Term
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Definition
Catalyzes formation of plasmin from plasminogen bound to fibrin
Breaks down clots |
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Term
| Hemostatics- antihemophiliac factor recominant |
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Definition
Functions as cofactor 9a which converts X to Xa and coagulation cascade
May cause factor 8 inhibitory disorder (hemophilia) |
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Term
| Treatments for cardiac arrhythmias |
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Definition
Class 1B- lidocaine- inhibits Na channel-->decrease sodium current-->decrease pacemaker activity; AE- neurological
Class 2- beta blockers- propanalol- inhibits cardiac b1/2 adrenoreceptors-->prolonged effective refractory period (TP-interval)
Class 3- amiodarone inhibit alpha and beta adrenergic-R- prolong TP segment- **CATEGORY D
Class 4- Verapamil- block calcium channel |
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Term
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Definition
Statin- lovastatin- competitive inhibition of HMG-CoA reductase in hepatocytes
Inhibit rate limiting enzyme in production of chol. and isoprenoids
Increase HDL, decrease LDL, decrease protein prenylation
***CATEGORY X |
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Term
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Definition
Diuretics- loop or high celling- furosemide- inhibition of NKCC2 in TAL of loop of Henle in neophron
Positive ionotropics- Digoxin- inhibit Na/K ATPase in cardiac myofibril- increases intracellular calcium- decrease QT interval-->James bond |
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Term
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Definition
| Nitroglycerin- NO-->increase cGMP-->dephos. myosin light chain and decrease intracellular calcium-->relax smooth muscle Verapamil- block L-type Ca channels-->reduce transmembrane Ca current-->longer relaxation-->vasodilation |
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Term
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Definition
a2 adrenoreceptors
Decreased CO, due to decreased HR, decreased capacitance of vessels, and decreased PVR/TPR |
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Term
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Definition
- Diuretic
- Inhibits Na/Ka co-transporter
- Acts in DCT (distil convoluted tubule) in nephron
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Term
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Definition
- Partial alpha-2 agonist
- Acts on medulla (primary) and arterioles
- Decreases CO
- *Skin reactions due to patch
- *Hypertensive crisis- WEAN patients off it
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Term
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Definition
- Vascular smooth relaxation
- Activates guanylyl cylase-->increases [cGMP]-->NO release
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Term
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Definition
Propanolol
- Hypertension and anti-arrythmia drug
- B1 and B2 adrenoreceptor agonist of heart and kidney
- Decreases CO
- Blocks renin production
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Term
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Definition
Verapamil
- Blocks L-type Ca channel in cardiac and smooth muscle cel mem
- Decrease contractility
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