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Cardiotoxicity
Mechanisms of Vasculotoxicity
22
Architecture
7th Grade
02/09/2013

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Term
vascular injury and vasculitis
Definition
vasculotoxicity
Term
conduct blood to tissues; transport oxygen, nutrients, wastes and drugs
Definition
Vasculature
Term
maintenance of permeability barrier; source of anticoagulant/antithrombotic molecules
Definition
endothelial cell
Term
prostacyclin, thrombomodulin, plasminogen activator, heparin-like molecules
Definition
anti-coagulant/antithrombotic molecules
Term
von Willebrand factor, tissue factor, PA inhibitor
Definition
prothrombotic molecules
Term
vasoconstrictors, vasodilators
Definition
modulation of blood flow and vascular reactivity
Term
endothelin, ACE
Definition
vasoconstrictors
Term
nitric oxide, prostacyclin
Definition
vasodilators
Term
other functions of endothelial cells
Definition
modulation of blood flow, regulation of inflammation/immunity, regulation of cell growth; oxidation of LDL
Term
growth stimulators
Definition
PDGF, CSF, FGF
Term
growth inhibitors
Definition
heparin, TGF-B
Term
release of growth factors and cytokines; migration and proliferation
Definition
vascular smooth muscle functions
Term
mechanisms of drug-induced vascular injury
Definition
biomechanical injury; toxicity following direct pharmacological and/or chemical perturbation; injury via immune-mediated mechanisms
Term
affecting mainly large- and medium- sized arteries
Definition
vasodilators
Term
vasodilators
Definition
Methylxanthinese (caffeine, theophylline); potassium channel activators (minoxidil, diazoxide)
Term
potassium channel activators
Definition
minoxidil, diazoxide
Term
affecting mainly small arteries andarterioles
Definition
vasoconstrictors
Term
vasoconstrictors
Definition
vasopressin, angiotensin II, epinephrine, phenylepinephrine, methoxamine
Term
drug induced vascular injury
Definition
vasodilators, vasoconstrictors, exacerbation of pre-existing pathology (atherosclerosis)
Term
exacerbation of pre-existing pathology (atherosclerosis)
Definition
cholesterol and oxygenated derivatives; organophosphates; cadmium, arsenics, mercury
Term
a heterogenous group of disorders characterized by inflammatory destruction of both arteries and veins
Definition
drug-induced vasculitis
Term
drug-induced vasculitis
Definition
propylthiouracil, ciprofloxacin
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