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chosen by TH morgan generation time of 2 weeks 180 million bases, and 13,700 genes. |
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matures in 3.5 days. genome is 97 million bases long. 19,000 genes. they are hermaphrodites |
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an organism chosen for study, nemotode, fruity fly etc. |
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this is a vertebrate. genome is 2,600 million base pairs 25,000 genes. about the same as humans generation time of 9 weeks |
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embryos develop outside mother generation 2-4 months. early and fast development by the first 24 hours 1700 Million base pairs long |
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common wall cress arabidopsis thaliana |
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in the mustard family can germinate and produce thousands in 8 weeks. 118 million base pairs long 25,500 genes |
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process in which cells become specialized in structure and function, organized into tissues/organs |
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"creation of form," organized into tissues and organs |
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blastula - sphere of cells surrounding a fluid filled cavity. when this folds inward it is a gt, gastrula. |
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in morphogenesis - cell division and cell wall expansion rather than cell tissue movement in animals. apical meristems develop. |
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they all have the same genes |
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worked with carrot plants, showed that cell differentiation does not necessarily involve irreversible changes in the DNA. |
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structures responsible for plants continual growth and formation of new organs @ the tips of shoots and roots. |
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mature cells can dedifferentiate and then give rise to all the specialied cell types of the mature organism. ability of a single cell to divide and produce all the differentiated cells in an organism, including extraembryonic tissues. |
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remove the nucleus of an unfertilized egg cell or zygote and replace it with the nucleus of a differentiated cell. |
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Robert Briggs, Thomas King and Extended by John Gurdon |
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they transplanted a nucleus from an embryonic or tadpole cell into an enucleated egg of the same species. concluded that: something in the nucleus does change as animals differentiate. nuclear potency |
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relatively unspecialized cell that can both reproduce itself indefinetely and under appropriate conditions differentiate into specialized cells of one or more types. |
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able to give rise to multiple but not all cell types, contrast of totipotent embryonic stem cells |
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cloning to produce embryonic stem cells to treat disease |
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the events that lead to the observable differentiation of a cell the out come of differentiation is marked by the expression of genes for tissue specific proteins. |
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proteins found only in a specific cell type and give the cell its characteristic structure and function |
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is a type of stem cell that exists in muscles. |
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maternal substances in the egg that influence the course of early development |
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signal molecules cause changes in nearby target cells. signal molecules usu change their gene expression and this results in observable cellular changes. |
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development of a spatial organization in which the tissues and organs of an organism are all in their characteristic place. "setting up and animals body" |
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the molecular cues that control pattern formation, provided by cytoplasmic determinants and inductive signals. |
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change from larva to adult fly. |
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this revealed the specific molecules that guide development. he used mutants to investigate fly development. located abnormalities to specific genes. GENES DIRECT THE DEVELOPMENTAL PROCESSES. |
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Nusslein-Volhard and Eric Wieschaus. |
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studied pattern formation during early development. tried to identify all the genes that affect segment formation. |
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mutations with phenotypes causing death at embryonic or laval stage, these never reproduce and cannot be bred for study. |
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a gene that, when mutant in the mother, results in a mutant phenotype in the offspring, regardless of genotype. |
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maternal effect genes are these. control the oreientation (polarity) of the egg and the fly. |
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gradients of substances called morphogens establish an embryos axes and other features of its form |
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a substance governing the pattern of tissue development and, in particular, the positions of the various specialized cell types within a tissue. It spreads from a localized source and forms a concentration gradient across a developing tissue. |
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genes of the embryo whose products direct formation of segments after the embryos major body axes are defined. |
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3 sets of segmentation genes |
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gap genes, pair rule genes and segment polarity genes. |
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the segments set by master regulatory genes, discovered by Edward Lewis |
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nematodes are very useful in research of |
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the entire ancestry of every cell in the body. shows the fate of all the cells in the developing embryos |
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arises from 6 precursor cells on the embryos ventral surface |
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programmed cell death. 2 genes in nemotodes are ced-3 and ced-4 |
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the main proteases of apoptosis, these are activated the by apoptosis pathways and cut up DNA |
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three proteins critical to apoptosis |
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John Sulston and Robert Horvitz |
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studied roles of induction and apoptosis during development of nematodes. advanced understanding of how genes regulate organ growth and process of programmed cell death. |
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carpels (contain egg cells) stamens (contain sperm pollen) petals sepals(leaflike structures outside the petals) |
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organisms with a mixture of genetically different cells |
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genes controlling organ identity, determines the type of structure that will grow from a meristem. analogous to homeotic genes in animals |
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a 180 nucleotide sequence, which specifies a 60 amino acid homeodomain in the protein |
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