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Cardio-Pharm
Anti-arrhythmics
32
Pharmacology
Graduate
10/07/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Side effects of Class 1a Anti-arrhythmics
Definition

Refractory Heterogeneity-> Torsades de pointes-> Recurrent lightheadedness-Quinidine Synecopy

Vagolytic

Quinidine- Increases Digitalis levels Procainamide- Transient Lupus Symptoms

Term
Side effects of Class 1b Anti-arrhythmics
Definition

CNS Side Effects: Tremor, Nausea, Light-headedness

B-blockers increase lidocaine clearance

Term
Side effects of Class 1c Anti-arrhythmics
Definition
Proarrhythmic
Term
Side effects of Class 2 Anti-arrhythmics
Definition
Hypotension, Bradycardia Increases Clearance of Lidocaine Never with Ca Channel Blockers
Term
Side effects of Class 3 Anti-arrhythmics
Definition
Amiodarone- Pulmonary Fibrosis, Hypo/Hyperthyroid, Decreased SA/AV/Inotropy/Tension, Increased Liver enzymes, Tremor/Ataxia/Headaches/Peripheral Neuropathy, Corneal Microdeposits/ Testicular Dysfunction/Skin Discoloration Bretylium- Trans Increase, Perminant Decrease in Catecholamines
Term
Side effects of Class 4 Anti-arrhythmics
Definition
Hypotension/Bradycardia, Never with B-blockers
Term
Limitations to Adenosine Use
Definition

Short Half-Life

Caffeine/Theophylline Block

Term
Indication for Class 1a Anti-Arrhythmics
Definition
Quinidine- All esp A.Fib/A.Flut Procainamide- Ventricular Arrhythmias after MI Disopyramide- Venticular arrhythmias PSVT
Term
Indication for Class 1b Anti-Arrhythmics
Definition

Ventricular Arrhythmias,

Digitalis Induced Arrythmias

Term
Indication for Class 1c Anti-Arrhythmics
Definition
Paroxysomal Supraventricular Tachycardia Ventricular Tachycardia A.Fib/A.Flut
Term
Indication for Class 2 Anti-Arrhythmics
Definition

Stabilize Ventrical in A.Fib/A.Flut Ventricular Re-Entry Arrhythias PAC, PVC, PSVT

Ischemia-Related Ventricular Tachycardia

Term
Indication for Class 3 Anti-Arrhythmics
Definition

Amio- A.Fib/A.Flut

Ventricular Tachycardia

Bypass-Tract(Kent) PSVT

Term
Indication for Class 4 Anti-Arrhythmics
Definition

Protect Ventrical in A.Fib/A.Flut

Multifocal Atrial Tachycardia

PSVT

Term
Indication for Adenosine
Definition
Paroxisomal Supraventrical Tachycardia
Term
Mechanism of Class 1a Anti-arrhythmics
Definition
Decrease Na Conduction
Mild Decrease in K conduction
Term
Mechanism of Class 1b Anti-arrhythmics
Definition
Decrease Na conduction in Depolarized and Active Heart Tissue, but not Resting Tissue
Term
Mechanism of Class 1c Anti-Arrhythmics
Definition

Na: Block Fast Na Conduction

AV: Decrease condution ->

Widen QRS

Prolong AP

Effective on His-Purkinje System

Term
Mechanism of Class 2 Anti-arrhythmics
Definition
Decrease AV Node conduction
Decrease SA Node Firing
Decrease K Conduction
Term
Mechanism of Class 3 Anti-arrhythmics
Definition
Amodarone- 1,2,3
Ibutilide- 3
Sotalol- 2,3
Term
Mechanism of Class 4 Anti-Arrhythmics
Definition

Ca Channel Block

Decrease AV/SA Node Conduction

Term
Mechanism of Adenosine
Definition
Increase K Conduction
Decrease Ca Conduction
Effective on the AV Node
Term
Class 1a Anti-Arrhythmics
Definition
Quinidine, Procainamide, Disopyramide
Term
Class 1b Anti-Arrhythmics
Definition

Lidocaine

Tocainide

Mexiletine

Phenytoin

Term
Class 1c Anti-Arrhythmics
Definition

Flecainide

Moricizine

Propafenone

Term
Class 2 Anti-Arrhythmics
Definition
Sotalol, Propanolol, Acebutylol
Term
Class 3 Anti-Arrhythmics
Definition
Amiodarone, Sotalol, Ibutilide, Bretylium
Term
Class 4 Anti-Arrhythmics
Definition
Verapimil, Diltiazem
Term
Treatment of Paroxysomal Supraventricular Tachycardia
Definition

Acute: Adenosine, Verapamil, Diltiazem

Chronic: Oral Verapamil, Diltiazem, or Class 2

Term
Treatment of Atrial Fribillation
Definition

Rate: Class 2 or Class 4

Rhythm: Class 1c of 3

Term
Treatment of Ventricular Arrhythmias
Definition
IV Lidocaine, Flecainide, Amiodarone
Term
What should you be aware of when using lidocaine  with a patient on Beta-blockers
Definition
B-blockers decrease the clearance of lidocaine
Term
If a patient is in an arrythmic beat has aslo been taking Digoxin what anti-arrythmic drug is indicated and which anti-arrythmic is contra-indicated?
Definition

Indicated: Class 1b

Contraindicated: Quinidine

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