Term
Mechanism of Aliskiren?
Major limitation? |
|
Definition
Mechanism: Direct Renin Inhibitor
2.5% Bioactivity |
|
|
Term
| Indications For ACE Inhibitor Use |
|
Definition
| HPTN, Post MI, Diabetic Nephropathy, CHF |
|
|
Term
| Adverse Effects of ACE Inhibitor Use |
|
Definition
Bradykinin: Cough, Rash
Hyperkalemia, Hypotension
Renal Failure, Angioedema
Teratogen, Neutropenia |
|
|
Term
| Contraindications For ACE Inhibitor Use |
|
Definition
Hyperkalemia, Hypotension
Renal Failure, Pregnancy
Aortic Stenosis, Renal Stenosis,
Obstructive Cardiomyopathy |
|
|
Term
| When is ACE Inhibitor Therapy Ineffective |
|
Definition
|
|
Term
| Classes of ACE Inhibitors |
|
Definition
| 1:Captopril (Active, Metabolized) 2:Enalopril (Prodrugs) 3:Lisinopril (Active, Not Metabolized) |
|
|
Term
| Why is are ACE Inhibitors Effective in Patients with IHD |
|
Definition
|
|
Term
| Hemodynamic effects of ACE Inhibitors |
|
Definition
| Decrease both Preload and Afterload |
|
|
Term
What are the major Angiotensin Receptor Inhibitors
When are they indicated? |
|
Definition
Losartan, Valsartan
ACE Inhibitor-induced Cough and Rash is Unreasonable |
|
|
Term
| Angiotensin Receptor Inhibitors |
|
Definition
|
|
Term
|
Definition
| Spironolactone, Elperenone |
|
|
Term
| Mechanism of Spironolactone |
|
Definition
Increased NO
Decrease Fibrosis
Decreased Vasoconstriction
Diuresis |
|
|
