Term
a) how are colloids characterized?
b) explain their effect from gravity and surface area
c) what is the size range of colloids? |
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Definition
a) by submicroscopic size
b) no effect from gravity and a very high total particle surface area
c) from 0.001-1um (very small particles to very large molecules |
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Term
a) what is the size range for a micrsphere
b) how is the mcs usually dispersed, and how does it work
c) what are the advatages (doa, target, side effects) |
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Definition
a) 1-100um
b) dispersed in an aqueos medium ad gradually degrades to gradually release incorporated drug
c) longer doa (month) bypasses degredation of oral route, localized to its site of action so get an inc concetration and lower systemic side effects |
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Term
a) what makes up the MCS matrix?
b) how is it degraded?
c) what is the rate determining step |
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Definition
a) water insolube copolymer (poly lactic acid or poly glycolic acid)
b) water hydrolyzes the ester bond
c) hydrolysis |
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Term
a) what is the size range of aerosols?
b) how does it work
c) what are its advantages (onset, degredation, dose)
d) disadvantages |
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Definition
a) 0.5-10 um
b) drug is explelled by liquified or gas propellants under pressure
c) quick onset, avoids degredation in GI, dose can be titrated for individual needs, greater bioavailability
d) drug can be irritating, administration difficulties |
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