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Cell Structure & Function
test 1
67
Pathology
Undergraduate 1
01/16/2013

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Cards

Term
Golgi apparatus
Definition

"protein packaging plant"

packages the ribosomes

Term
Endoplasmic Reticulum
Definition

The factory where the proteins are made, comes right off the nucleus, contains ribosomes.

-stores

-seperates

-serves

(as cells transport system)

Term
Smooth ER
Definition
lacks ribosomes
Term
Rough ER
Definition
has ribosomes embedded into the surface
Term
Mitochondrion
Definition

where Energy is made

(energy producing reactions take place in the Cristae)

Term
Ribosomes
Definition

makes proteins

"protein factories"

Term
Lysosomes
Definition

little vacules that digest waste.

transports waste to the cell membrane for removal.

Term
The cytoskeleton is made up of what?
Definition

-Microtubules

-Microfilaments

Term
Cells do 2 things:
Definition

-make stuff

-reproduce themselves

Term
Exocytosis
Definition
vesicle fusion at the plasma membrane, and it is the final step in the secretory pathway that typically begins in the endoplasmic reticulum (ER), passes through the Golgi apparatus, and ends at the outside of the cell.
Term
Mitochondria is...
Definition

"Power Plant" of the cell

where energy is produced

Term
Microtubules
Definition
control size & shape and intracellular transport
Term
Microfilaments
Definition
provide for movement. move to create muscle movement in cells.
Term
Cell membrane
Definition
The outer covering of the cell consisting of a lipid bilayer with proteins embedded in it.
Term
Diffusion
Definition

Movement of Molecules

 

 

Term
passive diffusion
Definition

molecules move randomly away from the area where they are MOST concentrated.

(spread out evenly/distribute evenly

Term
Spontaneous Kinetic energy
Definition
the energy produced by the molecules d/t it's movement
Term
Active diffusion
Definition

particles reach uniform concentration by means of their spontaneous kinetic energy.

*Lipid soluable molecules (O2,Carbon dioxide, alcohol, fatty acids) can diffuse across the membrane in order to make uniform concentrations of what it wants.

Term
Osmosis
Definition

the movement of water from a region of greater concentration to a region of lesser concentration

*Depends on particle concentration*

-water wants to be "evenly distributed" the more particles, the more water!

Term
Which way will the water move???
Definition
water will follow the solutes!
Term
Water diffuses...
Definition
From the place w/ lots of water to the place w/ less water!!!
Term

In Osmosis, WATER FOLLOW SOLTUES!

what is the "pull" of the particles called?

Definition

oncotic or

colloid osmotic

Term
If Na+ diffuses into the cell, what will the water do???
Definition
The water will follow it!
Term
The cells Na+/K+ pump sends the Na+ back out, what will the water do now???
Definition
the water will follow it back out until it's evenly distributed
Term
Facilitated Diffusion
Definition
molecules diffuse across a membrane WITH HELP by forming a vacuole or attaching to the protein
Term
Pinocytosis
Definition

a vacuole forms!

(to get in/out of the cell)

Term
Carrier/Transport proteins proteins
Definition

-Non-lipid solublethat need help through the membrane

-They combine w/ a carrier protein and are carried across

 (helps drag something in/out of cell)

Term
Carrier protein vs pinocytosis
Definition

*Carrier protein = an actual chemical bond takes place *Pinocytosis = no chemical bond just passing its way in the molecule

 

 

Term
Active transport
Definition

moving something in/ or against the gradient

-results in uniform concentration

-cell processes require uneven concentrations in order to be carried out

-high concentrations of K+ are needed to carry out intercellular processes

Term
What is used to move substances into or out of the cell for use?
Definition
ATP "Energy!!"
Term
There are 2 forms of Active Transport, name them?
Definition

-Primary

-Secondary

Term
Primary Active transport
Definition
-ATP is used directly to move a substance against the concentration gradient
Term
Secondary Active transport
Definition

-the energy created by primary active transport is harnessed used to facilitate the transport of a second substance

-usually involves sodium because large Na+ gradients occur frequently in normal metabolism.

