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Cell Wall
test 4
39
Pharmacology
Graduate
11/05/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Penicillins
Definition
Cell wall inhibitors- B lactams- widely effective, low toxicity
Term
Cephalosporins
Definition
Cell wall inhibitors- B lactams
Term
Imipenem/cilastatin (Primaxin)
Definition
B-Lactam, cell wall inhibitor
Term
Aztreonam (Azactam) IV/IM
Definition
B-lactam, cell wall inhibitors- monobactams. narrow spectrum enterobacteria aerobic gm - rods only
Term
Vancomycin
Definition
cell wall inhibitor- not systemic, punches holes in wall. MRSA sensitive
Term
Bacitracin
Definition
cell wall inhibitor- active against wide variety of gm +. topical only d/t nephrotoxicity potential
Term
Mupirocin (Bactroban)
Definition
cell wall inhibitor-topical; impetigo, eradicate nasal MRSA
Term
B- lactams
Definition
inhibit transpeptidase enzyme, interdere with last step in cell wall synthesis, inactive against mycobacteria, protozoa, fungi, viruses.
Term
imipenem
Definition
cell wall inhibitor- B lactam, Carbapenem
Term
Clavulanic acid
Definition
B Lactamase inhibitors- no significant antibacterial activity
Term
Sulbactam
Definition
B Lactamase inhibitors- no significant antibacterial activity
Term
Tazobactam
Definition
B Lactamase inhibitors- no significant antibacterial activity
Term
1st generation PCN
Definition
Natural penicillins
Term
2nd generation PCN
Definition
Antistaphylococcal PCN
Term
3rd generation PCN
Definition
Extended spectrum PCN
Term
4th generation PCN
Definition
Antipseudomonal PCN
Term
Penicillin G
Definition
Benzylpenicillin- natural PCN. For non-penicllinase producing cocci (+&-), gram + bacilli, spirochetes. Meningococcal infections, syphilis, anaerobes
Term
Penicillin V
Definition
Natural PCN- more acid stable, for oral infections
Term
Antistaphylococcal PCNs
Definition
penicillinase- resistant
Term
Methicillin
Definition
Antistaphylococcal PCNs- for nephritis, rarely used. injected. AE= nephritis
Term
Nafcillin
Definition
Antistaphylococcal PCNs- injected. not for nephritis
Term
Cloxacillin
Definition
Antistaphylococcal PCNs- Oral, chronic infections. Parenteral: for serious staph infections
Term
Diclozacillin
Definition
Antistaphylococcal PCNs- Oral, chronic infections. Parenteral: for serious staph infections
Term
Oxacillin
Definition
Antistaphylococcal PCNs- Oral, chronic infections. Parenteral: for serious staph infections
Term
Ampicillin
Definition
extended spectrum PCN. (PO/IM/IV). DOC for Listeria monocytogenes. AE maculopapular rash
Term
Amoxicillin
Definition
extended spectrum PCN (PO). Dental procedure prophylaxis, completely absorbed
Term
Ticarcillin (IM/IV)
Definition
Antipseudomonal PCN. AE= platelet dysfunction
Term
Piperacillin (IM/IV)
Definition
antipseudomonal PCN, most potent
Term
Carbenicillin
Definition
PCN AE= platelet dysfunction
Term
Cephalosporins
Definition
semisynthetic B-lactam antibiotics
Term
PCN G substitutes that are resistant to staphylococcus B-lactamase
Definition
1st gen cephalosporins
Term
active against PEck
Definition
1st gen Cephalosporins
Term
Cefazolin (Ancef, Kefzol)- IM/IV
Definition
1st gen Cephalopsprin- good for severe & bone infections. used in orthopedic surgery
Term
active against HENPEck
Definition
2nd generation cephalosporins
Term
Cefoxitin (Mefoxin) IM/IV
Definition
2nd gen cephalosporins- active against anaerobic bacteria
Term
Ceftriaxone (Rocephin) IM/IV
Definition
3rd gen cephalosporins- DOC Meningitis
Term
Cefotaxime (Claforan) IM/IV
Definition
3rd gen cephalosprins- DOC meningitis
Term
Cefepime (Maxipime) IV
Definition
4th gen cephalosporins- wide spectrum antibiotic
Term
DOC for treatment of serious infections caused by several gm - bugs
Definition
cephalosporins
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