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Chapter 13
Viruses, Viroids, and Prions
39
Microbiology
Undergraduate 2
03/06/2012

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Term
general virus characteristics
Definition
inert 'non-living' outside living host cells, when entering a host cell began replicating and are 'alive'
Term
host range
Definition
the spectrum of host cells the virus can infect
Term
bacteriophages
Definition
viruses that infect bacteria
Term
virion
Definition
complete, fully developed, infectious viral particle; nucleic acid + protein coat; different viruses distinguished by different coats
Term
Viruses can be ___________.
Definition
helical, polyhedral, enveloped, or complex
Term
viral taxonomy
Definition
No specific epithet
Term
viral species
Definition
group of viruses sharing the same genetic information and ecological niche
Term
CPE
Definition
Cytopathic effect: when virus infection disrupts the normal linear growth of cells
Term
Virus primary cell line
Definition
derived from tissue slices; only a few generations
Term
virus diploid cell lines
Definition
developed from embryos; lasts few generations
Term
Virus continuous cell lines
Definition
derived from transformed/cancerous cells; can be maintained indefinitely
Term
multiplication of viruses
Definition
one-step growth curve
Term
bacteriophages
Definition
how virus enters cell may differ but all use either lytic or lysogenic cycle. (viral reproduction)
Term
Lytic Cycle
Definition
1. Attachment
2. Penetration - phage lysosome breaks down cell wall and injects nucleic acids
3. Biosynthesis - uses cell machinery to make viral components but NOT yet put together 'eclipse period' *infective visions not present*
4. Maturation - viral components assembled
5. Release - cell lysis and viruses released
Term
Lysogenic Cycle
Definition
does not cause death/lysis of host cell *CAN PROCEED TO LYTIC cycle or incorporate their genetic information into host cell genetic information to start a lysogenic cycle
1. Attachment
2. Penetration - linear phage DNA forms circle inside bacteria
3A. circle can multiply and be transcribed
4A. produces new phages and bacteria lysis
OR
3B. circle recombines with bacterial DNA (prophage: viral DNA inserted into bacterial DNA) * majority of the prophage genes are not expressed
4B. every time bacteria replicates it replicates the prophage
5. a rare spontaneous event (like UV light) 'pops out' the prophage and the lytic cycle begins
Term
Specialized transduction
Definition
the transfer of genes between bacteria through viruses
Term
True or False: Lysogenic bacteria cells CANNOT be infected by the same virus twice.
Definition
True.
Term
Phage conversion
Definition
lysogenic bacteria can exhibit new properties after the prophage insertion
Term
Animal viruses DON'T have tails for cell attachment, but can enter cell by fusing with membrane via viral envelope or enter eukaryotic cells by pinocytosis, DNA viruses attack the nucleus, RNA viruses stay in the cytoplasm, lysogenic viral infections can cause cancer
Definition
Term
Virus Types
Definition
DNA Viruses and RNA Viruses
Term
DNA Viruses: Adenoviruses
Definition
cause common cold
Term
DNA Viruses: Poxviridae
Definition
causes skin lesions
Term
DNA Viruses: Herpesviridae
Definition
cold sores, chicken pox
Term
RNA Viruses
Definition
ssRNA viruses can have in their capsize + sense strand (mRNA) or - (antisense) strand (template) to produce + strand
Term
RNA Viruses: Picomaviradae
Definition
+ strand
Term
RNA Viruses: Togoviradae
Definition
+ strand
Term
RNA Viruses: Rhabdoviridae
Definition
- strand
Term
RNA Viruses: Reoviridae
Definition
dsRNA
Term
RNA Viruses: Retroviridae
Definition
uses reverse transcriptase, HIV/cancer-causing
Term
Provirus
Definition
viral genetic information inserted into Eukaryotic DNA
Term
Oncogenes
Definition
a part of the genome that if changed by certain chemicals, high energy, or viruses can cause cancer
Term
Oncogenic viruses
Definition
viruses capable of causing cancer
Term
Sarcoma and Adenocarcinoma cancers caused by _______
Definition
viruses
Term
Cancer cells are _________________ and often contain TSTA -tumor specific transplantation antigens on their surface or T antigens in their nucleus.
Definition
transformed cells
Term
Latent Infection
Definition
virus can remain in equilibrium with host and not cause infection for years
Term
Persistent/Chronic Viral Infection
Definition
occurs gradually over a long period; typically fatal
Term
Prions
Definition
Proteinaceous infectious particles, multiple out of control the form masses taking up space in the brain, covert healthy proteins into prions by touch
Term
viroids
Definition
short pieces of naked RNA
Term
Some plant diseases caused by _________.
Definition
viroids
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