decreased sweat, and photophobia
Term
Cholinergicagents/parasympathomimetics bethanechol (Urecholine}
Definition
activate the parasympathetic nervous system either directly by binding to cholinergic receptors or indirectly by inhibiting the action of AchE, which prevents the destruction of endogenous Ach so it remains on the cholinergic receptors longer and prolongs its action.
Term
Cholinergic agents/parasympathomimetics
bethanechol (Urecholine)
adverse effects
Definition
profuse salivation,
increased muscle tone,
urinary frequency, bronchoconstriction,
bradycardia
Term
cholinergic agents/parasympathomimetics
bethanechol (Urecholine) used for treatment of:
Definition
glaucoma, urinary retention, myasthenia gravis, and Alzheimer’s disease. (old people stuff)
Term
Cholinergic-blocking agents CBA
atropine (Atropair) used for treatment of:
Definition
Used in the treatment of :
- peptic ulcers and irritable bowel syndrome
- eye exams, to cause mydriasis or cytoplegia
- bradycardia
- asthma.
Term
Adrenergic–blocking agents ABA
prazosin (Minipress)
Definition
inhibits the sympathetic nervous system and produces many of the same rest and digest symptoms of the parasympathomimetics.
Term
Adrenergic-blocking agents ABA
prazosin (Minipress)used for treatment of:
Definition
hypertension, heart failure, dysrhythmias, angina, benign prostatic hypertrophy, and narrow-angle glaucoma.
Term
Adrenergic-blocking agents ABA
prazosin (Minipress)
adverse effects
Definition
dizziness, drowsiness, dry mouth, headache, palpitations, loss of energy and strength
Term
Adrenergic agents (sympathomimetics)- phenylephrine (Neo-Synephrine)
Definition
stimulates the sympathetic nervous system either by:
- directly, by binding to and activating adrenergic receptors, or
- indirectly, by causing the release of norepinephrine from the presynaptic neuron or
- by inhibiting the reuptake or destruction of norepinephrine.
Term
Adrenergic agents Alpha 1 receptors
treatment of
Definition
treatment of nasal congestion or hypotension; causes dilation of pupils during ophthalmic examinations
Term
Adrenergic agents Alpha 2 receptors
treatment of
Definition
hypertension
Term
Beta 1 receptors treatment of
Definition
cardiac arrest, heart failure, and shock
Term
Beta 2 receptors treatment of
Definition
asthma and premature labor contractions
Term
Adrenergic agents or sympathomimetics STIMULATE:
Definition
sympathetic nervous system
Term
Adrenergic antagonists or sympatholytics INHIBIT:
Definition
sympathetic nervous system
Term
Cholinergic or parasympathomimetics STIMULATE:
Definition
parasympathetic nervous system
Term
Cholingergic-blocking agents, anticholinergics, parasympatholytics, or muscarine blockers INHIBIT:
Definition
parasympathetic nervous system
Term
Activation of alpha 1-adrenergic receptors
Definition
located in all sympathetic target organs except the heart, cause constriction of blood vessels and dilation of the pupils.
Term
Activation of alpha 2-adrenergic receptors
Definition
located at presynaptic adrenergic neuron terminals, inhibits the release of norepinephrine
Term
Activation of beta 1-adrenergic receptors
Definition
located in the heart and kidneys, increase the heart rate and the force of contraction of the heart and the release of renin from the kidneys
Term
Activation of beta 2-adrenergic receptors
Definition
located in all sympathetic target organs except the heart, inhibits smooth muscle
Term
Activation of nicotinic receptors
Definition
located in cell bodies of sympathetic and parasympathetic postganglionic neurons, stimulates smooth muscle and secretion of glands
Term
Activation of muscarinic receptors
Definition
located in parasympathetic target organs except the heart, stimulates smooth muscle and secretion from glands
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