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Cell Biology Overview
Review Questions
105
Physiology
Undergraduate 4
12/24/2012

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Term
The smallest unit that scientists agree is alive is the
Definition
cell
Term
The region in a human cell that houses the bulk of the genetics material is the
Definition
nucleus or nuclear region
Term
Most of the cellular machinery in human cells is in the
Definition
cytoplasm or cytoplasmic region
Term
Cellular interactions with the environment are controlled by which region of the cell?
Definition
membrane or membrane-associated region
Term
The basic structre of a cell's membrne is a __(1)__ bilayer with associated proteins that can either __(2)__ or __(3)__
Definition

(1)  phospholipid

(2)  integral

(3)  peripheral

Term
Receptors in the cell's surface tend to be made of
Definition
protein
Term
The moles that allow cells to join and adhere to one another and or objects are made of ______.
Definition
protein
Term
When a cell is attached to a bustrate, the cell's membrane is protectedfrom riing by ____ which pass the external forces from the exterior to the interior of the cell.
Definition
membranes proteins
Term
_________ are membrane junctions which prevent passage of materials between two cells.
Definition
Tight junction
Term
________ are membrane which allow force to be passed from cell to cell without separation of, or damage to, the cellular membranes.
Definition
Desmosomes
Term
________ are membrane junctions which contain hollow channels within them that allow ions to pass through from cell to cell.
Definition
Gap junctions
Term
When a molecule moves from an area of high concentration to an area of low concentration, the proces is called
Definition
diffusion
Term
Molecues can passively diffuse that the plasma membrane with the aide of __(1)__ proteins, which form a tunnel that specific molecules can travel, and __(2)__ proteins, which bind to a molecule and chnage shape so that unbinding occurs on the opposite side of the membrane. 
Definition

(1) channel

(2)  carrier

Term
If a molecule can only pass through a membrane with the assistance of a membrane protein, but the direction of its travel is controlled only by its concentration, the process is called _______ diffusion. 
Definition
facilitated
Term
When water moves from an area where there is more water to an area where there is less, the process is called
Definition
osmosis
Term
_______ is the diffusion of water molecules
Definition
Osmosis
Term
When a cell is surrounded by solution of equivalent solute concentration, the solution is said to be __(1)__ to the cell, and the net movement of water is __(2)___.
Definition

(1) isotonic

(2) absent

Term
When a cell is surrounded by solution of high solute concentration, the solution is siad to be __(1)__ to the cell, and the net movement of water is _(2)__.
Definition

(1)  hypertonic

(2) out of the cell

Term
When a cell is surrounded by solution of lower solute concentrations, the solution is said to be __(1)__ to the cell, and the net movement of water is __(2)__.
Definition

(1)  hyptonic

(2) into the cell

Term
____ is the passage of liquids and solutes through membranes due to differences in pressure, a process which is important in the kidney
Definition
Filtration
Term
When energy is being used to move a solute from low to high areas of concentration, the process is called _______.
Definition
active transport
Term
The concentration of sodium is highest [outside/inside] the cell, while for potassium, the reverse is true. 
Definition
outside
Term
Sodium and potassium gradients are maintained by an active-transport protein called the sodium-potassium pump, which moves __(1)__ sodiums out of the cell for every __(2)__ potassium ions brought in. 
Definition

(1) 3

(2) 2

Term
The energy to operate the sodium-potassium pump comes from the hydrolysis of __(1)__, which transfers a __(2)__ to the transport protein. 
Definition

(1) ATP

(2)  phosphate bond or high-energy phosphate bond

Term
In ________, interactions between vesicle proteins and plasma membrane proteins cause a vesicle to merge with the plasma membrane and discharge its contents to the cell's exterior. 
Definition
exocytosis
Term
In ______, clarthrin-coated regions of the cell's exterior invaginate and form vesicles which bring a portion of the extracellular material into the cell.
Definition
clathrin-mediated endocytosis
Term
When a vesicle is formed on one side of the cell to endocytose extracellular material, and actually transverses the cell to leave on the other side, the process is called ______.  This proces is important in digestion.
Definition
transcytosis.  
Term
Endocytosis, exocytosis, and transcytosis are all examples of ______ transport.
Definition
active.
Term
A difference in the number of positive and negative charges on the two sides of a membrane is referred to as the ________.
Definition
membrane potential
Term
The two factors that act in opposite ways to stablize the resting membrane potential are __(1)__ and __(2)__.
Definition

(1) concetration gradients (or diffusion)

(2)  electrostatic attraction. 

