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Cell Bio Chapter 15
Cytoskeleton
38
Biology
Undergraduate 4
07/25/2013

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Term
Size of microtubules
Definition
25 nm
Term
size of intermediate filaments
Definition
8-10 nm
Term
size of microfilaments
Definition
6 nm
Term
Microtubules (6)
Definition
1) inhibition of polymerization prevents mitosis
2) can form dimers and trimers
3) critical concentration of heterodimers determines weather it grows
4) radiates out from centrosome
5) found in cilia
6) stabilized by MAPs
Term
Intermediate filaments (3)
Definition
1) most stable
2) only type without polarized in
3) different subtypes are indicative of tissue type
Term
microfilaments (7)
Definition
1) involved in myosin based contraction
2) responsible for the gelatinous consistency of cytosol
3) most abundant protein in cell
4) found in stress fibers
5) smallest diameter
6) monomer binds ATP
7) polymerization regulated by monomeric G proteins
Term
inhibition of polymerization prevents mitosis
Definition
microtubules
Term
can form dimers and trimers
Definition
microtubules
Term
radiates out from centrosome
Definition
microtubules
Term
critical concentration of heterodimers determines weather it grows
Definition
microtubules
Term
found in cilia
Definition
microtubules
Term
stabilized by MAPs
Definition
microtubules
Term
most stable
Definition
intermediate filaments
Term
only type without a polarized end
Definition
intermediate filaments
Term
different subtypes indicative of tissue type
Definition
intermediate filaments
Term
involved in myosin based contraction
Definition
microfilaments
Term
responsible for the gelatinous consistency of cytosol
Definition
microfilaments
Term
most abundant protein in cell
Definition
microfilaments
Term
monomer binds ATP
Definition
microfilaments
Term
polymerization regulated by monomeric G proteins
Definition
microfilaments
Term
found in stress fibers
Definition
microfilaments
Term
smallest diameter
Definition
microfilaments
Term
Cross-sectional view of a doublet microtubule
Definition
13 protofilaments + 10 protofilaments
Term
Centrosome
Definition
a pair of centrioles surrounded by pericentrolar material
Term
Just above critical concentration
Definition
elongation from the positive end
Term
Way over the critical concentration
Definition
elongation from both ends
Term
2 ways a drug could interfere with microtubule function
Definition
1) it could prevent spindle formation
2) it could damage the spindle after it is formed (cause a depolymerization of the spindle leading to paracrystalline arrays)
Term
2 types of MTOC in mammalian cells
Definition
1) centrosome
2) basal body
Term
Synonym for actin
Definition
microfilaments
Term
2 types of microtubules
Definition
1) cytoplasmic microtubules
2) axonemal microtubules
Term
Axonemal microtubules (3)
Definition
1) cilia
2) flagella
3) basal bodies
Term
MAP =
Definition
mictorubule associated proteins
Term
What do MAPs do?
Definition
stabilize or bundle microtubules
Term
MTOC
Definition
microtubule organizing center
Term
2 types of microfilaments
Definition
1) g-actin (monomer) = gelatinous actin
2) f-actin = filamentous actin
Term
Highly conserves
Definition
microfilaments
Term
Filamentous actin (3)
Definition
1) lamellapodia
2) filapodia
3) stress fibers
Term
Keratin
Definition
intermediate filament
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