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• Ectoderm is the outermost layer and it gives rise to: • the entire nervous system (PNS, CNS) • all hair, nails and skin (epidermis) • sensory epithelium of the eye, ear and nose • the pharynx • the dental enamel |
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• Mesoderm is the middle layer and it gives rise to: • muscle • connective tissue [primordial embryonic connective tissue] is also called mesenchyme • bone and cartilage • blood vessels Note: CL+CP results from a disturbance to mesoderm |
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• Endoderm is the innermost layer and it gives rise to: • the linings of the digestive and respiratory tracts |
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The term primordial means the original tissue from which something is formed, derived.
The anterior neuropore, which is the anterior opening of the developing neural tube. This neural tube is the primordium for the central canal of the spinal cord. |
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Branchial Apparatus: Buccopharyngeal Membrane (aka Orophyaryngeal membrane) |
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the oropharyngeal membrane separates the stomodeum (the primitive mouth opening) from the primitive pharynx; this membrane ruptures at about 4 weeks gestation, allowing communication between the primitive gut and the amniotic cavity |
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The frontonasal process differentiates to form the nasolateral and nasomedial processes. |
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The nasal placode is a thickening of the primordial ectoderm, around which the lateral nasal and medial nasal processes develop. [ |
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The otic pit will migrate medially and become the external auditory meatus |
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The medial nasal (aka nasomedial) processes fuse in midline and form the primary palate; the primary palate is also called the intermaxillary segment, the premaxilla, or the pre-palate; it gives rise to: *the philtrum and mid-portion of the upper lip *the four incisor teeth and *associated maxillary alveolus |
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the maxillary processes form the bulk of the [lateral parts of the] upper lip; the upper lip is formed by the merging of the maxillary processes with the nasomedial processes; |
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The mandibular processes differentiate to form the mandible, the anterior 2/3 of the tongue** [aka the oral tongue] and the lower lip
** the posterior part of the tongue comes from the 2nd through 4th branchial arches
structures derived from the mandibular process are innervated by the mandibular division of CN V, the trigeminal nerve |
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The nasal pit will migrate medially and become the nostril. The nasal pit is part of the frontonasal process |
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The naso-optic furrow is where the maxillary and lateral nasal processes meet, and therefore the site of oblique clefting. |
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Four branchial arches can be seen on the surface of the head and neck area in the 4 week-old embryo;they are separated from each other by branchial grooves • branchial arches are numbered in a cephalad to caudal direction as arches 1 through 6; the branchial arches support the lateral walls of the anterior foregut, primitive pharynx; the pharyngeal pouches evaginate from the primitive pharynx;Note: Each branchial arch differentiates and gives rise to muscles, cartilages, bones, and blood vessels; certain cranial nerves [CNs] (V, VII, IX, X) grow from the brain into specific branchial arches. In fact, CNs V, VII, IX and X are associated with arches 1, 2, 3, and 4, respectively. (see pg. 30 of lecture 5 for detailed photo and explanation of arches. |
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If we draw an imaginary wedge from the incisor teeth back to the incisive foramen, that segment of prolabium, incisor teeth, alveolus and palate is the primary palate.the medial nasal (aka nasomedial) processes fuse in midline and form the primary palate; the primary palate is also called the intermaxillary segment, the premaxilla, or the pre-palate. for the primary palate, the direction of closure is downward and forward with the lip closing last; therefore, the mildest form of primary palate clefting is a lip notch, often considered a microform of clefting |
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secondary palate closure starts between the 7th and 8th weeks and is completed by the 12th week of gestation; it includes: • the hard palate posterior to the incisive foramen • the soft palate and • the uvula The secondary palate develops from the two (2) lateral palatine processes, which are shelf-like outgrowths of the maxillary processes. |
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See pg. 16-19 of module 5. Too much info for this card! |
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Lateral clefts [aka transverse clefts] occur because of lack of fusion between maxillary and mandibular processes; they are often seen as a component of a syndrome, especially the spectrum of “hemifacial microsomia.” Clinically, the mouth appears large due to the lateral/labial corner extension which can be unilateral or bilateral; and the lateral facial cleft is, therefore, often labeled as macrostomia [note the relationship between stomodeum and macrostomia] |
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See other set of note cards |
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