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Cellular Pathophysiology
Aiery
68
Pathology
Graduate
08/24/2013

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Term
plasma memebrane
Definition
regulates entrance and exit of molecules
Term
cytoskeleton
Definition
maintains cell shape
Term
microtubules
Definition
protein cylinders that move organelles
Term
microfilaments
Definition
associated with muscles
Term
intermediate filaments
Definition
protein fibers that provide stabliity of shape
Term
actin filaments
Definition
protein fibers that play a role in change of shape
Term
centrioles
Definition
short cylinders of microtubules of unknown functions
Term
centrosome
Definition
microtubule organizing center that contains a pair of centrioles
Term
lysosome
Definition
vesicle that digests macromolecules and cell parts
Term
vesicle
Definition
small membrane-bound sac that stores and transports substances
Term
cytoplasm
Definition
semifluid matrix outside nucleus that contains organelles
Term
nucleus
Definition
command center of the cell
Term
nuclear envelope
Definition
double membrane with nuclear pores that encloses nucleus
Term
chromatin
Definition
diffuse threats containing DNA and protein
Term
nucleolus
Definition
region that produces subunits of ribosomes
Term
endoplasmic reticulum
Definition
protein and lipid metabolism
Term
rough ER
Definition
studded with ribosome s that synthesize proteins
Term
smooth ER
Definition
lacks ribosomes, synthesizes lipid molecules
Term
peroxisome
Definition
vesicle that is involved in fatty acid metobolism
Term
ribosomes
Definition
particles that carry out protein synthesis
Term
mitochondrion
Definition
organelle that carries out cellular respiration (Krebs, aerobic) producing ATP molecules
Term
golgi apparatus
Definition
processes packages and secretes modified proteins
Term
proteasomes
Definition
breakdown proteins
Term
4 Functions of cell membrane
Definition
Separates intra from extra cellular; provides receptor for cell singaling and selective transport; generate and conduct electrical current; regulate cell growth and replication
Term
Function of ATP to cell metabolism
Definition
stores the energy created in cellular respiration, and open and close membrane channels
Term
Aerobic metabolism
Definition
uses oxygen and consists of glycolysis, the citric acid cycle (Krebs, mitochondria) and the electron transport chain yielding a net gain of 36 ATP per each molecule of glucose
Term
Anaerobic metabolism
Definition
Does not use oxygen and consist of glycolysis only yielding a net gain of 2 ATP per each molecule of glucose (in cytoplasm)
Term
Diffusion
Definition
Movement of molecules from area of high concentration to an area of low concentration
Term
Osmosis
Definition
Diffusion of WATER across a membrane toward an area of higher concentration of ions, in order to dilute the substance.
Term
Endocytosis
Definition
Process of a cellular membrane enveloping a substance and brining it into the cell in a vesicle
Term
Exocytosis
Definition
Process of expelling a vesicle out of a cell through the cell membrane
Term
Active transport
Definition
process that requires energy to move a substnace across the cell membrane; usually against a concentration gradient
Term
ion channels
Definition
Allow or block ions from crossing lipid membranes in response to stimuli, leak channels or gated channels( voltage, ligand and mechanically) stimulated
Term
signal transduction
Definition
series of biochemical reactions that allows cells to receive and respond to messages coming in through cell membranes; ligand binds with a membrane-bound receptor forming a ligond-receptor complex, this activates the G protein which activates an enzyme (adenylate cyclase) that is bound to the inner surface of the cell membrane, this removes two phosphates from ATP and circulates it, forming cAMP which actives the protein kinases. the protein kinases bind with an inactivate substrate and activate it which leads to cellular changes.
Term
G protein
Definition
Activates or inactivates an enzyme example (adenylate cyclase) that is bound to the inner surface of the cell membrane, this removes two phosphates from ATP and circulazes it, forming cAMP which activates protein kinases
Term
Membrane potentials
Definition
unequal distribution of positive and negative ions on two sides of a membrane which creates stored electrical energy that can be used to do work at some future time
Term
Epithelial tissue
Definition
Covers the body surface and organs, forms inner lining of body cavities and lines hollow organs, lacks blood vessels, heals rapidly. Basal surface is the basement membrane
Term
Connective tissue
Definition
Most abundant type by weight bone blood cartilage; bind structures and provide support and protection; store fat and produce blood cells
Term
Muscle Tissue
Definition
elongated shape, contractile, skeletal smooth and cardiac
Term
nervous tissue
Definition
brain, spinal cord, and peripheral nerves, neurons and neuroglial cells
Term
extracellular matrix
Definition
fibers and a ground substance whose cosistency varies from fluid to semisolid to solid; it binds supports and provides a medium for substances to transfer between blood and cells within tissues
Term
Cell junctions
Definition
where cells connect
Term
tight junction
Definition
cell membrane fuse; sheet like layers in digestive tract and tiny blood vessels
Term
desmosome
Definition
spot welds, skin cells without them you get blisters
Term
hemidesmosome
Definition
attach cells to basement membrane
Term
gap junctions
Definition
channels linking cytoplaam of adjacent cells allowing small molecules to move between them, heart muscle and digestive tract
Term
glycocalxy
Definition
very important; used for cell to cell recognition and adhesion; made of a long carbohydrate chain attached to a protein molecule/lipid molecule or lectin
Term
ligands
Definition
messenger molecules that initiate physiological changes inside the cell; ex hormones (epinephrine)
Term
main factors contributing to the membrane potential
Definition
Difference in concentration of ions (They will want to move from high to lower concentration); permeability of the membrane (are the channels opened to let certain ions in, can they diffuse across by themselves/ use leak channels?)
Term
The diffusion potential
Definition
describes the voltage generated by ions that diffuse across the cell membrane
Term
equilibrium potential
Definition
one in which there is no net movement across the membrane because the diffusion potential and the electrical forces generated by the movement of the ion are exactly balanced
Term
Examples of lipid soluble things= diffusion
Definition
oxygen, co2, hormone
Term
active primary transport
Definition
need energy because both items are going against their concentration gradient (going from low to high concentration); need a carrier protein with ATP!
Term
Secondary transport
Definition
Carries the transport solute using energy: uses energy from a gradient that was created by a primary active transport system that used ATP; (examples: symport, antiport)
Term
Only muscle and nerve cells have this?
Definition
action potential
Term
pinocytosis
Definition
cells get smaller; when i have a lot of osmotically active items outside of the cell; water rushes out of the cell to dilute the high concentration outside
Term
phagocytossi
Definition
cell gets bigger; when a lot of items/ osomatically active stuff is inside the cell water rushes in to dilute the cell
Term
osmotic pressure
Definition
"SUCKING POWER"; the higher the concration of ions the higher the gradient: sucking the water TOWARD the particles
Term
voltage gated channels open/ respond to
Definition
change in membrane potential; when they hit the action potential the channels open to let ions in!
Term
simple epithelium
Definition
single layer of cells that are all resting on the basement membrane
Term
simple squamous
Definition
function: filtration; found in the lining of blood vessels, lymph nodes and the alveoli of the lung
Term
simple cubodiol
Definition
Found: in ovary and thyroid
Term
Simple columnar
Definition
found: in intestine and gall bladder
Term
Stratified and pseudostratified Function
Definition
to protect the body surface; contain more then one layer of cells
Term
stratified squamous keratinzed epithelium
Definition
epidermis of skin
Term
stratified squamous unkeratinzed epithelium
Definition
Location: mouth and tongue
Term
stratified cuboidal: location
Definition
ducts of sweat glands
Term
pseudostratified cilated columnar location
Definition
trachea and bronchi
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