Term
The two major ions responsible for the membrane potential in human cells are __(1)__ and __(2)__.
Definition

(1)  sodium

(2)  potassium

Term
The glycocalyx is composed of _____ molecules (a class of macromolecule) attached to proteins and lips on the cell surface.
Definition
carbohydrate
Term
Cells sense contact with other cells and with surfaces, and adhere to substranes and other cells, largely via the use of carbohydrate-rich macromolecules in the cell membrane which together compose the ________.
Definition
glycocalyx
Term
The three major signal types recognized by membrane receptors are __(1)__ signals, ___(2)__, and __(3)__.
Definition

(1) chemical

(2) elecrical

(3) contact

Term
A common function of all _____ is to transmit an external event, as a signal, into the cell to allow the cell to respond.
Definition
membrane receptors
Term
The entire region between the cellular nucleus and the membrane is called the __(1)__ , the liquid portion is called the __(2)__, and the membrane-enclosed compartment in which specific functions are localized and called __3)__.
Definition

(1) cytoplasm

(2) cytosol

(3) organelles

Term
If a particle in the cell's cytoplasm can be seen with light microscopy, it is called an ______. 
Definition
inclusion
Term
Mitochondria have ________(have many?) membranes, each of which is a bilayer. 
Definition
two
Term
The innermost membrane of mitochondria is folded, forming wrinkles called _______.
Definition
cristae
Term
The major (not only) function of mitochondria is to completely oxidize fuels and to capture the energy in a molecule called ________. 
Definition
ATP
Term
_________ are hugh macromolecules compose of RNA and protein, whose function is to synthesize protein.
Definition
Ribosomes
Term
Cytosolic proteins are made by __(1)__ ribosomes, while proteins destined for export, or use in membrane, are made by __(2)__ ribosomes.
Definition

(1)  free

(2)  membrane bound (or ER bound)

Term
The rough endoplasmic reticulum is distinguised by the presence of _____ on its surfae, and is responsible for making integral membrane proteins, secreted proteins, and phopholipids.
Definition
ribosomes
Term
Ribosomes become bound to the membrane of the rough ER after they have started making protein due to the presence of a _______ on the newly made protein which binds to receptors called SRPs (Signal Recognition Particles) on the ER surface.
Definition
signal sequence
Term
The function of the _____ ER varies greatly from cell type to cell type, and can include lipid metabolism, steroid synthesis, calcium storage and release, and others.
Definition
smooth
Term
Proteins leaving the rough ER are transported to the ______ for modification, packaging, and trasport to the appropriate location.
Definition
Golgi apparatus
Term
The series of organelles that are able to exchange membrane components with one another are collectively known as the _______.
Definition
endomembrane system
Term
The organelles within the cell whose main functions are digestion and hydrolysis are the _________.
Definition
lysosomes
Term
The organelles which isolate hazardous chemical reactions within the cell, especially those producing free radicals, are called ________.
Definition
peroxisomes
Term
The three principle components of the cytoskeleton are __(1)__, __(2)__, and __(3)__.
Definition

(1)  microfilaments

(2)  intermediate filaments

(3) microtubules

Term
The primary functions of ______ are to brace and strengthen the cell's surface and to attach to cellular adhesion molecules which allow binding to substrates and other cells.  They also function in endocytosis and exocytosis. 
Definition
microfilaments
Term
The semi-parmanent structural framework of the cell, which transmit force from one point in the membrane to others, allowing cells to spread a stretching force across a wide region and to other cells, are the _______.
Definition
intermediate filaments
Term
The dynamic, hollow tubes which help to determine the overall shape of the cell and along which organelles move as if on a conveyor belt are the ________.
Definition
microtubules
Term
The molecules which use energy from ATP to move organelles along certain components of the cytoskeleton are called _______.
Definition
motor molecules
Term
The structures that organize and generate the microtubules for the mitotic spindle during mitosis and for cilia and flagella are called ________.
Definition
centrioles
Term
Short, cellular projections that allow the cell to move through their environment, or for human cells, to move fluid across their surface, are called _______.
Definition
citia
Term
The cytoskeletal components that give cilia their mobility and structural strength are _______.
Definition
microtubules
Term
The primary difference between cilia and flagella is _______.
Definition
length.
Term
The nuclear envelope consists of ______ (how many?) separate membrane bilayers?
Definition
two
Term
The outer membrane of the nuclear envelope is continuous with the ______.
Definition
rough E.R.
Term
The function of the _____ is to regulate which materials enter or leave the nucleus.
Definition
nuclear membrane
Term
Large molecules are transported into or out of the nucleus through _________.
Definition
nuclear pores
Term
Ribosomal RNA is produced in
Definition
nucleoli
Term
DNA wrapped around histones within the nucleus is called ______ because it could take up dyes and showe as a colored substance when a microscope was used.
Definition
chromatin
Term
The cell cycle can be divered into two major phases, __(1)__ and __(2)__.
Definition

