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Ch. 16
Molecular Basis of Inheritance
16
Biology
Undergraduate 1
01/29/2009

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Term
Helicase
Definition
unwinds parental double helix at replication forks
Term
Single-strand binding protein
Definition
binds to and stabilizes single-stranded DNA until it can be used as a template
Term
Topoisomerase
Definition
Relieves "overwinding" strain ahead of replication forks by breaking, swiveling, and rejoining DNA srands
Term
Primase
Definition
Synthesizes an RNA primer at 5' end of leading strand and of each Okazaki fragment of lagging strand
Term
DNA polymerase III
Definition
Using parental DNA as a template, synthesizes new DNA strand by covalently adding nucleotides to the 3' end of a pre-existing DNA strand or RNA primer
Term
DNA polymerase I
Definition
Removes RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides
Term
DNA ligase
Definition
Joins 3'end of DNA that replaces primer to rest of leading strand and joins Okazaki fragments of lagging strand
Term
Okazaki Fragment
Definition
segments that allow 5' end to be added to
Term
mismatch repair
Definition
enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors
Term
nuclease
Definition
enzyme that cuts out damaged DNA segment
Term
Nucleotide Excision Repair
Definition
a repair system that removes then correctly replaces a damaged segment of DNA using the undamaged strand as a guide
Term
Telomere
Definition
tandemly repetitive DNA at the end of a eukaryotic chromosome's DNA molecule that protects the organism's genes from being eroded during the successive rounds of replication
Term
nucleoid
Definition
dense region of DNA in a bacterium
Term
Heterochromatin
Definition
interphase chromatin, visible as irregular clumps
Term
Euchromatin
Definition
less compacted, more dispersed chromatin
Term
Bacteriophages
Definition
viruses that infect bacteria
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