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Ch 10
Immuno Chapter 10
22
Immunology
Professional
03/12/2011

Additional Immunology Flashcards

 


 

Cards

Term
Mucosal Surfaces
Definition
contitute a huge area of the body vulnerable to infections. Contains a high level of IgA.
Term
GALT
Definition
gut associated lymphoid tissue, fetal differentiation is independent from other lymphoid tissue.
Term
Lamina Propria
Definition
Underlying connective tissue
Term
Peyer's Patches
Definition
Aggregates of lymphocytes and dendritic cells just under intestinal lumen. Separated from lumen by enterocytes and microfold.
Term
Tonsils/adenoids
Definition
Located at the back of the mouth and guarding entrance to the gut and the airways. They are large aggregates of secondary lymphoid tissue, covered in squamous epithelium, and forma ring known as Waldeyer's ring.
Term
Enterocytes
Definition
secrete digestive enzymes and mucus
Term
M cells
Definition
Take up intact pathogens adn antigen particles. Transfer to the Peyer's patches.
Term
Lymphoid follicles
Definition
Present in large intestine and appendix. Consists mostly of B cells.
Term
Villi
Definition
Fingerlike processes that specialize in the uptake and further breakdown of already degraded food coming from the stomach.
Term
Intraepithelial lymphocyte
Definition
A distinctive type of CD8 T cell that is integrated into the epithelial layer of the small intestine.
Term
Gut-homing lymphocytes
Definition
express integrins that bind to vascular addressins and are guided by a chemokine.
Term
Integrins
Definition
expressed by gut-homing lymphocytes
Term
Addressins
Definition
Bind to integrins in the gut-homing lymphocyte process
Term
Chemokines
Definition
guide the gut-homing lymphocyte process by a chemokine.
Term
Dimeric IgA
Definition
Secreted in mucosal tissue. Non-inflammatory antibody that does not bind complement and has many IgA antibodies to commensal orgnanisms.
Term
IgA2
Definition
Long hinge, some bacteria make proteases that specifically cleave the longer hinge.
Term
IgA1
Definition
Short hinge and protected by a carbohydrate.
Term
IgA deficiency
Definition
Most people do not have ill effects, IgM can substitute for IgA.
Term
Helminth infections
Definition
TH2 response is better than TH1 because IgE helps mast cells and eosinophils to bind to the parasite.
Term
Protective Immunity
Definition
antibodies bind and neutralize the pathogen before it has a chance to infect and spread.
Term
Immunological Memory
Definition
memory T and B cells provide a much faster and potent immune response in a second exposure or infection.
Term
Antigenic sin
Definition
First virus strain limits future response to other strains.
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