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Ch 19 Blood
Lecture
106
Anatomy
Undergraduate 1
02/24/2011

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Term
What is the funtion of the Cardiovascular system
Definition
To transport materials to and from cells.
Term
Materials transported to and from cells are: 5 of them
Definition
-Oxygen and CO2
-Nutrients
-Hormones
-Immune system components
-waste products
Term
What are the main components of the cardiovascular system?
Definition
-A pump
-A conducting system (blood vessels)
-A fluid medium (blood)
Term
What is characterized by fluid of connective tissue and contains cells suspended in a fluid matrix.
Definition
The blood (A fluid medium)
Term
What has a high viscosity and is three times thicker than water?
Definition
Blood
Term
What is slightly alkaline at 7.35 - 7.45
Definition
Blood
Term
Blood volume is ___ % of body weight?
Definition
7
Term
Blood volume in Adult male is...
Definition
5 to 6 liters
Term
Blood volume in adult females is....
Definition
4 to 5 liters
Term
Transport of dissolved substances is a _________ of blood.
Definition
Function
Term
Regulation of ____ and _____ is a funtion of blood.
Definition
pH and ions
Term
Restriction of _____ losses at injury sites is a funtion of blood.
Definition
fluid
Term
Defense against_____ and ______ is a funtion of blood.
Definition
toxins/pathogens
Term
_______________ of body temperature is a function of blood.
Definition
Stabalization
Term
Plasma and formed elements are characteristics of what?
Definition
Whole blood
Term
Plasma is _____% water
Definition
90
Term
Plasma has __________ plasma proteins
Definition
dissolved
Term
glucose, clotting factors, mineral ions, hormones and carbon dioxide are characteristics of what?
Definition
plasma
Term
What are three types of formed elements in whole blood?
Definition
rbc,wbc, and platelets
Term
Erythrocytes are ______.
Definition
rbc
Term
leukocytes are _______.
Definition
wbc
Term
RBC or WBC are part of the immune system?
Definition
WBC
Term
What are cell fragments involved in clotting?
Definition
Platelets
Term
A process of producing formed elements is?
Definition
hemopoiesis
Term
A process of seperating whole blood for clinical analysis
Definition
fractionation
Term
Albumins, Globulins, and fibrinogens are what?
Definition
plasma proteins
Term
Albumins are ____% of plasma proteins?
Definition
60
Term
Globulins are ____% of plasma proteins?
Definition
35
Term
Fibrinogens are _____% of plasma proteins?
Definition
4
Term
Transport substances such as fatty acids, thyroid hormones and steroid hormones
Definition
Albumins
Term
Antibodies, also called immunoglobulins
Definition
Globulins
Term
hormone-binding proteins, metalloproteins, apolipoproteins(lipoproteins)and steroid-binding proteins
Definition
Transport globulins
Term
Molecules that form clots and produce long, insoluble strands of fibrin= fibrous protein
Definition
fibrinogen
Term
The red pigment that gives whole blood its color
Definition
hemoglobin
Term
Hemoglobin
Definition
Binds and transports oxygen and carbon dioxide.
Term
What has a high surface to volume ratio?
Definition
RBC
Term
Because of ____ having a high surface to volume ratio they can quickly _______ and release ________.
Definition
RBC/absorb/Oxygen
Term
In RBC, disc form stacks called ______.
Definition
rouleaux
Term
In RBC, what smooths the flow through narrow blood vessels?
Definition
rouleaux
Term
Discs ____ and _____entering small capallaries= 7.8 um
Definition
bend/flex
Term
RBC pass through ____ capallaries.
Definition
4 um
Term
How long do RBC live?
Definition
120 days
Term
What lacks a nuclei, mitochondria and ribosomes?
Definition
rbc
Term
What has no repair and anaerobic metabolism because the lack of nuclei, mitochondria, and ribosomes
Definition
rbc
Term
What breaks hemoglobin into its components?
Definition
Phagocytes
Term
In the breakdown of hemoglobin....
Globular protein to _________
Definition
amino acids
Term
In the breakdown of hemoglobin......
Heme (pigment in RBC) TO _______
Definition
biliverdin
Term
After phagocytes break hemoglobin to it components:
Globular proteins to________
Heme to ______
and _______.
Definition
amino acids
biliverdin
iron
Term
Hemoglobin breakdown products in urine due to excess hemolysis in blood stream =
Definition
hemoglobinuria
Term
Whole red blood cells in urine due to kidney or tissue damage =
Definition
hematuria
Term
Occurs only in RED BONE MARROW in adults
Definition
erythropoiesis
Term
Stem cells in red bone marrow divide to produce
Definition
myeloid stem cells
Term
_______ become RBC, some WBC.
Definition
myeloid stem cells
Term
Lymphoid stem cells become
Definition
lymphocytes
Term
Amino acids, Iron, Vitamin B12, B6 and Folic acid are required for what?
Definition
building RBC
Term
What is secreted by kidneys when oxygen in peripheral tissues is low (hypoxia)
Due to disease or high altitude.
Definition
Erythropoietin (EPO)
Term
What blood cell does not have hemoglobin?
