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Details

Cardio-Path
Ischmic Heart Disease
16
Pathology
Graduate
10/09/2010

Additional Pathology Flashcards

 


 

Cards

Term
What type of MI is more likely to involve multiple coronary arteries
Definition
Subendocardial
Term
Pathogenesis of MI
Definition
Plaque Disruption-> Platelet Adhesion/Aggregation-> Thromboxane A2-> Vasospasm and Clotting Activation-> Thrombus and Occlussion
Term
MI Micro observations at: 1/2-4 hrs, 4-12 hrs, 12-24 hrs, 1-2 days, 3-7 days, 7-10 days, 10-14 days, 2-8 wks
Definition

1/2-4: Wavy Boarder fibers

4-12: Hemorage, Edema, Necrosis

12-24: Pyknosis, Eosinophilia

1-3: Max PMNs 

3-7: Boarder Phagocytosis

7-10: Early Granulation Tissue

10-14: Late Granulation

2-8 wks: Collagen Deposition

Term
What type of tissue will stain with TTC
Definition
Normal tissue, Abnormal is unstained
Term
Gross MI observations at: 1/2-4 hrs, 4-12 hrs, 12-24 hrs, 1-2 days, 3-7 days, 7-10 days, 10-14 days, 2-8 wks
Definition

1/2-4: Nothing

4-12: Mottling

12-24: Mottling Red-Blue

1-3: Yellow-Tan

3-7: Hyperemic Boarder

7-10: Depressed, Red-Tan Boarder

10-14: Depressed, Red-Brown Boarder

2-8 Wks: Grey White Scar

Term
How do you indetify reperfusion injury microscopically
Definition
Contraction Band Necrosis
Term
Possible complications of Ventricular rupture and when is it most likely to happen
Definition

Papillary Muscle: Mitral Regurg

Septa: Left-right Shunt

Free wall: Hemopericardium

Mostly likely 3-7 days post MI

Term
How can an MI make you more suseptible to thrombosis
Definition

Area of MI generates more blood stasis

MI generates Endocardial damage

Term
Where is the heart vulnerable to Aneurysm
Definition
Anteroseptal
Term
What is the difference between expansion and extension of an area of infarcted myocardium
Definition

Expansion: weakening and stretching of fibers

Extension: Additional infarction enlarging the leasion

Term
Where does the endothelium derive its oxigen from
Definition
diffusion from the lumen
Term
Describe the characteristics of a person with the worst prognosis post MI
Definition
Elder diabetic women who had an MI before
Term
Why is ischemia worse than hypoxemia
Definition
Toxic metabolites cannot be cleared in ischemia
Term
What area of the heart is the least perfused?
Definition
Subendocardium
Term
What is the most common mechanism of sudden cardiac death?
Definition
Lethal Arrhythmia
Term
What is the most common morpholgy of the heart in a patient that died of a lethal arrhythmia?
Definition
Hypertrophied
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