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Chapter 12 - Muscle Physiology
Chapter 12 - Muscle Physiology
23
Physiology
Undergraduate 2
07/14/2011

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Term
What are the characteristics of skeletal muscle tissue?
Definition
-attached to skeleton (fucking duh)
- striated
- voluntary
- contracts rapidly
- tires easily
- extremely adaptable
- can exert force ranging from a fraction of an ounce to over 70 lbs. (unlimited power for Chuck Norris)
- each muscle is an organ made of muscle tissue, blood vessels, nerve fibers, and connective tissue
- muscle fibers extend the entire length of a muscle
Term
What are the characteristics of smooth muscle?
Definition
- in walls of hollow organs (stomach, urinary bladder, respiratory)
- forces food/other substances through internal body channels
- not striated
- involuntary
- sarcoplasmic reticulum is less developed
- NO sarcomeres
- NO transverse tubules
- calcium is sequester in the ECF, which allows for a rapid influx when channels are opened
- can divide (hyperplasia)
Term
What are the characteristics of cardiac muscle?
Definition
- found in the walls of the heart (again, duh)
- striated
- involuntary
- contractions maintained by Sinoatrial (SA) node - "pacemaker"
- neural controls allow heart to rspond to changes in bodily needs (para)sympathetic
- thin filaments have troponin and tropomyosin
- cross bridge activity initiated like skeletal muscle
- calcium enters cell from ECF which leads to SR release of calcium
- cells connected via gap junctions
Term
What are the primary functions of skeletal muscle?
Definition
- moves the skeleton
- produces heat
Term
What is the primary function of cardiac muscle?
Definition
- pumps blood (Do you really need a flashcard for this question, dumbass?)
Term
What are the primary functions for smooth muscle?
Definition
- propels blood, food, and urine through the body
- mixes food in the stomach
Term
What are the four functional characteristics of muscle tissue?
Definition
- excitability (be able to receive/respond to internal/external stimuli)
- contractility (shorten forcibly)
- extensibility (stretch or extend)
- elasticity (recoil; resume original resting length)
Term
What's a butfor?
Definition
It's for pooping, silly.
Term
What is the functional unit of muscle?
Definition
sarcomere
Term
What are the different bands and zones of a sarcomere?
Definition
- A band (dark) - myosin (thick) filaments with parts of actin (thin)
- H zone - middle of the A band; actin does not reach
- M line - vertical center of A band
- I band (liht) - part of actin that does not project into A band
Term
Which protein makes up the thick filaments?
Definition
myosin
Term
Which protein makes up the thin filaments?
Definition
actin
Term
What are the three binding sites of troponin?
Definition
- tropomyosin
- actin
- calcium ion (Ca2+)
Term
To what does the phrase "power stroke" refer?
Definition
The phrase "power stroke" refers to when myosin and actin contact to "pull the trigger." Inorganic phosphate is released during the power stroke.
Term
After the action potential travels along the sarcolemma (plasma membrane of muscle cells), where else will the AP travel?
Definition
transerve tubules
Term
Which ion is released from the sarcoplasmic reticulum during excitation contraction coupling?
Definition
calcium (Ca2+)
Term
What is the role of calcium ions in the contraction of skeletal muscle?
Definition
Calcium in the cytosol binds with troponin, thereby exposing myosin-binding sites). Without calcium, troponin and tropomyosin resume their blocking role.
Term
What energizes the cross bridge cycle?
Definition
ATP is hydrolyzed into ADP and inorganic phosphate at ATPase site; the energy from this reaction places the myosin cross bridges into a cocked position.
Term
What is the end result after a cross bridge cycle?
Definition
- The addition of a new ATP to myosin cross bridges detaches them from actin.
- Cross bridges return to their original shape for a repeat of the cycle.
Term
In order for skeletal muscle to relax, what ion must be removed from the ICF?
Definition
calcium
Term
Where must the calcium be pumped to in order for skeletal muscle to relax?
Definition
sarcoplasmic reticulum
Term
Which conditions can lead to fatigue of a muscle?
Definition
- ATP production is less than ATP use
- accumulation of lactic acid
- ionic imbalances
Term
What is oxygen debt?
Definition
Oxygen debt is the extra amount of O2 that is needed for the restorative processes
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