Term
| passive vs active movement |
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Definition
| cell sheets/flow vs cilia/crawling etc |
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Term
| adhesion dependent cell movement steps |
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Definition
extension (lamelipodia/filopodia)
attachment (receptor/adhesion/substrate)
contraction (ligand, receptor, actin binding, actin and myosins) |
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Term
| cell migration vs. axon growth |
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Definition
| cell body is not pulled into the extending cell process in axon growth |
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Term
| Roles of environment molecules on migrating cells |
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Definition
- adhesive substrate
- generate space
- attractive cues: chemotaxis/chemotropism
- repulsive cues
- guidepost (initiate change in cell)
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Term
|
Definition
| immobilized, e.g. collagens |
|
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Term
|
Definition
| 28 types, fibrous with 3 polypeptides intertwined, provides anchor, in connective tissue |
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Term
| noncollagen glycoproteins in ECM |
|
Definition
| substrate for cell migration, binding sites for collagen, GAGs, membrane receptors, e.g. laminin |
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Term
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Definition
unbranched polysacharid chain of repeating
disaccharide units, often sulfated
- most are covalently bound to a protein core making
it part of a proteoglycan
- hyaluronic acid is an exception (i.e. not a
proteoglycan)
- polyanionic nature of GAGs holds counter ions
increasing the hydration and thus the cell free space
of a tissue
- e.g. heparin sulfate GAG, chondroitin sulfate GAG |
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Term
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Definition
- GAGs (few or many) bound to a protein core
- may be several GAG types, but named by most
common GAG type
- can bind to cells and other ECM components
- many bind growth factors
- e.g. heparan sulfate pg., chondroitin sulfate pg. |
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