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Cell metabolism
Nucleic Acid Structure
18
Science
Undergraduate 2
09/18/2013

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Term
Criteria genetic material must meet
Definition
  • Information: must contain information necessary to make and entire organism
  • Transmission: must be passed from parent to offspring
  • Replication: must be copied
  • Variation: must be capable of changes
Term
What is a nucleotide?
Definition
The repeating structural unit of DNA and RNA
Term
What are the three components of a nucleotide?
Definition
  1. A phosphate group
  2. A pentose sugar
  3. Anitrogenous base

Adenosine monophosphate (AMP)

Adenosine diphosphate (ADP)

Adenosine triphosphate (ATP)

Term
What is a nucleoside?
Definition

composed of two parts

  1. A base
  2. A sugar

Adenine+ribose=adenosine

Adenine+deolyribose=deoxyadenosine

Term
What forms the backbone of DNA?
Definition

the phosphates and sugars

 

these are connected with covalent bonds making them strongly bonded

Term
Purines
Definition

have two carbonchains

(Guanine and Adenine)

Term
Pyrimidines
Definition

Smaller and simpler than purines

(Thymine and Cytosine)

(Uracil in RNA replaces Thymine)

Term
How many nucleotides does it take to code for one amino acid?
Definition

Three

(every third letter)

Term
How are purines and pyrimidines bonded?
Definition

Bonded by hydrogen bonds

purine bonds to a pyrimidine

 

A-T (double hydrogen bond)

C-G (triple hydrogen bond)

T-A (double hydrogen bond)

G-C (triple hydrogen bond)

and in RNA

U-A


 

Term
What are the two types of sugars and what genetic material do they belong to?
Definition
  • Deoxyribose (DNA) has one less hydrogen than ribose
  • Ribose (RNA) has three OH
Term
How are the two strands of DNA directionally situated?
Definition

directionalitly parallel

5' to 3'

Term
Describe the double helix of DNA...
Definition
  • two strands are twisted around a common axis
  • 10 bases at 3.4 nm per complete turn
  • the helix is right-handed (as it spirals away it turns clockwise)
Term
How is DNA stabalized and twisted into a double helix?
Definition
  • hydrogen bonding between complementary bases
  • base stacking (bases are oriented so that flattened regions are facing each other)
Term
What is the point of DNA's double helix?
Definition
  • certain proteins can bind in either the major or minor grooves
  • the 3D structure helps the large amount of DNA needed fit into a compact space
Term

What protein does DNA wind around?

What is the point of a DNA-binding protein?

Definition
  • Histone protein
  • to extensively compact DNA
Term
How long are RNA strands?
Definition
several hundred to several thousand nucleotides in length
Term
Is it possible for RNA to form anything besides single strands?
Definition

Yes

short double-stranded regions

(due to complementary base pairings)

 

They are typically

  • righ handed
  • A form with 11 to 12 base pairs per turn
  • different types of secondary structures arise
Term
What are the kinds of RNA secondary structures?
Definition
  • noncomplementary regions: bases projecting away from double stranded regions (bulge loop and intemal loop)
  • multibranched junction
  • stem-loop (aka hair pin)
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