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Cell Injury
terminology for basic cell injury
76
Physiology
Professional
08/31/2010

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Term
hyperplasia
Definition
increase in number of cells resulting in hypertrophy of an organ
Term
hypertrophy
Definition
increase in the size of the cells in an organ due to an increase in the amount of proteins
Term
atrophy
Definition
decrease in the size of an organ usually from the loss of nutrients or use
Term
metaplasia
Definition
replacing one cell type with another type that is more fit to withstand a constant irritant
Term
Inherited Disease
Definition
caused by faulty genetic information
Term
Familial Disease
Definition
one that tends to run in families, some are genetic and some are from upbringing
Term
Congenital Disease
Definition
something you are born with, not always genetic could be from injury in womb as in Fetal Alcohol syndrome
Term
Toxic Disease
Definition
due to a poison
Term
Traumatic Disease
Definition
caused by injury
Term
Degenerative Disease
Definition
caused by degneration of the organ or tissue
Term
Immunologic Disease
Definition
caused by an abnormal process of the immune system
Term
Neoplastic Disease
Definition
caused by uncontrollable cell proliferation, tumor, can be malignant or benign
Term
Metabolic Disease
Definition
caused from a problem with metabolism, usually genetic
Term
Nutritional Disease
Definition
caused by a nutritional imbalance
Term
Iatrogenic Disease
Definition
produced inadvertently from being treated for an initial disease
Term
Idiopathic Disease
Definition
disese we do not know the cause of
Term
etiologic agent
Definition
cause of a disease
Term
pathogenesis
Definition
sequence of events that occur in the development of the disease
Term
symptoms
Definition
purely subjective, only patient can see or know there is a problem
Term
Signs
Definition
something that others can see is wrong
Term
remission
Definition
decrease in intensity of a disease
Term
exacerbation
Definition
disease gets worse
Term
complication
Definition
secondary problem caused from initial problem
Term
sequela
Definition
persisting aftereffect from the first problem even after its gone
Term
parenchyma
Definition
functional cells of an organ
Term
stroma
Definition
supportive cells of an organ
Term
healing
Definition
process by which damaged tissues are restored toward normal
Term
resolution
Definition
complete restoration of function to an organ
Term
epidemiology
Definition
study of epidemics
Term
hypoxia
Definition
lack of adequate levels of oxygen
Term
7 causes of injury
Definition
hypoxia, trauma, infectious agents, chemicals, toxins, nutrion, immunologic attack
Term
dysplasia
Definition
stage of great variability in size, shape, and function
Term
hypoplasia
Definition
partial failure to develop mornally
Term
aplasia
Definition
total lack of development
Term
agenesis
Definition
total lack of development
Term
Cloudy Infiltration
Definition
1st sign of cell injury, cytoplasm takes on cloudy appearance and swell the cell
Term
hydropic degeneration
Definition
little vacuoles appear in cytoplasm
Term
Lipofuscin Infiltration
Definition
abnormal substance in cell that makes the organ take on a yellow-brown appearance if damaged heavily, left after the break down of organelles
Term
hyaline infiltration
Definition
has a pink wax-papery appearance like a scar
Term
fatty infiltration
Definition
refers to accumulation of fat in the cytoplasm, very ominous sign
Term
calcifications
Definition
casued when kidney cannot excrete calcium or all salts are precipitated out, hardens an organ
Term
calculi formation
Definition
calcification that occurs in ducts and causes a stone to form
Term
algor mortis
Definition
cooling to environmental temperature
Term
livor mortis
Definition
gravity pulls blood into pools in the body a few hours after death
Term
rigor mortis
Definition
tightening of muscles as the sarcoplasmic reticulum releases Ca during deterioration
Term
pyknosis
Definition
very dense and intense staining as DNA condenses into a solid shrunken mass
Term
karyorrhexis
Definition
bursting of the nucleus into fragments
Term
karyolysis
Definition
lyses of the nucleus, fading of chromatin
Term
coagulative necrosis
Definition
area of dead organ while the rest remains functional
Term
liquefactive necrosis
Definition
infection where leukocyes digest the organ and leave a pussy hole
Term
caseous necrosis
Definition
cheese-like yellowish buildup
Term
fibrinoid necrosis
Definition
immune reaction with blood vessels in which antigens are deposited in arterial walls
Term
fat necrosis
Definition
fat destruction from pancreas
Term
epitheloid cells
Definition
flattened macrophages
Term
granuloma
Definition
localized area of chronic inflammation
Term
5 signs of inflammation
Definition
calor, dolar, rubor, loss of function, tumor
Term
inflammation
Definition
local reaction of tissues to injury
Term
5 types of inflammatory mediators
Definition
vasoactive, plasma factors, arachadonic acid derivatives, leukocyte products, and miscellaneous
Term
2 vasoactive amines
Definition
histamine and seratonin
Term
3 plasma factors
Definition
kinins, complement, and clotting factors
Term
2 Miscellaneous mediators
Definition
cytokines and PAF (platelet activating factor)
Term
caspases
Definition
cystein proteases, family of proteins known to initiate apoptosis
Term
autophagy
Definition
lysosomal digestion of the cell's own components
Term
4 results of ischemia
Definition
no Na pump (cell swelling), no Ca pump (calcification), ribosomal detachment (no protein synthesis, anaerobic glycolysis (drop of pH)
Term
ischemia
Definition
inadequate levels of oxygen without the ability to perform anaerobic respiration
Term
3 levels of stress
Definition
not damaging, infiltrations and degenerations, and irreversible/lethal damage
Term
margination
Definition
blood flow slows through vessels and macrophages start bouncing off the walls
Term
pavementing
Definition
macrophages bind to receptors on the vessel walls
Term
hemostasis
Definition
stagnation of blood flow
Term
hyperemia
Definition
capillary beds open as arterioles dilate
Term
edema
Definition
fluid and molecules move from the capillaries to the site of injury causing swelling
Term
transudate
Definition
fluid leaving the capillary beds during inflammation has a low protein content as it is mostly plasma
Term
exudate
Definition
fluid leaving capillary beds has a high protein content and can even include cells
Term
basophil
Definition
granulated WBC that circulates in the blood, full of inflammatory mediators, not phagocytic
Term
mast cell
Definition
basophil that is permanently stationed in a tissue
Term
anaphylatoxins
Definition
cytotoxic portions of the complement system formed from amino acid cleavage, initiate histamine release and other inflammatory responses
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