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Ch 19 A & P II
Anatomy and Physiology II Chapter 19
85
Anatomy
Undergraduate 2
01/30/2010

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Term
Blood's contribution to homeostasis
Definition
Transports oxygen, carbon dioxide, nutrients, hormones to and from body cells.
Term
What does blood regulate/protect
Definition
PH, temperature, protection against disease by production of antibodies and phagocytosis
Term
Hematology
Definition
Branch that studies blood, blood forming tissues, and associated disorders.
Term
Blood and interstitial fluid
Definition
Fluids that obtain oxygen and nutrients, and eliminate carbon dioxide and other wastes
Term
Plasma
Definition
liquid extracellular matrix, dissolves and suspends cells and cell fragments
Term
Interstitial fluid
Definition
Bathes body cells.
Term
Physical characteristics of blood
Definition
PH 7.35-7.45
Temperature 38C (100.4F)
Term
Blood's volume and percentage of body weight
Definition
4-6 liters adults
8% body weight adult
Term
Plasma/formed elements
Definition
55% Plasma
45% Formed elements
Term
Hematocrit
Definition
% of total blood volume occupied by red blood cells
Term
Blood's water/solutes
Definition
91.5% water, 8.5% solutes
Term
Blood's solutes
Definition
Proteins (albumins, globulins, fibrinogen)
nutrients, vitamins, hormones, respiratory gases, electrolytes, and waste products
Term
Formed elements in blood
Definition
Red blood cells, white blood cells, platelets
Term
Hemopoesis
Definition
Formation of blood cells from hemopoietic stem cells in red bone marrow
Term
Myeloid stem cells
Definition
Form RBC's, platelets, granulocytes, monocytes.
Term
Lymphoid stem cells
Definition
Give rise to lymphocytes
Term
Hemopoietic growth factors
Definition
Stimulate differentiation and proliferation of various blood cells.
Term
Describe mature RBC's
Definition
Biconcave discs that lack nuclei and contain hemoglobin.
Term
Function of hemoglobin in red blood cells
Definition
Transport oxygen and some carbon dioxide.
Term
RBC's life span
Definition
120 days
Term
RBC normals
Definition
Male 5.4 million/uL
Female 4.8 million/uL
Term
1uL
Definition
1 microliter=1mm3=10(-6)liter
Term
Aged RBC's
Definition
Phagocytosis by macrophages, hemoglobin is recycled
Term
Erythropoiesis
Definition
Occurs in red bone marrow
Stimulated by hypoxia, which stimulates the release of erythropoietin by kidneys
Term
Reticuloycte Count
Definition
Test that indicates rate of erythropoiesis.
Term
Nucleated WBC's two types
Definition
Granulocytes: neutrophils, eosinophils, basophils
Agranulocytes: lymphocytes and monocytes
Term
Function of WBC's, how it occurs
Definition
Combat inflammation and infection. Neutrophils and macrophages(developed from monocytes) do through phagocytosis
Term
Function of eosinophils
Definition
Combat effects of histamine in allergic reactions
Phagocytize antigen-antibody complexes
Combat parasitic worms
Term
Functions of basophils
Definition
Liberate heparin, histamine, and serotonin allergic reactions that intensify the inflammatory response.
Term
B-lymphocytes response to antigens (foreign substances)
Definition
Differentiate into plasma cells that produce antibodies, they attach to antigens and render them harmless
Term
Antigen-antibody response
Definition
Combats infection and provides immunity.
Term
T-Lymphocytes in antibody-antigen reaction
Definition
destroy foreign invaders directly
Term
NK cells in antibody-antigen response
Definition
Attack infectious microbes and tumor cells
Term
WBC normals
Definition
5,000-10,000 WBCs/uL
Term
Platelets/Thrombocytes
Definition
Disc shaped cell fragments that splinter from megakaryocytes.
Normal: 150,000-400,000 platelets/uL.
Term
Platelet function
Definition
Help stop blood loss from damaged blood vessels by forming platelet plug.
Term
Bone marrow transplants
Definition
Removal of red bone marrow as a source of stem cells from the iliac crest
Term
Cord blood transplant
Definition
Stem cells from placenta are removed from umbilical cord, advantages over bone marrow transplants.
Term
Hemostasis
Definition
Stoppage of bleeding
Term
Hemostasis involves
Definition
Vascular spasm, platelet plug formation, blood clotting (coagulation).
Term
Vascular spasm
Definition
Smooth muscle of BV wall contracts and slows blood loss.
Term
Platelet plug formation
Definition
Aggregation of platelets to stop bleeding.
Term
Network of clot
Definition
