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Chapter 13/14 Viruses
CLSC 2429
47
Biology
Undergraduate 2
10/24/2008

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Term
Virus
Definition
-obligatory intercellular parasites
-genomes composed of DNA or RNA
-contains a protein coat - CAPSID
Term
Virion
Definition
-extracellular state of a virus
-complete fully developed virus particle capable of infecting a host
Term
Capsid
Definition
Protein which coats the genome
Term
Nucleocapsid
Definition
Capsid + Genome

Comples of Capsid Protein with Viral Nucleic Acid
Term
Nuclear Material of a Virus
Definition
Can be DNA or RNA
Term
Envelope
Definition
-Obtained by Budding through a cellular membrane

-contains a virally coded protein
Term
Classification of Capsid
Definition
1. Symmetry - Icosahedralm Helical or Complex

2. Enveloped or Non-enveloped

3. Number of Capsomers
Term
Bacteriophages
Definition
-Infect Bacteria

-Suspension of bacteria in liquid media
Term
Animal Viruses
Definition
-Infect Eukaryotes

-Infection of living animals

-Inoculation of an embryonated egg
Term
How do viruses multiply?
Definition
1. Attachment or adsorption
2.Penetration (and uncoating)
3. Synthesis of viral proteins and nucelic acids
4. Maturation (Assembly of new virions)
5. Release
Term
Parvoviridae
Definition
Human parvovirus B19 - fifth disease
Term
Human parvovirus B19
Definition
Fifth Disease
Term
HSV1, HSV2
Definition
Coldsores
Term
HHV3
Definition
Chicken Pox
Term
HHV4
Definition
mononucleosis
Term
HHV5, HHV8
Definition
Kaposi's Sarcoma Virus
Cancer
Term
Adenoviridae
Definition
acute respiratory disease
Term
Papovaviridae
Definition
Papilomavirus - warts

Polyomavirus - tumors, Vacuolating agent SV40
Term
Papilomavirus
Definition
Warts
Term
Polyomavirus
Definition
Tumors
Term
Poxviridae
Definition
Variola virus (small pox, cowpox), viral transcriptase transcribes viral DNA, assembly in cytoplasm
Term
Adenovirus
Definition
Gastrointestinal and Respiratory Tract Infections
Term
Hepatitis B Virus
Definition
Liver inflammation and liver carcinoma
Term
Herpes Simplex Virus
Definition
Herpes
Term
Cytomegalovirus
Definition
Congenital neurologic infections
Term
Epstein Barr virus
Definition
infectious mononucleosis

Burkitt's Lymphoma
Term
Papilloma Virus
Definition
Genital Warts

Cervical Cancer
Term
Variola Virus
Definition
Small Pox
Term
Picornaviridae
Definition
ss(+)RNA

Enterovirus

Hepatitis A Virus
Term
Togaviridae
Definition
ss(+)RNA

(Encephalitis)

Rubiviruses (Rubella)
Term
Flaviviridae
Definition
ss(+)RNA

Flavivirus

Hepatitis C Virus
Term
Rhabdoviridae
Definition
ss(-)RNA

Lyssavirus (Rabies)

Vesiculovirus
Term
Filoviridae
Definition
ss(-)RNA

Ebola

Marburg (Hemorrhagic Fever)
Term
Paramyxoviridae
Definition
ss(-)RNA

Parainfluenza

Mumps
Term
Orthomyxoviridae
Definition
ss(-)RNA

Influenza Virus A, B, C, segmented genome
Term
Reoviridae
Definition
dsRNA

In respiratory and Enteric System
Term
Genus Lentivirus
Definition
HIV-1, HIV-2

Causes AIDS
Term
Hepatits A Virus
Definition
Anorexia

Liver inflammation
Term
Rabies Virus
Definition
CNS Infection
Term
Oncogenic Viruses
Definition
infection by certain viruses leads to transformation - process leading to uncontrolled growth
Term
Prions
Definition
Proteinacious infectious particles
Term
Diseases Caused by Prions
Definition
Scrapie

Kuru

Bovine Spongiform Encelopathy
Term
Antiviral Agents
Definition
1. Acyclovir
2. Amantadine
3. Ganciclovir
4. Ribavirin
Term
Acyclovirin
Definition
Antiviral Agent

Inhibits DNA Synthesis (Herpes Viruses)
Term
Amantadine
Definition
Antiviral Agent

Inhibits Virus Penetration

(influenza A)
Term
Ganciclovir
Definition
Antiviral agents

Inhibits DNA Synthesis

Herpes Viruses
Term
Ribavirin
Definition
Antiviral agents

Inhibits DNA, RNA and protein synthesis

Used to treat infant Respiratory Syncytial Virus (RSV) Infections
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