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Ch 35 Pharm
Fungal Infections
35
Biochemistry
Graduate
08/29/2012

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Cards

Term
MOA Flucytosine
Definition
Inhibition of thyamide synthase
Term
Flucytosine TX
Definition
Cryptococcis, Candidas, Chromyelosis
Term
AE Flucytosine
Definition
BM suppression, Hepatic issues, GI
Term
X Flucytosine
Definition
Pregnancy
Term
X Flucytosine
Definition
Pregnancy
Term
Griseofulvin MOA
Definition
inhibits mitotic spindle formation
Term
Griseofulvin TX
Definition
Hair, Skin, Nail infection
Term
Griseofulvin AE
Definition
BM supression, Headaches, Hepatitis
Term
What is Flucytosine combined with to treat aspergillos
Definition
Ampotarian B
Term
Griseofulvin X
Definition
Pregnancy
Term
Griseofulvin effects
Definition
Increase P450 and warfarin metabolism
Term
Terbinofine MOA
Definition
inhibition of squalene epoxidase
Term
Terbinofine Tx
Definition
Tineas, and Onchomycosis (nail infections)
Term
Terbinofine AE
Definition
SJ syndrome, worsen lupus and psoriasis, Hepatotoxic
Term
Naftafine/Butenafine MOA
Definition
inhibit squalene epoxidase
Term
Naftafine/Butenafine Tx
Definition
Topical tinea infections- cream
Term
Azole- MOA
Definition
inhibits 14alpha sterol demthylase blocking ergostol formation
Term
Ketoconazole TX
Definition
Blastomyces, Histoplasma, Candadia
Term
Ketaconazole AE
Definition
GI distress, Hepatic, gyneocomastia, menstral abnormalities
Term
Ketoconazole X
Definition
Do not take with Amphotericin B
Term
Butoconazole, Cotrimazole, Econazole, Miconazole, Oxiconazole, SErtaconasole, Sulconazole TX
Definition
superficial fungal infections of the eye and skin
Term
FV PIT
Definition
Fluconazole Voriconazole Posaconazole Intraconazole Terconazole
Term
Fluconazole TX
Definition
Cryptococcal Menengitis ; Candidas
Term
Intraconazole TX
Definition
Broad Spectrum
Term
Voriconazole TX
Definition
Invasive aspergliosis
Term
Posaconazole
Definition
Prophlactic Asp and Candadisis
Term
Terconazole TX
Definition
Vaginal Candidas
Term
Caspofungin MOA
Definition
inhibits formation of Cell wall B-glucan
Term
Caspofungin TX
Definition
Candidas/Asperglios
Term
Caspofungin AE
Definition
Itching Rash Liver enzyme increases, headache, fever
Term
Amphotericin B MOA
Definition
forms holes in the fungal wall and leaks electrolytes
Term
Amphotericin B TX
Definition
Serious fungal systemic infections
Term
Nystatin MOA
Definition
binds to esterol and forms pores to leak electrolytes
Term
Nystatin TX
Definition
Oral, Vaginal, Diaper Candidas
Term
Amphotericin B AE
Definition
cytokine storm (fever shaking), kidney toxicity, arrythmia, anemia, phlebitis
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