1. Red nucleus - stimulates flexors, inhibits extensors

2. reticular formation (ant and post lobe)-

pons (medial) stimulates extensors; MCP

medulla (lat.) inhibits extensors; ICP

3. Vestib. nuclei- go to FN lobe 

4. cerebral cortex- Ant limb of int. cap.-> pons -> Transverse Pontine Fibers -> ant and post cerebellum

from upper limb proprioceptors (mostly muscle spindles)

pathway: m. spindle; accessory cuneate nucleus (medulla); ICP; cerebellar anterior lobe 

leg proprioceptors (mostly muscle spindle)

pathway: m. spindle; nucleas dorsalis of clarke; ICP; anterior lobe

GTO from lower limb; SCP; anterior limb

GTO from upper limb; SCP and ICP; anterior lobe

• tactile signals (mostly from flexors)
• synapse on ION (medulla) and then go to anterior and posterior lobe via ICP

• wrap around purkinje cell dendrites
• climbing fiber - excites purk cell directly - inhibits deep cerebellar nuclei 
• arise from ION 
• 1 climbing fiber excites 1 purkinje cell dendrite

• arise from everything in the CNS except ION
• mossy - granule cell - transient excitation of granule cell - inhibits deep cerebellar nuclei
• 1 mossy fiber excites many purkinje cells

Feedback:

mossy - granule cell - golgi cell dendrite - golgi cell axon - inhibition of granule cell

feedforward:

mossy fiber - golgi cell - granule cell

Midline (vermal) cerebellar cortex - fastigial nucleus - axial musculature 

Lateral (Paravermal and hemispheres) cerebellar cortex) - interposed and dentate nucleus - distal musculature 

Cerebellum

Red Nucleus

DISTAL MUSCULATURE

dentate and interposed nuclei leave via SCP

SCP synapses on Red Nucleus or VL of thalamus

VL nuclei projects to motor and premotor cortex (this is the major output)

red nucleus gives rise to rubrospinal track or projects to ION (for feedback inhibition)

• axial musculature
• to vestibular nuclei and than vestibulospinal tract
• to reticular formation and than reticulospinal tract

due to disruption of the feedback circuit b/n the cerebellar cortex and the cerebral cortex that governs the movement of distal musculature 

symptoms:

• decompostion of movements (movements broken down into individual components)
• asynergy (loss of coordination)
• dysmetria (finger to nose problems)
• dysdiadochokineasia (rapid alternating movements)
• intention tremor 

• gait ataxia
• falls to the side of the lesion
• lesions of the vestibulocerebllum, fastigial nucleus, vestibular nucleus, reticular formation, or spinal cord

• ipsilateral lesions of the anterior lobe
• disruption of the lateral vestibular nucleus that modulate muscle spindle activity 

lesion of the vermal region of the cerebellar cortex or fastigial nucleus

dies to disruption of the inputs in the MLF from the vestibular nuclei

ipsilateral