Term
T/F
Iontophoresis allows for the andministration of a lower dose than oral and less toxicity |
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Definition
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Term
| In Phonophoresis, the drug is mixed with____ |
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Definition
| coupling agent (gel, cream, ointment) |
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Term
| A fast dissolving tablet should be administed via____ |
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Definition
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Term
| What are some theories to keep drugs in the stomach for a longer time? |
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Definition
| Making expandable or floatable tablets |
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Term
| Enteric coated tablets break up in a _____environment |
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Definition
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Term
| Why do some drugs have colon-specific delivery? |
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Definition
to treat colon-related diseases (IBS, Uclerative Colitis)
To get systemic absorption of proteins and peptides |
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Term
| What are the 4 types of colon specific deliverys systems? |
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Definition
| PRodrugs, pH dependent, time dependent, bacterial eznyme dependent |
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Term
| What is a potential problem with drugs dependent on bacterial enzymes in the colon? |
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Definition
| Colonic flora is dependent on diet, use of abx etc |
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Term
| What effect do extended release drugs have on max concentration, absorption, toxicity, and AUC? |
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Definition
max concentration is decrease
absorption is increased
toxicity is decreased
AUC is greater |
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Term
| How do oral adhesive systems work? |
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Definition
| The mucus has a net (-) charge and the polymers have a (+) charge and are attracted to eachother |
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Term
| Oral adhesive drugs must be effective in____concetrations |
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Definition
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Term
| For vaginal delivery systems the dosage must be _____to administer for long periods of time |
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Definition
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Term
T/F
Vaginal delivery systems can last from 12hrs to one year depending on the drug |
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Definition
TRUE
Progestasert (one yr)
Dinoprostone (12hrs) |
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Term
| Why do we use gels for opthalmics? |
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Definition
| It is a viscosity increasing agent that increases corneal contact time |
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Term
| What equation can be used to determine the drug release of Pilocarpine insert. |
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Definition
Noyes-Whitney equation
dM= DSKΔC
dt h |
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Term
| What is the difference between liposomes and micelles? |
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Definition
Micelles have a hydrophobic interior
Liposomes have a hydrophilic interior |
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Term
| What are the advantages of liposomes for parenteral delivery? |
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Definition
site specific target
useful for both hydrophilic/phobic drugs
protection of other tissues until drug released
size and charge can be altered |
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Term
| What are some disadvantages of liposomes for parenteral delivery? |
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Definition
drug release can be slow
they are destroyed by cells of the RES |
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Term
| How are stealth liposomes better than regular liposomes? |
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Definition
They are Pegulated and not detected by the RES
They have longer circulation times |
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Term
What is PEGylation?
How is the helpful? |
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Definition
attaching PED molecules to proteinss
increases half-life and circulation times |
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|
Term
What are microspheres?
What effect do they have drug release and compliance?
Stability?
Routes of administration?
|
|
Definition
drug coated with polymers
sustained drug release and increase compliance
increase stability
Injection or inhalation |
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Term
T/F (microspheres)
a) they are too large for targeting (subQ)
b) release is zero order
c) way to eliminate toxicty |
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Definition
a) TRUE
b) FALSE rarely 0 order
c) FALSE may be toxic due to dose dumping |
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Term
T/F (implants)
a) pts may have an immune response at the implant surface
b) they have higher variability than controlled release injectables
c) increased efficacy and decreased side effects due to local delivery |
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Definition
a) TRUE
b) FALSE lower variability
c) TRUE |
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Term
| What are the 2 types of implantable devices? |
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Definition
Reservoir (capsule)
Matrix (tablet) |
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Term
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Definition
| any technique that uses living organisms for the production or modification of products |
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Term
Term
a) proteins produced by B lymphocytes in response to antigens
b) ATB from the culture of a single ancestral B cell
c) ATB obtained from the blood of an immunized animal
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|
Definition
a) Antibody
b) monoclonal ATB
c) polyclonal ATB |
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Term
T/F
Recombinant DNA technology can prepare human proteins from nonhuman cells |
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Definition
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Term
TERM
exogenous genetic material transferred into somatic cells to correct gene defects |
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Definition
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Term
| What is used to block synthesis of unwanted proteins such as VEGF in cancer? |
|
Definition
| antisense nucleotide sequence |
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Term
TERM
screening polypeptides that can mimic larger proteins |
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Definition
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