Term
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Definition
| Other: Good offset by increase in chol synth, use statin, can also interfere w/absorption of other oral drugs |
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Term
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Definition
| Other: More than just effects on decrease cholesterol (CAD): improve endothelial cell function, enhance plaque stability, reduce inflamm |
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Term
| Cholesterol Absorption Blockers |
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Definition
| Other: Bile acid binding resins inhib absorption of ezetimibe (use other or other w/a statin) |
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Term
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Definition
| Other: Using niacin + statin = increase in statin-induced myopathy. Uses sustaines-release niacin (Niaspan) |
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Term
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Definition
| Other: Fibrates + Statin = increased statin-induced myopathy (heart disease), LDL increase in some, use is combo but has same SE for myopathy as the niacin/statin combo, good @ decreasing TGs |
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Term
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Definition
Other: Tolerance = major problem thus use intermittently. Sildenafil and other ED drugs last longer b/c blockage of cGMP metabolism
In Stable angina = veins relax
In Variant angina = reverses spasms |
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Term
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Definition
| Other: use w/caution in people w/conduction disorders or obstructive lung disease, abrupt withdrawals can cause attacks or other ischemic symptoms (very dangerous rebound effect) |
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Term
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Definition
Other: careful in conduction issues and in combo w/B-blockers b/c can cause heart failure (VD, but can use dihydro + b-blockers), lots of drug interactions
Stable: decrease work
Variant: coronary A spasm |
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Term
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Definition
Other: efficacy and tolerability NOT change elderly and comorbid (preexisting) conditions (diabetes, heart fail)
ALMOST ALL PTS CAN TAKE SAFELY!!! (b-block have issues in diabetes and heart fail) |
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Term
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Definition
| Other: 5-8% show resistance to x-plate effects (have increase risk of SE's) |
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Term
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Definition
| Other: Clopidogrel = rapidly replacing ticlopidine b/c quicker onset and less neutropenia. Some people resistant to clopidogrel. |
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Term
| GP IIb/IIIa Receptor Inhibitor |
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Definition
| Other: best used prior to percutaneous coronary interventions than in unstable angina |
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Term
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Definition
Other: Resistance forms b/c of differences in concentrations of heparin-binding proteins in plasma or b/c accelerate clearance
Anti-coags have increased risk of bleeding than x-plates, don't use in pts w/bleeding disorders |
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Term
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Definition
| Other: overall more favorable long-term outcomes than heparin, limited data on cost effectiveness (enoxaparin: heparin may still cost less) |
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Term
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Definition
| Other: trials underway to determine efficacy in unstable angina and other ischemic syndromes |
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Term
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Definition
Other: less benefit in old or high BP post MI, more benefits in diabetes post MI
Life saving in acute MI, serious issues if not careful |
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Term
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Definition
| Other: Also in Unstable angina, pain relief is a primary goal in the setting of acute chest pain due to MI |
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Term
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Definition
Other: benefits clear in old, prior MI, congestive heart failure or other reduced ventricular function pts
HT: no benefic to combining ARB and ACEI in HT but happens alot |
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Term
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Definition
Other: lots vit K = less effective, liver disease increase effect
Heparin is too risky in the long term, and this doesn't x-coag in test tube like heparin does. |
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Term
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Definition
| Other: resistance to diuretic effect happens lots in HF pts, overcome w/higher dose or adding thiazide. Combo w/K-sparing diuretic (prevent K loss), action potentiated (increased) by renin-angiotensin inhibs (ACEI or ARB), also put on low sodium, high potassium diets, ONLY diuretic used for acute decomp, less effective than thiazide in hypertension, use in chronic renal failure w/high BP |
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Term
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Definition
| Other: combo w/K-sparing diuretic (prevent xs K loss), actions potentiated (increased) w/angiotensin inhib (ACEI or ARB), choice in hypertense w/out comorbid dx, not strong enough in hypertense w/chronic renal fail, second in heart fail to loop diuretics |
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Term
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Definition
Other: Aldosterone antagonists (also K sparing) block insertion of channel into membrane…the two are not the same
Use in heart fail w/high BP |
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Term
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Definition
| Other: why it's help still being worked out, use in people that don't response to other BP drugs (main use in hypertension, more SE's than other K sparing) |
|
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Term
| Renin Angiotensin Inhibitors (HF) |
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Definition
| Other: no benefit to combo ACEI w/ARB, combo w/diuretic |
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Term
| Direct Arterial Vasodilators |
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Definition
| Other: use w/inability to tolerate ACEI/AR or blacks |
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Term
|
Definition
| Other: lots interactions, K+ or digoxin x-ab's to tx OD (hard to use), clinical use decrease b/c cause arryth (b/c increase Ca inside myocardial cells) |
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Term
|
Definition
Other: Dobutamine continuous IV several days in severe clinical decomp, pharm tolerance limit efficacy in long term
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Term
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Definition
| Other: DRUG OF CHOICE in pts w/b-blockers that need inotropic support (like in decomp), chronic consistent therapy decrease survival |
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Term
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Definition
| Other: may be associated w/ risk of xs mortality and worsening of renal insufficiency |
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Term
|
Definition
| Other: decrease ventricular contractility, musc ant, decrease clinical use b/c causes aryths |
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Term
|
Definition
| Other: lidocaine MUST be parenterally (not oral), little effect on EKG |
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Term
|
Definition
| Other: prone to cause arryth, decrease ventricular contractility |
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Term
|
Definition
| Other: decrease sudden cardiac death post MI |
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Term
|
Definition
| Other: Amiodarone blocks alpha and beta receptors, Ca and Na channels. Ibutilide, dofetilide and azimilide for term A fib/flut |
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Term
|
Definition
| Other: on EKG look like B-blocker |
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Term
|
Definition
| Other: SHORT DURATION (acute), IV only |
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Term
|
Definition
| Other: Expensive and new/unproven |
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