Term
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Definition
| a hetoregenous group of diseases of the myocardium associated w/mechanical and/or electrical dysfunction that usually (but not invariability) exhibit inappropriate ventricular hyperthrophy or dilatation and are due to a variety of causes that frequently are genetic. Cardiomyopathies either are confined to the heart or part of generalized systemic disorders often leading to cardiovascular death or progressive heart failure-related disability |
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Term
Classification of cardiomyopathies
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Definition
- Primary-classified as genetic, mixed, or acquired
- Secondary-is a heart muscle disease in the presence of multisystem disorder
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Term
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Definition
- Hypertrophic cardiomyopathy (HCM) - unexplained left ventricular hypertrophy w/ disproportionate thickening of the ventricular septum, abnormal diastole filling, cardiac arrhythmias, and intermittent left ventricular out flow obstruction. Other complications include A-fib, stroke, & heart failure. Autosomal dominant heart disease- mutations in the genes encoding proteins of the cardiac sarcomere
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Term
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Definition
- Hypertrophic cardiomyopathy (HCM) - unexplained left ventricular hypertrophy w/ disproportionate thickening of the ventricular septum, abnormal diastole filling, cardiac arrhythmias, and intermittent left ventricular out flow obstruction. Other complications include A-fib, stroke, & heart failure. Autosomal dominant heart disease- mutations in the genes encoding proteins of the cardiac sarcomere (muscle fibers)
- Abnormalities- reduce ventricular chamber size; poor compliance w/reduced stroke volume that results from impaired diastolic filling; and, in about 25% of cases, dynamic obstruction of left ventricular outflow
- Clinical manisfestation: dyspnea, chest pain during exertion, or exercise intolerance: causing massive hyperthrophy, high left ventricular chamber pressure, and potentially abnormal intramural arteries, focal myocardial ischemia often develops even in the absence of CAD; anginal pain is common
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Definition
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