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Chapter 11: Ingestion
Chapter 11: Ingestion
47
Physiology
Undergraduate 4
11/14/2011

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Term
Need to know
Definition
5, 29, 33, 36/37, 42
Term
Interstitial fluid
Definition
Fluid that fills the space b/w cells (extracellular)
Term
Intravascular fluid
Definition
Fluid found in blood vessels
Term
Isotonic
Definition
There is equal osmotic pressure to the contents of a cell
-a cell in an isotonic solution neither gains nor loses water
Term
Hypertonic
Definition
A solution that contains enough solute that it will draw water out of a cell placed in it
Term
Hypotonic
Definition
A solution that contains so little solute that a cell placed in it will absorb water
Term
Hypovolemia
Definition
Reduction in the volume of the intravascular fluid
-heart can't pump blood effectively=heart failure
Term
Osmometric thirst
Definition
Cellular dehydration caused by an increase in the osmotic pressure of the interstitial fluid
-drives organism to drink
Term
Osmoreceptors
Definition
Neurons that detect changes in solute concentration
-changes in size causes changes in activity
-in the hypothalamus (SFO and OVLT)- detect increased osmotic pressure
Term
Volumetric thirst
Definition
Caused by hypovolemia
-occurs when volume of the blood plasma decreases
-caused by loss of blood, vomiting, etc.
-results in thirst for water and a "salt appetite"
Term
Volumetric thirst is caused by 2 sets of receptors that are located where?
Definition
-Kidneys (control angiotension)
-Heart and large blood vessels (atrial baroreceptors)
Term
Angiotensin
Definition
A hormone that constricts blood vessels and causes retention of sodium and water (salt appetite)
Term
Renin
Definition
Hormone secreted by kidneys
-converts angiotensinogen into angiotensin
Term
Atrial baroreceptors
Definition
Stretch receptors in the atria of the heart
-more blood = more stretched
Term
What is stored in short term-storage and where?
Definition
Carbohydrates
-liver and muscles
Term
What is stored in long-term storage and where?
Definition
Fats
-fat cells
Term
Insulin
Definition
Hormone in pancreas that lets glucose and amino acids into the cell
-converts glucose into glycogen
Term
Glycogen
Definition
Short-term storage of nutrients
-stored in liver and muscle
Term
Glucagon
Definition
Hormone that converts glygogen back into glucose
Term
Triglyceride
Definition
The form of fat storage in adipose cells
-1 molecule of glycerol + 3 fatty acids
Term
Glycerol
Definition
Made when breaking down triglycerides
-liver converts it into glucose
Term
Fatty acid
Definition
Made when triglycerides are broken down
-Metabolized by most cells of the body except for the brain
Term
Fasting phase
Definition
The phase of metabolism when nutrients are not available from the digestive system
-glucose, amino acids, and fatty acids are derived during this phase
Term
Absorptive phase
Definition
The phase of metabolism when nutrients are absorbed from the digestive system
-glucose and amino acids are the main source of energy for cells during this phase
-excess nutrients are stored in adipose tissue in the form of triglycerides
Term
Glucoprivation
Definition
A fall in the level of glucose available to cells
-can be caused by hypoglycemia or injection of insulin
Term
Lipoprivation
Definition
A fall in the level of fatty acids available to cells
-caused by drugs that inhibit fatty acid metabolism
Term
Where are the 2 sets of detectors located for monitoring level of metabolism?
Definition
-Liver
-Brain
Term
Hepatic portal vein
Definition
The vein that transports blood from the digestive system to the liver
Term
What gastric factor is involved in ending a meal?
Definition
Stomach
-contains receptors that detect the presence of nutrients (not just distention)
Term
What 2 intestinal factors are involved in ending a meal?
Definition
-Duodenum
-Peptide YY
Term
Duodenum
Definition
First part of the small intestine, attached to the stomach
-secretes CCK: a hormone that provides a satiety signal to the brain
Term
Peptide YY (PYY)
Definition
A peptide released by the gastrointestinal system after a meal in an amount proportional to the size of a meal
Term
What liver factor is involved in ending a meal?
Definition
Receptors that detect nutrients and send signals to your brain
Term
What role does insulin have in the absorption phase of metabolism?
Definition
The brain contains receptors that respond to insulin
-might be a satiety signal (obese mice)
Term
Leptin
Definition
A hormone secreted by adipose tissue
-decreases food intake
-increases metabolic rate
Term
Ob mouse
Definition
A strain of mice whose obesity is caused by a lack of the production of leptin
Term
If you lesion/stimulate the lateral hypothalamus (LH), what would happen?
Definition
Lesion: won't eat
Stimulate: eat
Term
Melanin-concentrating hormone (MCH)
Definition
NT found in the LH that stimulates appetite and reduces metabolic rate
Term
Orexin (hypocretin)
Definition
NT found in the LH that stimulates appetite and reduces metabolic rate
Term
Neuropeptide Y (4)
Definition
NT found in the arcuate nucleus that:
-stimulates feeding
-stimulates insulin secretion
-decreases breakdown of triglycerides
-decreases body temperature
Term
Infusions of NPY into the hypothalamus do what?
Definition
Cause ravenous eating
Term
Injections of NPY receptor blockers into the hypothalamus do what?
Definition
Suppresses eating caused by food deprivation
Term
Agouti-related peptide (AGRP)
Definition
A peptide that is a strong and long-lasting stimulant of eating
Term
Ghrelin
Definition
A peptide that increases eating
-in stomach and brain
Term
Arcuate nucleus
Definition
Contains NPY-secreting neurons involved in feeding and control of metabolism
-controls the anterior pituitary gland
-located in the hypothalamus
Term
Paraventricular nucleus (PVN)
Definition
Contains neurons involved in the control of the:
-autonomic nervous system
-posterior pituitary gland

-located in the hypothalamus
Term
Ventromedial hypothalamus
Definition
Plays a role in controlling the cessation of eating
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