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one globular subunit of microtubules
binds GTP but it cannot be hydrolyzed
makes up the - end of the microtubule filament |
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one globular subunit of microtubules
Binds GTP and can be hydrolyzed
makes up the +end of the microtubule filament |
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| part of the IF family, very diverse, related to desmosomes which are cell to cell contact. |
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| Tubulin ring complex, it binds to the - end where the microtubule is connected to the MTOC. It initiates nucleation. |
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| Actin Relate Proteins, nucleate actin filaments from the - end. Nucleation normally occurs near the plasma membrane. It nucleates best when attached to another filament so a meshwork begins to form. |
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| when WASp binds to Cdc42 it changes conformation and allowsARP to bind and nucleation to begin. |
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| assemble unbranched actin filaments. Associated with the + end. |
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| binds actin monomers and prevents assembly, they can't hydrolyze their ATP |
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| binds actin monomers, it binds to the face that would normally bind the - end. this makes the monomer more likely to bind the + end and this makes assembly go faster. |
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| binds heterodimers- prevents their addition to the + end. |
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| severs actin filaments, its activated at high Ca levels. it doesn't require extra energy input |
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| severs microtubule filaments, 13 bonds must be broken. Requires ATP |
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| Microtubule associated proteins, bind along the side of the microtubule, stabilize against disassembly, abundant in neurons. |
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| produces evenly spaced MT bundles |
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| Forms MT bundles more closely packed |
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| Catastrophe factor, increases frequency of catastrophe. |
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| binds to actin subunits and filaments- twising the helix tighter and causing instability. |
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| elongated protein that coats the actin filament and stabilizes it. |
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| Binds to the + end of actin where the filaments grow |
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| binds to the - end where the actin filaments desassemble |
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| from Z disc to Z disc, muscle fibers. built from CapZ and actin and myosin. |
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| dictates the length of the actin filament |
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| acts like a spring that positions the thick actin filament |
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| binds actin and tropomyosin |
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| myosin light chain kinase- the myosin head must be activated in order for ATP to bind. it activates myosin. |
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| moves toward the + end, ATP driven, one head group is always attached. |
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| moves toward the - end, moves on MTs. |
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| binds to Dynein to bind the cargo |
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| localized to the buddin gyeast cell so that it ends up in the daughter cell. |
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| Rho family, GTPase, activates WASp and ARP complex to initiate actin polymerization, Also can activate Rho and formin. |
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