Term
| What are the general functions of cartilage? |
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Definition
Specialized CT Avascular Firm consistency Able to bear mechanical stresses w/o distortion Shock absorber Support soft tissues Facilitate bone movements sliding area for joints Development/growth of long bones 3 types: hyaline, elastic, fibrocartilage |
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Term
| What are the characteristics and function of Hyaline cartilage? |
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Definition
The most common cartilage Funtion: - temporary skeleton in embryo - replaced by bone
- responsible for long bone growth
- support soft tissues
- participates in joint structure (articular cartilage)
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Term
| What are some locations of Hyaline cartilage? |
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Definition
skeleton of fetus epiphyseal plate of growing bones walls of larger respiratory passages (nose, larynx, trachea, bronchi) articular surfaces of movable joints costal cartilages |
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Term
| What are the characteristics of the extracellular matrix of cartilage? |
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Definition
Contains mainly types II collagen rich in hydroxylysine (which is basophilic) also contains type 9, 10, and 11 collagen Territorial Matrix: immediately around cell, rich in GAGs, intense basophilia Interterritorial Matrix: between cells, more balanced ratio of GAG and collagen |
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Term
| What are the characterisitics of the ground substance of cartilage extracellular matrix? |
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Definition
GAGs: chondroitin 4 sulfate, chondroitin 6 sulfate, keratan sulfate, hyaluronic acid Proteoglycans: Aggrecan (cart-specific PG) Proteoglycan aggregates Glycoprotein: Chondronectin, Fibronectin Hydrophilic: matrix binds water (neg charges on GAGS), shock absorber, cushioning |
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Term
True/False Articular cartilage does not contain a perichondrium |
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Definition
True Neither does fibrocartilage |
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Term
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Definition
Layers of dense connective tissue that surrounds cartilage Contains vascular supply - nutrients diffuse thru matrix to reach cell Contains fibroblasts (which sythesize dense CT) and progenitor cells ( from mesenchyme) that will form chondroblasts |
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Term
| WHat are the characteristics of fibrocartilage? |
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Definition
characteristics intermediate between dense CT and hyaline cartilage Develops between dense CT Composition: chondrocyte cells, mostly type I collagen (some type II), ground sub. same as hyaline, collagen fibers form irregular bundles b/t chondrocytes - are aligned parallel to stresses Location: vertebral disks, pubic symphysis, some bony attachments (ligaments, tendons), components of some diarthroses (knee glenoid fossa, acetabulum, articular disk of clavicle and mandible) |
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