Term
| True/False: Cartilage is a type of bone tissue |
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Definition
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Term
| What are the types of cartilage tissue? |
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Definition
hyaline
elastic
fibro-cartilage
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Term
| Describe the differences between hyaline, elastic, and fibro cartilage |
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Definition
Hyaline= type II collagen
Elastic= type II collagen and elastic fiber
Fibro= Type I collagen |
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Term
| What type of cartilage is generally found in joints? |
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Definition
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Term
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Definition
| Cells in cartilage that produce matrix and fibers |
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Term
| What is the fate of chondroblasts? |
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Definition
| Eventually become entrapped in lacunae. Once entrapped, they become chondrocytes |
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Term
| What is a isogenous nest? |
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Definition
| Chondrocytes that are grouped together (2-6) |
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Term
| What is the matrix surrounding chondrocytes called? |
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Definition
Territorial matrix- contain GAG> collagen
Inter-territorial - collagen> GAG |
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Term
| What is the perichondrium? What is its role? |
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Definition
Dense irregular CT arise from mesenchymal cells differentiating into fibroblasts.
Supplied by blood vessels and nerves-->growth and repair |
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Term
| What's the difference between elastic and hyaline? |
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Definition
elastic has more elastic fibers.
Elastic does not calcify
Elastic few isogenic clusters |
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Term
| Where is fibro-cartilage found? |
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Definition
| Intervertebral disk, junction btwn muscle tendon+bone |
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Term
| Which cartilage does not have perichondrium? |
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Definition
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Term
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Definition
Chondrocytes arise from fibroblasts
Chondrocytes arranged in parallel rows
Bundles of collagen I |
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Term
| True/False: Fibrocartilage does not have a perichondrium |
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Definition
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Term
| True/False: Elastic cartilage does not have a perichondrium |
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Definition
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Term
| True/False: Hyaline cartilage does not have a perichondrium |
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Definition
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Term
| Which types of cartilage have collagen II? |
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Definition
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Term
| Whcih types of cartilage have collagen I? |
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Definition
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Term
| What is the outer surface of bone covered in? |
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Definition
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Term
| What is the layer lining the inner cavity of bone? |
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Definition
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Term
| What cell types constitute to bone? |
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Definition
| Osteoprogenitor cells, osteoclasts, osteoblast |
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Term
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Definition
| cells that produce the ECM of bone tissue |
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Term
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Definition
| Cells that digest bone tissue |
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Term
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Definition
| inactive osteoblasts calcified |
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Term
| What constituents make up the ground tissue of bone? |
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Definition
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Term
| Where are osteoprogenitor cells found? |
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Definition
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Term
| What are canaliculi? Where are they found |
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Definition
| Canuliculi are tiny channels that connect osteocytes together. |
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Term
| Which type of bone cell is multi-nucleated? |
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Definition
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Term
| What is the Howship's Lacuna? |
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Definition
| regions near osteoclast where bone digestion is occuring (usually pale region) |
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Term
| Describe how intra-membranous bone is formed |
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Definition
Mesenchymal cells-->Osteoblasts of trabeculae-->osteocytes connected by canaliculi
Peripheral mesenchyme-->fibroblasts-->form CT (aka peristomium/endosteum)-- |
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Term
| Describe the trabeculae of intramembranous bone near the surface and near the center of the bone |
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Definition
trabeculae near surface = concentric layers= compact bone
trabeculae near interior = random arrangement= spongy bone
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Term
| What are the hollow spaces of spongy bone called? |
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Definition
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Term
| How is spongy bone formed? |
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Definition
Irregularly branched trabeculae leave small spaces-->eventualyl fileld with marrow
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Term
| Whats the difference between yellow marrow and red marrow? |
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Definition
Red marrow has more hematopoietic cells than fat
Yellow marrow has more fat than hematopoietic cells |
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Term
| Describe endo-chondral bone ossification |
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Definition
- Cartilage bone model is formed
- Vascularization of diaphysis cartilage
- Chondroblasts and perichondrium give rise to osteoblasts
- Osteoblasts lay done bony matrix-->bony collar
- Bony collar prevent diffusion leading to chondrocyte death
- Osteoclasts digest calcified matrix and form periosteal buds
- Periosteal buds allow infiltration of nerves, vessels, hematopoietic and osteoprogenitor cells into bone center
- Osteoprogenitor cells derive more osteoblasts interiorly. Lays done calcified matrix
- Eventually osteoclasts absorb bone matrix and form marrow space
- Secondary ossification ctrs form at epiphysis
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Term
| Where does the periosteal bud arise from? |
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Definition
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Term
| Describe the layers of compact bone |
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Definition
Periosteum-->outercircumferential-->inner circumferential (lines marrow)-->Haversian canals hosue blood vessels
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Term
| What are the two canal systems in compact bone? |
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Definition
| Haversian canal (vertical) and Volkman Canal (horizontal) |
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Term
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Definition
Endro-chondral and intramembranous methods
- Injured blood vessels in bone form bloodclot in fracture
- Osteocytes, periosteum endosteum undergo avascular necrosis
- Bloodclot is infiltrated by vessels from periosteum
- Vessels contain osteoprogenitor cells
- Osteoprogenitors derive osteoblast and chondroblast
- Blood clot replaced by cartilage or bone
- Callus replaced by secondary bone
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