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Cardio lecture 4
a
70
Nursing
Undergraduate 2
11/26/2011

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Term
4.5-5.5 million/mm2
Definition
normal adult level of RBC's
Term
hemoglobin
Definition
iron compound in RBC's that carry O2
Term
13.5-18
12-16
Definition
normal hemoglobin for
males _____
females ____
Term
hematocrit
Definition
percentage of blood volume that is composed of RBC's
Term
40-54%
38-47%
Definition
normal hematocrit range for
males ______
females _____
Term
120 days
Definition
lifespan of RBC's
Term
bone marrow and spleen
Definition
hemolysis(destruction) of RBC's occurs in the __(2)__
Term
bilirubin
Definition
hemolysis (destruction) of RBC's results in increased _____ to be processed in the body
Term
jaundice
Definition
____ results from increased hemolysis or impaired liver or gallbladder function
Term
5,000 - 10,000
Definition
normal adult levels of WBCs
Term
neutrophils
Definition
WBC's whose primary function is phagocytosis of bacteria
Term
bands or stab cells
Definition
immature neutrophils are called _____
Term
lymphocytes
Definition
WBC that primarily increases with acute viral infections and transplant rejections
Term
monocytes
Definition
WBC that is a potent phagocytic cell
- mature into macrophages to clean wounds prior to healing
Term
eosinophils
Definition
WBC that is primarily involved in allergic Rx and parasitic infection
Term
basophils
Definition
WBC that has the same action as eosinophils
Term
basophils
Definition
WBC that causes inflammation and capillary leak to move WBC to injured site
Term
150,000 - 400,000
Definition
normal level of platelets in blood
Term
spleen
Definition
organ that filters blood by destruction of old or damaged RBCs and platelets
Term
spleen
Definition
site of WBC production
Term
spleen
Definition
filters blood and removes bacteria, viruses, and debri
Term
spleen
Definition
stores blood and the breakdown products of RBCs for future use
Term
liver
Definition
processes RBC and excretes bilirubin in bile
Term
liver
Definition
production site for most blood clotting factors
Term
murmurs
Definition
_____ may be present with anemia because decreased RBCs decreases the viscosity of the blood
Term
carbon monoxide
Definition
smoking is discouraged with anemia because ____ binds to RBC's instead of oxygen and exacerbates hypoxia
Term
iron, folic acid, B12
Definition
defiency of any of these three can cause anemia
Term
duodenum
Definition
surguries and disease of the ____ can lead to iron deficiancy
Term
glossitis
Definition
inflammation of the tongue that can be present with all types of anemia
Term
cheilosis
Definition
inflammation of the lips that can be present with all types of anemia
Term
B12 deficiency
Definition
type of anemia that can cause weakness, paresthesia, and confusion
Term
Schilling test
Definition
test used to determine if the body properly absorbes B12 (Pernicious anemia)
Term
low oxygen
Definition
in sickle cell anemia, _____ causes RBC's to become stiff and sickle shape
Term
sickle cell anemia
Definition
disease which causes RBC's to be unable to pass easily through capillaries or small vessels causing vascular obstruction
Term
spleen - anemia
Definition
in sickle cell disease, the sickled RBC's are hemolysised by the _____ which leads to _____
Term
oxygenation
Definition
initially, the sickling of RBC's is reversible with ______, but eventually becomes irreversible due to cell membrane damage
Term
vasoocclusive phenomena - hemolysis
Definition
____ and ____ are the clinical hallmarks of sickle cell disease
Term
jaundice
Definition
s/s of sickle cell anemia r/t to hemolyis of sickled RBC's
Term
pain
Definition
vasoocclusive crisis causes ___ in the abdmomen, long bones,hands and feet, joints
Term
hemophilia
Definition
clotting factor disorder in which prolonged coagulation causes persistant and severe bleeding
Term
males
Definition
gender most often effeted by hemophelia
Term
hemophelia A
Definition
type of hemophelia that results from a deficiency of Factor VIII
Term
hemophelia B
Definition
Christmas disease
- hemophelia that results from a deficiency of Factor IX
Term
von Willebrand's disease
Definition
hemophelia that is a result of protein deficiency and factor VIII
Term
polycythemia
Definition
condition of primarily excessive RBC's; however, WBC's and platelets can also increase
Term
chromosome mutation
Definition
primary polycythemia is caused by a ______ _____
Term
hypoxia
Definition
secondary polycythemia is caused by ______
Term
hypervolemia - hyperviscosity
Definition
the s/s of polycythemia are r/t to the ______ and _______
Term
phlebotomy
Definition
procedure used to treat polycythemia which involves removing excess blood
Term
chemotherapy
Definition
procedure use to treat polycythemia that inhibits bone marrow's production of RBC;s
Term
thrombocytopenia
Definition
low platelet count
Term
bleeding
Definition
thrombocytopenia casuses prolonged minor or sudden excessive ______
Term
immune thrombocytopenic purpura
Definition
disease that occurs when the immune system destroys circulating platelets
Term
nonimmune/secondary thrombocytopenia
Definition
disease caused by the destruction of platelets seconary to drugs, infection, malignancy
Term
splenectomy
Definition
last resort procedure done to treat thrombocytopenia by decreasing platelet destruction
Term
multiple myeloma
Definition
malignant disorder of the blood plasma cells in which the neoplastic cells infiltrate the bone marrow
Term
WBC, RBC, platelet production
Definition
multiple myeloma causes a decrease in ____(3)___
Term
bone destruction
Definition
with multiple myeloma, cancer of the bone marrow causes ____ _____
Term
2-5 years
Definition
multiple myeloma is rarely cured and death ussually occurs within _____
Term
leukemia
Definition
malignancy of WBC's in which bone marrow fills with dysfunctional WBC's
Term
leukemia
Definition
disease in which RBC's and platelets are crowded out of marrow causing anemia and bleeding
Term
splenomegaly, hepatomegaly, lymphadenopathy
Definition
Leukemic cells leave the bone marrow and move to the circulatory system and infiltrate other organs causing _(3)_
Term
malignant lymphoma
Definition
disease that originates in the lymphoid tissue and bone marrow resulting in proliferation of lymphocytes and progressive painless enlargement of the lymph nodes
Term
spleen - liver
Definition
in malignant lymphoma, the malignancy can spread along the lymphatic network infiltrate organs such as ____ and ____
Term
hodgkins lymphoma
Definition
highly curable disease of enlarged malignant lymph nodes
Term
neck - adjoining nodes
Definition
in Hodgkins disease, painless enlarged lymph nodes ussually start in the ____ and spread to _______
Term
Reed-Sternberg cells
Definition
malignant cells present only in Hodgkins lymphoma
Term
alcohol
Definition
with Hodgkins lymphoma, the ingestion of _____ can cause pain at diseased sites
Term
non-hodgkins lymphoma
Definition
disease of painless enlarged lymph nodes that are randomly spread throughout the body and spread unpredictably
Term
non-hodgkins lymphoma
Definition
lymphoma in which there are no Reed-Sternberg cells present
- poor prognosis
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