(1) interphase

(2) mitotic or mitosis

Term
Interphase can be divered into three groups of events, __(1)__, __(2)__ and __(3)__.
Definition

(1)  G1 (or gap1)

(2) S (or synthesis)

(3) G2 (or gap 2)

Term
DNA is made during the _____ phase of the cell cycle.
Definition
S or Synthesis
Term
Cells that have permanently stopped dividing enter a phase of the cell cycle known as _______.
Definition
G0
Term
Cell growth and preparation for cell division occur during the __(1)__  and __(2)__ phases respectively.
Definition

(1)  G1

(2)  G2

 

Term
Replication or division of the nucleus is called ________.
Definition
mitosis
Term
Once there are two nuclei, the cell itself may divide into a process called ________.
Definition
Cytokinesis
Term
Mitosis consists of four phases.  In order they are __(1)__, __(2)__, __(3)__, and __(4)__.
Definition

(1)  prophase

(2)  metaphase

(3) anaphase

(4) telophase

Term
During _____, the nuclear envelope dissolves and the chromatin condenses.
Definition
prophase
Term
During ______, the individual chromosomes line up in the middle of the cell.
Definition
metaphase
Term
In _____, the sister chromatids separate.
Definition
anaphase
Term
In _____, a new nuclear envelope forms.
Definition
telophase
Term
DNA is made by enzymes called ________.
Definition
DNA polymerases
Term
During DNA synthesis, new nucleotides an only be added to the _______ end of the DNA.
Definition
3 foot
Term
The structure of DNA is anti-parallel, meaning that the strands are ________.
Definition
parallel, but pointed in opposite directions
Term
The ______ strand of DNA is made discontinuously (in small pieces).
Definition
lagging
Term
DNA polymerases require a _____ which is the cell is either a pre-existing piece of DNA, or a newly made piece of RNA.
Definition
primer
Term
When RNA is removed from the lagging strand during DNA synthesis, it is replaced by DNA everywhere except at the __(1)__ end of the strand.  It cannot be replaced there, because there is no __(2)__.
Definition

(1) 5 feet

(2)  primer

Term
A hereditary nucleic  acid sequence which contains the information needed to make a cellular component is called a ________.
Definition
gene
Term
In humans, _______ is the chemical which contains the original sequence information encoding proteins and other cellular components and which is the "master copy" that is passed on to future generations.  
Definition
DNA
Term
In humans, ________ is a disposable copy of the nucleic acid sequence which contains the information encoding proteins and other cellular components.  It is used by the ribosomes in the cytoplasm to create a protein with the correct amino acid sequence. 
Definition
mRNA
Term
_______ is a form of RNA that carries amino acids to the ribosome during protein synthesis.
Definition
tRNA
Term
_______ is a form of RNA that is a physical component of the ribosome.
Definition
rRNA
Term
During __(1)__, the sequence of the DNA is copied into RNA.  During __(2)__, the ribosome uses the nucleotide sequence to create a protein with the correct amino acid sequence.
Definition

(1) transcription

(2)  translation

Term
Codons are found in __(1)__ RNA, while anticodons are found in __(2)__ RNA.
Definition

(1)  messenger

(2)  transfer

Term
Translation occurs in which part of the cell?
Definition
Cytoplasm
Term
Non-functional organelles are degraded by _______.
Definition
lysosomes
Term
Proteins which are no longer functional are marked for degradation by the addition of ________.
Definition
ubiquitin
Term
The _____ is an organized, extracellular mesh of varying density in which cells are found.
Definition
extracellular matrix
Term
At the DNA level, the difference between a liver cell and a brain cell, is that they __(1)__, although they have the same __(2)__.
Definition

(1) have different genes active

(2) DNA

Term
The development of specific and distinctive features in a cell (example, when a cell becomes a liver or a brain cell) is called ________.
Definition
differentiation or cell differentiation
Term
In organisms that _____, unrepaired, damaged parts are not replaced.
Definition
age
Term
In organisms that age, repair of damage is _______.
Definition
imperfect
Term
In organsims that _____, life processes which have short term benefits but which have negative effects in the long term are allowed to occur
Definition
age
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