Term
| Factor produced by both intrinsic and extrinsic pathways of coagulation? |
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Definition
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Term
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Definition
- Part of the final common pathway
- Facotr Xa + Ca++, and phospholipids + factor-V → forms prothrombin-activator-complex → converts pro-enzyme prothrombin (inactive) → thrombin (active enzyme) → thrombin clips fibrinogen → causes release of fibrin monomers → fibrin monomers polymerize → stabilize initial platelet plug
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Term
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Definition
- Factor XIII (inactive) + thrombin → Factor XIIIa (active)
- Factor XIIIa covalently cross-links adjacent fibrin monomers → causes formation of insoluble fibrin clot
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Term
| Goals of thromboemoblic therapy |
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Definition
Prevent thrombosis
Prevent thrombosis from embolization
Breakup thrombosis |
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Term
| General classes of agents for thromboembolic disease |
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Definition
- Anti-coagulant drugs
- Anti-platelet drugs
- Fibrinolytic (thrombolytic drugs)
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Term
Anti-coagulant drugs
General
Drugs w/in class |
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Definition
- These slow the clotting time + suppress coagulation
- Examples of drugs in this class:
-Heparin, LMW heparin, Fondaparinux
-Warfarin (for slow + prolonged + oral anti-coagulation)
-Direct thrombin inibitors (Lepirudin, bivalirudin, argatroban) |
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Term
| Direct thrombin inhibitors general |
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Definition
- Thought these would have fever SE than warfarin
- Have fewer drug-drug interactions than warfarin
- There is NO accurate testing for their affect on coagulation (cannot use PT or aPTT)
- These are oral medications
- BUT these have been reported to cause SEVERE bleeding and their use is being reconsidered b/c they are unable to be monitored
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Term
Drugs w/in antiplatelet drug class
Also provide MOA of each drug in this class |
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Definition
- These inhibit platelet adhesion + aggregation
Drugs within this class:
-Asprin: Inhibits TXA2
-Clopidogrel + Ticlopidine: Inhibit platelet ADP rec.
-Cilostazol: cAMP PDE inhibtor
-Abciximab, eptifibatide, tirofiban:
These block glyoprotein IIb/IIIa complex |
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Term
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Definition
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Term
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Definition
Anti-platelet drug
Inhibition of platelet ADP receptor |
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Term
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Definition
Anti-platelet drug
Inhibition of platelet ADP receptor |
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Term
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Definition
Antiplatelet drug
cAMP PDE inhibition |
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Term
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Definition
Anti-platelet drug
Blocks glycoprotein IIb/IIIa complex |
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Term
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Definition
Antiplatelet drug
Blocks glycoprotein IIb/IIIa complex |
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Term
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Definition
Anti-platelet drug
Blocks glycoprotein IIb/IIIa complex |
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Term
| How does platelet activation work? |
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Definition
- Platelet activation is iniated by ADP → ADP binds and leads to conformational change in platelet glycoprotein-IIb/IIIa → this activates the platelets and allows for binding to fibrin
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