Term
Primary active transport (recap)
Definition
uses energy to move something in/out of the cell
Term
Secondary active transport (recap)
Definition
harnesses energy from primary and uses it to transport something else
Term

Secondary Active Transport

(2 kinds)

Definition

Co-transport

Counter-transport

Term
Co-transport
Definition
moving in the same direction
Term
Counter- transport
Definition
going in opposite directions
Term
Cell Communication
Definition

-takes place by a messenger (neurotransmitters, proteins ect)

-a messenger molecule attaches to receptor proteins on the cell surface

-receptors span the cell membrane

Signal Transduction = the message is converted and moved across the membrane to effect a change within the cell.

 

Term
Receptor Regulation
Definition

*can be up/down according to your needs.

 

*up regulation = more receptors are present when low levels of messengers are available

 

*down regulation = few receptors are available when high levels of messengers are present

(as in Thyroid levels)

Term
Types of Receptor Proteins (3)
Definition

-G-protein linked receptors

-Enzyme linked receptors

-Ion channel linked receptors

Term
G-protein linked receptors
Definition
activation creates a second messenger to turn on internal cellular systems
Term
Enzyme linked receptors
Definition
very directly mediate cellular responses
Term
Ion channel linked receptors
Definition

rapid synaptic signaling

(neurotransmitters)

Term
G-Protein linked receptors
Definition

"Second Messenger"

its a 2 step process to create some sort of internal response.

Term
G-Protein Coupled Receptors
Definition
 receptorsthat sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. they pass through the cell membrane.
Term
Enzyme Linked Receptor
Definition
hook up with a receptor and make something happen inside the cell, a desired effect.
Term

Ion Channels

 

when you need change fast!)

 

Definition

-rapid ion exchange is needed for cellular processes

 

-the electrical change of ions such as Na+ and K+ make it difficult for these to pass through the lipd membrane

 

-special protein channels span the width of the lipid

 membrane (to allow these to pass through quickly.

 

-the proteins undergo conformational changes to form open channels for the selected ion.

Term
Non-Gated (LEAK) channel
Definition
there is an opening in the cells membrane
Term
Ligand(piece of protein) Gated Channel
Definition
opens only when appropriate ligand comes along
Term
Voltage gated channels
Definition
open/close according to the voltage outside the cell.
Term
Cell Metabolism
Definition

The process that provides fuel for cellular processes.

*Converts (protein, carbs & fats to ATP)

Term
Anaerobic
Definition
without oxygen in the cytoplasm
Term
Aerobic
Definition
with oxygen in the mitochondria
Term
What is the Glycolytic path?
Definition

The basis for Anaerobic metabolism

 

*uses 2 molecules of ATP

*creates 4 ATP

& pyruvic acid

Term
When ANAEROBIC conditions persist.....
Definition

(a little is ok but..)

Pyruvic acid builds up & turns to LACTIC acid.....TOXIC!

Term

AEROBIC

Citric acid cycle is a big producer of what??

Definition

ATP

"energy"

Term

T or F

Aerobic creates a greater amount of energy?

Definition
TRUE!
Term
ATP-High energy bonds formed in Citric Acid cycle are released to convert, what into what?
Definition
ADP into ATP
Term
Membrane potentials
Definition

-nerve and muscle tissue

-changing electrical gradients cause cell functions

*glandular release of hormones

*muscle movement

*neurological functions

Term
When an action potential occurs the cell is said to....
Definition
Fire
Term
An action potential "cell firing" occurs in response to what?
Definition

1) chemical activity (neurotransmitters)

 

2) electric activity (change in ion concentration)

 

3) physical activity (direct stimulation)

Term
explain the Basics of Cell Firing
Definition

-cells begin with a negative charge, resting potential

-Stimulus causes Na+ channels to open up

-Na+ diffuses in making cell more positive.

Term
Depolarization
Definition

-at the threshold potential, more Na+ channels open up.

 

-Na+ rushes in, makes cell very positive! (depolarization)

 

-action potential responds by contracting the action WILL occur!

Term
Repolarization
Definition

K+ channels open

K+ diffuses out making the cell negative again (repolarization)

Na+/K+ pump removes the Na+ from the cell and pumps the K+ back in

Term

No Acetylcholine

what's this mean?

Definition
paralysis
Term

no Acetylcholinesterase

Definition
stiffness
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