Definition
WBC
Term
Which blood cell has a neclei and other organelles?
Definition
WBC
Term
Functions of ________
Defend against pathogens
Remove toxins and wastes
Attack abnormal cells
Definition
WBC
Term
Neutrophils are a type of RBC or WBC
Definition
WBC
Term
Eosinophils are a RBC???
Definition
False
Term
What type of WBC has a pale cytoplasm with lysosomal enzymes and bactericides (hydrogen peroxide and superoxide)
Definition
Neutrophils
Term
When you see pus that means that this type of WBC is working
Definition
Neutrophils
Term
What is the first to attack bacteria
Definition
Neutrophils
Term
Phagocytosis is when ______ engulf pathogens
Definition
neutrophils
Term
Neutrophils digest pathogens by ________ and ________.
Definition
degranulation and defensins.
Term
The release of antimicrobial cytotoxic molecutles from secretory vesicles(granules)
Definition
degranulation
Term
Defensins are proteins that
Definition
attack membranes by poking holes in the membrane
Term
The release of prostaglandins and leukotrienes contribute to the ______ response
Definition
Inflammatory
Term
Defensins (proteins) are packaged in primary granules and they fuse with ______
Definition
phagocytic vacuoles
Term
During _________, defensin-rich primary granules (red) fuse with ______ in which they generate ____ concentrations of defensins.
Definition
Phagocytosis/phagocytic vacuoles/high
Term
Which WBC attacks large parasites and excretes toxic compounds?
Definition
Eosinophils
Term
Nitric oxide (NO) and cytotoxic enzymes are toxic enzymes of ________.
Definition
Eosinophils
Term
What destroys the membranes of invaders?
Definition
the toxic compounds NO & Cytotoxic enzymes of Eosinophils
Term
Which WBC accumulate in damaged tissue, release histamines and release heparin?
Definition
Basophils
Term
The release of histamines _____ blood vessels
Definition
dialates
Term
The release of heparin _________.
Definition
prevents blood clotting
Term
What help us bring in more blood to deal with pathogen infection?
Definition
The release of histamin by the basophil
Term
Which WBC enters peripheral tissues and becomes macrophages, engulf large particles and pathogens, secrete substances that attract immune system cells and fibrocytes to injured area?
Definition
monocytes
Term
Which WBC migrates in and out of blood, mostly in connective tissues and lymphatic organs and are part of the body's specific defense system?
Definition
lymphocytes
Term
T cells, B cells, and natural killer cells are classes of what kind of WBC?
Definition
Lymphocytes
Term
Which class of lymphocyte is cell-mediated immunity and attack foreign cells directly?
Definition
T cells
Term
Which class of lymphocyte deals with humoral immunity, differentiate into plasma cells and sythesize antibodies?
Definition
B cells
Term
What class of lymphocyte detects and destroys abnormal tissue cells (cancer)?
Definition
natural killer cells (NK)
Term
(platelets)Cell fragments involved in human clotting system
Circulate for ______ days.
Definition
9-12
Term
Cell fragments (platelets) in human clotting system are removed by the ______.
Definition
spleen
Term
2/3 are reserved for emergencies
Definition
platelets
Term
Three functions of the _______ are
release of important clotting chemicals
temporarily patch damaged vessel walls
actively contract tissue after clot formation
Definition
platelets
Term
Platelet production is called?
Definition
thrombcytopoiesis
Term
What is the cessation of bleeding called?
Definition
hemostasis
Term
how many stages of hemostasis are there?
Definition
3
Term
Vascular stage, platelet plug formation and blood clotting are stages of?
Definition
hemostasis
Term
In the vascular phase ______ muscle in artery ______.
Definition
smooth/constricts
Term
What phase of hemostasis does the platelets stick to parts of damaged blood vessel, become activated and accumulate lare numbers
Definition
platelet plug formation
Term
Serum in blood plasma minus ___________.
Definition
clotting proteins
Term
Series of chemical reactions culminating in formation of fibrin threads
Definition
clotting
Term
What two ions are essential to the clotting process?
Definition
Calcium and K
Term
Extrinsic or intrinsic pathways lead to the formation of prothrombinase (this is a phase of what)
Definition
clotting
Term
Prothrombinase (enzyme) converts prothrombin (made by liver) into thrombin (coagulation protein)this is a phase of what?
Definition
clotting
Term
thrombin converts fibrogen (soluble) to fibrin (insoluble) forming the threads of the clot. What phase of clotting is this?
Definition
third and last
Term
Extrinsic or intrinsic? Tissue factor or thromboplastin leaks into the blood from cells outside blood vessels and iniates formation of prothombinase?
Definition
extrinsic
Term
Extrinsic or intrinsic? Activators are either in direct contact with blood or contained within the blood. Also forms prothrombinase
Definition
intrinsic
Term
Fibrinolyis is
Definition
the slow process of dissolving a clot
Term
Activated by thrombomodulin and is a major physiological anticoagulant
Definition
protein c
Term
Vasodilator;prevents formation of the platelet plug
Definition
prostacyclin
Term
What digests fibrin strands?
Definition
plasmin. produced by plasminogen
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