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Case4
N/A
46
Pathology
Graduate
04/22/2011

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Term
4 types of obstructive disorders?
Definition
Adhesions, Intessusception, Volvus, Hernias
Term
Why do hernias occur?
Definition
Defect in peritoneal wall
Term
If you have had surgery, infxn or peritoneal inflammation which of the obs d/o do you prob have?
Definition
Adhesion
Term
What obs d/o is MC in kids esp after a rotovirus infxn?
Definition
Intussusception
Term
For intussusception what is the tx for kids and for adults?
Definition
Kids: barium enema
Adults: Surgery
Term
Volvulus MC occurs in
Definition
Redudant sigmoid colon, then cecum, then sml bowel, then stomach
Term
What are poss complications of obstructive d/o?
Definition
Ischemia, obstruction, infarcation
Term
What are causes of Hemorrhoids?
Definition
Venous statis of preg, Potal HTN, straining at stool in constipated pts
Term
Ext hemorrhoids involve what? Internal hemorrhoids?
Definition

Ext: inf hemorrhoidal plexus, below anorectal line

Inf: Superior hemorrhoidal plexus, in distal rectum

Term
What is assoc w low fiber diets?
Definition
Sigmoid diverticulitis, hemorrhoids, colonic adenoma and colonic adenocarcinoma
Term
Where do diverticulae occur?
Definition
Where nerves and & BVs penetrate colonic wall
Term
Sml Bowel Adenomas are MC located
Definition
Near ampulla of Vater
Term
What is more common small bowel adenomas or colon adenomas?
Definition
Colon adenomas
Term
Carinoid tumors arise from
Definition
Neuroendeocrine cells that release hormones (5HT)
Term
Sx w/ obs d/o?
Definition
Periumbilical pain, N/V, dilated loops of bowel
Term
When do you get Carcinoid s/o and what are the Sx?
Definition
When the Carcinoid tumor has metastasize so the products enter the systemic ciruclation. Sx: Flushing, diarrhea, colicky abd pain bronchospasm, sweating.
Term
What is the most impt feature of carcinoid tumor?
Definition
Where it is located! Anything above the ligament of trietz or below colon (+appendix) are better Px. Bt ligament of trietz & rectum, they may grow large, X, be aggressive or mets.
Term
Syaptophysin, chrmogranin A
Definition
Carcinoid
Term
If you have a tumor in appendix what is the most likely cause?
Definition
Carcinoid
Term
What can cause pseudomyxoma peritoneii?
Definition
Mucinous cystadenocarcinoma in the appendix
Term
If you see a 65yo w X small polyps in the L colon what is the most likely cause?
Definition
Hyperpastic Polps of the colon.
Term
Serrated surface archietecture w/ mature goblet & absorptive cells
Definition
Hyperplastic polyp
Term
Pulmonary AVM, age and what dz?
Definition
<5yo w Juvenile Type harmartomatous polyp
Term
3yo w a polyp causing rectal bleeding/proplase
Definition
Juvenile type Harmartomatous polyp
Term
Which non neoplastic polyp of the colon has cystically dilated gland filled w mucin & inflamm debris?
Definition
Juvenile type
Term
Which non neoplastic polyp of the colon has large polyp w a lobulated contour and Arborhizing archituecture?
Definition
Peutz Jughers
Term
PTEN
Definition
Cowden s/o or Bannayan Rubulacaba Riley s/o
Term
Pt w marcocephaly, benign skin tumors & colon polpys has what? Inc risk of what?
Definition
Cowden s/o. Inc risk of breast CA, endomeatrial CA, follicular thyroid CA. NOT inc risk of GI CA!
Term
Pt has colon polpys and mental deficiences, what do they have?
Definition
Bannayan-Rubulcaba-Riley s/o
Term
>50 you pt w GI polpys. ON PE you also see splitting and atrophy of the nails, hair loss, and hyper/hypo pigmentation of the skin; what do they have?
Definition
Cronkite-Canada s/o. 50% fatal. They might also have diarrhea, weakness, abd pain, wt loss.
Term
What type of colonic adenoma can secrete lg amt of protein & K?
Definition
Villous adenoma
Term
Does the architecture types of colonic adenoma give any Px info?
Definition
Not really, just the assoc w size. The larger the adenoma (usu villous) the more likley you will get colon CA.
Term
Do intramucosal adenocarcinoma spread?
Definition
Not really, they will just invade further into the wall. There are no lymphatic channels so not likley to spread far.
Term
what is the MC malignancy of the GI tract?
Definition
Colon adenocarcinoma
Term
Why are colonic adenoCA very firm?
Definition
They have a strong desmoplastic response when they invade into intestinal wall. IF they produce mucin that is a bad px
Term
What is MALToma assoc w?
Definition
EBV and immuno compromised.
Term
APC (MC) or MUTYH
Definition
FAP
Term
What s/o iss assoc with prophlatic colectomy bc there is a 100% chance of colon CA?
Definition
FAP
Term
FAP+tumors of skull/long bones, epidermal cysts, desmoid tumors, thryoid tumors, dental abn?
Definition
Garnder s/o
Term
FAP + Medulloblastoma (MC) or gliobastoma
Definition

Turcot s/o

Medulloblastoma assoc w FAP mutation

Glioblastoma assoc w DNA repiar gene mutations

Term
A 40 year old is dx w colon CA; but they have no polps and its in R colon.
Definition
HNPCC
Term
MSH1 and MLH1
Definition
HNPCC
Term
What is the MC site for colonic adenoCA
Definition
Term
There are two types of hereditary polyps in the GI tract that have an AR/AD assoc? which ones are they?
Definition
AD Cowden s/o, Bannayan-Rubulcaba-Riley, AFP
Term
What polyp dz is mostly in the L colon?
Mostly in the rectum?
Mostly in the small intestine?
Definition
L colon= Hyperplastic polyps of the colon
Rectum= Juvenile type harmartomatous
Small intestine= Puetz Jughers
Term
Salt and pepper chromatin
Definition
Carcinoid tumor
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