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Cardio Pharmacology
drugs
10
Pharmacology
Professional
08/20/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Atropine Sulfate
Definition

Classification: Parasympatholytic, Anticholinergic, Vagolytic

Mechanism: Via direct vagolytic action enhances SA node Automaticity,  AV node Conduction

used for: hemodynamically significant bradyarrhythmias and asystole

to speed up heart

Dose: .5mg alive,  1 mg dead  up to 3mg

Term
Epinephrine
Definition

Classification:  Vasopressor, vasoconstrictor

 

Mechanism: improves coronary and cerebral perfusion, Peripheral vasoconstrictor, produces favorable redistribution of blood flow during cardiac arrest

 

Dose: 1 mg every 3-5 min during CPR

Term
Lidocaine
Definition

Classification:  class 1B antiarrhythmic/ Ventricular antiarhythmic

Mechanism:  Decreases automaticity thereby supressing ventricular arrhythmias,  elevates the V-fib threshold,  mild sodium blockage, reduces the slope of phase four diastolic repolarization

Dose:  initial bolus 1-1.5 mg/kg drip

2nd bolus of .5 mg/kg after ten minutes

3rd .5 mg/kg max dose of 3mg

start drip of 2-4 mg/min

 

Term
Amiodarone
Definition

Classification:  Atrial  and Ventricular antiarrhythmic

Mechanisms:  Effects Sodium, potassium and Calcium channels, alpha and beta adrenergic blockage, coronary and peripheral vasodilation, lengthens refractory period in cardiac tissue

Dose:  300 mg IV Bolus if dying

otherwise 150mg over 10 min(may be repeated as needed)

max dose 2gm/day

Term
Procainamide(Pronestyl)
Definition

Type: Ventricular Antiarrhythmic

Mechanism:  supresses ventricular ectopy, slows intraventricular conduction

extends phase four of action potential

Dose: 20-30 mg/min up to 17mg/kg

maintenance rate is 1-4mg/min

Term
Magnesium Sulfate
Definition

Type: Ventricular antiarrhythmic

Mechanisms:  reduction in post infarction ventricular arrhythmias, precipitate refractory v-fib, hypomagnesemia can lead to cardiac arrhythmias and sudden cardiac death

Dose:  V-fib or V-tach-1-2gm in 100ml NS over 1-2 min

Post MI:  loading dose 1-2mg in 100 ml over 5-60 min

Term
Adenosine
Definition

Type: Supraventricular antiarrhythmic

Mechanism: bring heart back to normal rhythm,not useful for all types of irregular heartbeats, slows AV node conduction, terminated PSVT,  May be used to test the heart for coronary artery disease, has a half-life of 5 seconds, not a fix for A-fib or A-flutter but a great diagnostic tool

Dose: 6mg over 1-3 sec followed by 20ml flush

12mg over 1-3 sec

12mg over 1-3 sec

Term
Verapamil (Isoptin)
Definition

Type: Supraventricular anti-arrhythmic, Calcium channel blocker

Mechanisms:  Calcium channel Blocker,  Relaxs blood vessels,  Vasodilatoreffects due to blockade of Ca channels and alpha receptors, decreases inotropy

Dose: initial 2.5 - 5.0 mg IV over 2 min

repeat dose 5 -10 mg 15-30 min until max of 20mg

Term
Diltiazem (cardizem)
Definition

Type: Supraventricular Antiarrhythmic, Ca channel blocker

Mechanism: fewer hemodynamic effects than verapamil, slows conduction and prolongs refractoriness in AV node

Dose: .25 mg/kg over 2 min

followed by maintenance infusion of 5-15mg titrated to desired heart rate

Term
Procardia (Niphedipine)
Definition

Type: Ca++ channel blocker

Mechanism: Dilates main coronary arteries and arterioles in both normal and ischemic areas of the heart, inhibits spasms of the coronary arteries

Dose: 10-20mg TID to control angina

Max 180mg/day

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