Term
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Definition
increase the contractile force of cardiac myocytes |
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Term
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Definition
intraventricular blood volume |
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Term
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Definition
resistance against left ventricle ejection |
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Term
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Definition
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Term
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Definition
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Term
Ca stimulates this receptor on SR |
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Definition
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Term
Cacliuum binds to which troponin |
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Definition
Troponin C: release inhibitory troponin I |
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Term
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Definition
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Term
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Definition
increased force of contraction due to increased end diastolic volume of the left ventricle |
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Term
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Definition
increased stretch releases more Ca from SR and allows for more actin/myosin binding sites |
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Term
2 types of pumps in cardiac muscle |
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Definition
Na/K ATPase, and NA/Ca Exchanger |
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Term
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Definition
SERCA once phospholamban is phosphorylated |
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Term
Phosphorylates phospholamban |
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Definition
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Term
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Definition
increased heart rate in dose format |
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Term
Positive Lusitropic effect |
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Definition
enhanced rate and extent of disastolic relaxation |
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Term
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Definition
Lusitropic effect is very important to maintain output with increased HR |
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Term
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Definition
dilates vascular smooth muscle, increased gluconeogenesis, glycogenolysis |
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Term
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Definition
increase chronotrophy and inotropy, increased AV node velocity, increased renin secretion |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Vascular smooth muscle contraction GU SM contraction GI SM RELAXATION Heart: increased Rate and Inotrophy |
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Term
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Definition
decrease insulin, block platelet aggreg, decrease NE release, Vascular smooth muscle contraction |
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Term
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Definition
decreased systemic resistance, and afterload |
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Term
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Definition
increased vascular reisistance and afterload |
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Term
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Definition
inhibits Na/K ATPase channel |
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Term
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Definition
increases intracellular Na and leads to decreased calcium efflux and thus SR can pick up more Ca+ |
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Term
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Definition
decreased automaticity of AV node, prologned refractory period of AV node, inhibits sympathetic outflow and increased parasympathetic tone |
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Term
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Definition
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Term
Digoxin can be effected by what ion |
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Definition
Hypokalemia- increases digoxen binding in heart muscle |
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Term
Digoxin can be effected by what ion |
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Definition
Hypokalemia- increases digoxen binding in heart muscle |
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Term
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Definition
Hyperkalemia to promote dephosphorylation of proteins |
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Term
Digoxen plus Beta blockers |
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Definition
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Term
Beta blockers/Ca blockers effects on digoxen |
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Definition
block the inotrophic effects |
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Term
K wasting diuretics (furosemide) + digoxen |
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Definition
decrease plasma potassium and can lead to increased affinity of digoxen with NA/K ATPase channels |
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Term
Life threatening Digoxen overdose |
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Definition
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Term
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Definition
Systolic heart faiure, Supraventricular arrythmias (afib, a flutter, paroxysmal atrial tachy) |
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Term
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Definition
Systolic heart faiure, Supraventricular arrythmias (afib, a flutter, paroxysmal atrial tachy) |
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Term
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Definition
with kidney failure (due to liver metabolism) |
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Term
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Definition
arrhythmias, AV block, PVC, agitation, blurred vision with yellow green halo |
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Term
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Definition
Never with ventricular fib. or tachy |
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Term
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Definition
life threatening digitalis toxicity |
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Term
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Definition
Heart failure, anaphylaxis |
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Term
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Definition
overall cardiostimulatory effect |
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Term
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Definition
vasodilatory effect thru D1 in renal and mesenteric vascular beds |
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Term
Dopamine intermediate infusion |
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Definition
vasodilation via stimulation of B2 receptors and activates b1 receptors increasing rate and strength of contraction |
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Term
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Definition
activates A1 receptor leading to vasoconstriction and increased afterload |
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Term
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Definition
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Term
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Definition
Bradycardia, asthma, wideening of QRS, arrhythmias |
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Term
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Definition
pheochromocytoma, v fib, uncorrected tachy arrhythmias |
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Term
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Definition
decrease metabolism and result in tachycardia and arrhythmia |
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Term
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Definition
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Term
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Definition
modest peripheral vasodilation via b2 receptor |
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Term
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Definition
treates cardiac decompensation due to cardiogenic shock |
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Term
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Definition
less frequent arrhytmias than dopamine |
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Term
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Definition
Bronchospasm, anaphylactic shock, cardiac resuscitation, nasal congestion |
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Term
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Definition
open angle glaucoma, prolongs local anethetic use |
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Term
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Definition
non selective a1, a2, b1, b2 agonist |
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Term
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Definition
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Term
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Definition
a1 vasoconstriction and increased afterload |
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Term
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Definition
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Term
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Definition
nonselective b1, a1 and a2 agonist |
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Term
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Definition
used for acute hemodynamic support due to shock in the absence of heart disease |
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Term
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Definition
arrhythmias, cerebral hemorrhage, hypertension, headache, tachycardia, nervousness |
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Term
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Definition
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Term
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Definition
emergency arrhythmias, atropine resistant arr, heart block, broncospasm |
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Term
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Definition
do not use with angina or digitalis intoxication |
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Term
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Definition
PDE inhibitor leading to increased cAMP and increased Ca intracellularly |
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Term
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Definition
PDE inhibitor leading to increased cAMP and increased Ca intracellularly |
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Term
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Definition
PDE inhibitor leading to increased cAMP and increased Ca intracellularly |
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Term
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Definition
decrease preload and decrease after load |
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Term
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Definition
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Term
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Definition
reversible neutropenia and agranulocytosis |
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Term
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Definition
enhances troponin c to calcium sensitivity and induces periperial vasodilation |
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Term
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Definition
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