Insoluble protein fibers (fibrin) in which formed elements of blood are trapped.
Term
Clotting factors
Definition
Chemicals involved in clotting
Term
3 stages of blood clotting
Definition
1. Formation of prothrombinase
2. Conversion of prothrombin into thrombin
2. Conversion of soluble fibrinogen into insoluble fibrin.
Term
Initiation of clotting
Definition
Interplay of extrinsic and intrinsic pathways of blood clotting.
Term
Normal coagulation
Definition
Vitamin K, followed by retraction/tightening of clot, ultimately fribrinolysis/dissolution of the clot.
Term
Thrombosis
Definition
Clotting in an unbroken blood vessel
Term
Embolus
Definition
A thrombus that moves from its site of origin.
Term
Serum
Definition
Plasma minus clotting proteins
Term
Clot retraction
Definition
Consolidation/tightening of fibrin clot that brings edges of damaged vessel together.
Term
RBC
Definition
Contain hemoglobin and function in gas transport
Term
Platelets
Definition
Cell fragments enclosed by a piece of the cell membrane of megakaryocytes, contain clotting factors
Term
Colony forming units
Definition
Individual forms of progenitor cells; named on the basis of the mature elements in blood they will ultimately produce
Term
Monocytes
Definition
WBC's showing a kidney shaped nucleus; capable of phagocytosis
Term
Wandering macrophages
Definition
Monocytes that roam the tissues and gather at sites of infection and inflammation
Term
Lymphocytes
Definition
Occur as B cells, T cells, and NK cells
Term
Myeloid stem cells
Definition
Give rise to red blood cells, monocytes, neutrophils, eosinophils, basophils, and platelets.
Term
Eosinophils
Definition
Combat the effects of histamine and other mediators of inflammation in allergic reactions; also phagocytize antigen-antibody complexes
Term
Neutrophils
Definition
Respond to tissue destruction by bacteria; release lysozyme, strong oxidants, and defensins
Term
Polymorphs
Definition
Older several differently shaped nuclear lobes
Term
Reticulocytes
Definition
Released from red bone marrow, they develop into mature red blood cells
Term
Lymphoid stem cells
Definition
Give rise to lymphocytes
Term
Progenitor cells
Definition
Cells no longer capable of replenishing themselves; can only give rise to more specific formed elements of blood
Term
Thrombopoietan
Definition
Hormone that stimulates the formation of platelets
Term
Fixed Macrophages
Definition
Monocytes that leave the blood and reside in a particular tissue such as alveolar macrophages in the lungs
Term
Basophils
Definition
Involved in inflammatory and allergic reactions; are involved in hypersensitivity reactions.
Term
Cytokines
Definition
Stimulate white blood cell formation
Term
Pluripotent stem cells
Definition
Cells that give rise to all the formed elements of blood; derived from mesenchyme
Term
Erythropoietin
Definition
Hormone that increases the number of red blood cell precursors
Term
Thromboplastin
Definition
Tissue protein that leaks into the blood from cells outside blood vessels and initiates the formation of prothrombinase
Term
Platelet-derived growth factor
Definition
Platelet hormone that stimulates repair of damaged vessel walls.
Term
Prothrombinase
Definition
Its formation is initiated by either the extrinsic or intrinsic pathways, or both; catalyzes the conversion of prothrombin to thrombin
Term
Aggultinogens
Definition
Glycoproteins and glycolipids on the surfaces of red blood cells that can act as antigens
Term
Fibrin
Definition
Forms the threads of a clot; produced from fibrinogen
Term
Plasmin
Definition
Can dissolve a clot by digesting fibrin threads.
Term
Thrombin
Definition
Serves as catalyst to form fibrin; formed from prothrombin
Term
Hematocrit
Definition
Percentage of total blood volume occupied by red blood cells
Term
Differential WBC count
Definition
The percentage of each type of WBC
Term
CBC
Definition
Measures WBC's, RBC's, platelets per "u" of blood; hematocrit and differential WBC count
Term
Reticulocyte count
Definition
Measures the rate of erythropoiesis
Term

neurotransmitters

Definition

dopamine norepinephrine serotonin

Term

Nerve cell path

Definition

dendrite - cell body - axon - synapse - specific receptor - dendrite

Term

neurotransmitters

Definition

dopamine norepinephrine serotonin

Term

Nerve cell path

Definition

dendrite - cell body - axon - synapse - specific receptor - dendrite

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