Term
vascular injury and vasculitis |
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Definition
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Term
conduct blood to tissues; transport oxygen, nutrients, wastes and drugs |
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Definition
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Term
maintenance of permeability barrier; source of anticoagulant/antithrombotic molecules |
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Definition
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Term
prostacyclin, thrombomodulin, plasminogen activator, heparin-like molecules |
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Definition
anti-coagulant/antithrombotic molecules |
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Term
von Willebrand factor, tissue factor, PA inhibitor |
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Definition
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Term
vasoconstrictors, vasodilators |
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Definition
modulation of blood flow and vascular reactivity |
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Term
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Definition
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Term
nitric oxide, prostacyclin |
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Definition
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Term
other functions of endothelial cells |
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Definition
modulation of blood flow, regulation of inflammation/immunity, regulation of cell growth; oxidation of LDL |
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Term
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Definition
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Term
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Definition
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Term
release of growth factors and cytokines; migration and proliferation |
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Definition
vascular smooth muscle functions |
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Term
mechanisms of drug-induced vascular injury |
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Definition
biomechanical injury; toxicity following direct pharmacological and/or chemical perturbation; injury via immune-mediated mechanisms |
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Term
affecting mainly large- and medium- sized arteries |
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Definition
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Term
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Definition
Methylxanthinese (caffeine, theophylline); potassium channel activators (minoxidil, diazoxide) |
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Term
potassium channel activators |
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Definition
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Term
affecting mainly small arteries andarterioles |
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Definition
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Term
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Definition
vasopressin, angiotensin II, epinephrine, phenylepinephrine, methoxamine |
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Term
drug induced vascular injury |
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Definition
vasodilators, vasoconstrictors, exacerbation of pre-existing pathology (atherosclerosis) |
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Term
exacerbation of pre-existing pathology (atherosclerosis) |
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Definition
cholesterol and oxygenated derivatives; organophosphates; cadmium, arsenics, mercury |
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Term
a heterogenous group of disorders characterized by inflammatory destruction of both arteries and veins |
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Definition
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Term
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Definition
propylthiouracil, ciprofloxacin |
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